FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963955907> ?p ?o ?g. }

• W1963955907 endingPage "2971" @default.
• W1963955907 startingPage "2966" @default.
• W1963955907 abstract "Colistin susceptibility in Pseudomonas aeruginosa is associated with a lipopolysaccharide (LPS) structure that is controlled by the modulation of several two-component regulatory systems. In this study, we attempted to elucidate the role of these two-component systems in the development of colistin resistance in P. aeruginosa. pmrA-, phoP-, parR- or cprR-inactivated mutants were constructed from a colistin-susceptible P5 strain. Colistin-resistant mutants (P5R, P5ΔpmrA-R, P5ΔphoP-R, P5ΔparR-R and P5ΔcprR-R) were developed in vitro from a wild-type strain (P5) and pmrA-, phoP-, parR- or cprR-inactivated mutants by serial passage in colistin-containing media. Expression levels of the pmrA, phoP, parR, cprR and arnB genes were determined and amino acid alterations of two-component regulatory systems during development of colistin resistance were also investigated. While P5ΔpmrA-R, P5ΔparR-R and P5ΔcprR-R showed elevated expression of the phoP gene, the expression levels of the pmrA, parR and cprR genes were not different between gene-inactivated mutants and the adapted colistin-resistant mutants. P5ΔphoP-R showed no significant elevation in expression of any of the pmrA, parR or cprR genes. The arnB gene was overexpressed in all in vitro-selected colistin-resistant mutants compared with colistin-susceptible wild-type and gene-inactivated mutants. Three amino acid alterations in PhoQ and three in ParS were identified in induced colistin-resistant mutants. Our data suggest that individual two-component systems may not be essential for the acquisition of colistin resistance in P. aeruginosa. The PhoPQ two-component system may play a major role in the development of colistin resistance in our strains, but alternative or compensatory pathways may exist." @default.
• W1963955907 created "2016-06-24" @default.
• W1963955907 creator A5009761057 @default.
• W1963955907 creator A5017145349 @default.
• W1963955907 creator A5032173154 @default.
• W1963955907 creator A5041872113 @default.
• W1963955907 creator A5077752769 @default.
• W1963955907 creator A5080891156 @default.
• W1963955907 date "2014-07-02" @default.
• W1963955907 modified "2023-10-17" @default.
• W1963955907 title "Development of colistin resistance in pmrA-, phoP-, parR- and cprR-inactivated mutants of Pseudomonas aeruginosa" @default.
• W1963955907 cites W1975920595 @default.
• W1963955907 cites W1992802365 @default.
• W1963955907 cites W2031703416 @default.
• W1963955907 cites W2058911153 @default.
• W1963955907 cites W2060967918 @default.
• W1963955907 cites W2072032949 @default.
• W1963955907 cites W2074166043 @default.
• W1963955907 cites W2075287054 @default.
• W1963955907 cites W2077668745 @default.
• W1963955907 cites W2078978136 @default.
• W1963955907 cites W2091513339 @default.
• W1963955907 cites W2103752133 @default.
• W1963955907 cites W2112028148 @default.
• W1963955907 cites W2116137883 @default.
• W1963955907 cites W2133444948 @default.
• W1963955907 cites W2137081432 @default.
• W1963955907 cites W2137799330 @default.
• W1963955907 cites W2138481512 @default.
• W1963955907 cites W2139382674 @default.
• W1963955907 cites W2152744936 @default.
• W1963955907 cites W2154713420 @default.
• W1963955907 cites W2155122915 @default.
• W1963955907 cites W2155183644 @default.
• W1963955907 cites W2160297351 @default.
• W1963955907 cites W2168485847 @default.
• W1963955907 cites W2171452890 @default.
• W1963955907 doi "https://doi.org/10.1093/jac/dku238" @default.
• W1963955907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24994873" @default.
• W1963955907 hasPublicationYear "2014" @default.
• W1963955907 type Work @default.
• W1963955907 sameAs 1963955907 @default.
• W1963955907 citedByCount "35" @default.
• W1963955907 countsByYear W19639559072014 @default.
• W1963955907 countsByYear W19639559072016 @default.
• W1963955907 countsByYear W19639559072017 @default.
• W1963955907 countsByYear W19639559072018 @default.
• W1963955907 countsByYear W19639559072019 @default.
• W1963955907 countsByYear W19639559072020 @default.
• W1963955907 countsByYear W19639559072021 @default.
• W1963955907 countsByYear W19639559072022 @default.
• W1963955907 countsByYear W19639559072023 @default.
• W1963955907 crossrefType "journal-article" @default.
• W1963955907 hasAuthorship W1963955907A5009761057 @default.
• W1963955907 hasAuthorship W1963955907A5017145349 @default.
• W1963955907 hasAuthorship W1963955907A5032173154 @default.
• W1963955907 hasAuthorship W1963955907A5041872113 @default.
• W1963955907 hasAuthorship W1963955907A5077752769 @default.
• W1963955907 hasAuthorship W1963955907A5080891156 @default.
• W1963955907 hasConcept C104317684 @default.
• W1963955907 hasConcept C138223613 @default.
• W1963955907 hasConcept C143065580 @default.
• W1963955907 hasConcept C185592680 @default.
• W1963955907 hasConcept C2777637488 @default.
• W1963955907 hasConcept C2779259085 @default.
• W1963955907 hasConcept C501593827 @default.
• W1963955907 hasConcept C523546767 @default.
• W1963955907 hasConcept C54355233 @default.
• W1963955907 hasConcept C86803240 @default.
• W1963955907 hasConcept C89423630 @default.
• W1963955907 hasConceptScore W1963955907C104317684 @default.
• W1963955907 hasConceptScore W1963955907C138223613 @default.
• W1963955907 hasConceptScore W1963955907C143065580 @default.
• W1963955907 hasConceptScore W1963955907C185592680 @default.
• W1963955907 hasConceptScore W1963955907C2777637488 @default.
• W1963955907 hasConceptScore W1963955907C2779259085 @default.
• W1963955907 hasConceptScore W1963955907C501593827 @default.
• W1963955907 hasConceptScore W1963955907C523546767 @default.
• W1963955907 hasConceptScore W1963955907C54355233 @default.
• W1963955907 hasConceptScore W1963955907C86803240 @default.
• W1963955907 hasConceptScore W1963955907C89423630 @default.
• W1963955907 hasIssue "11" @default.
• W1963955907 hasLocation W19639559071 @default.
• W1963955907 hasLocation W19639559072 @default.
• W1963955907 hasOpenAccess W1963955907 @default.
• W1963955907 hasPrimaryLocation W19639559071 @default.
• W1963955907 hasRelatedWork W1941223470 @default.
• W1963955907 hasRelatedWork W1968602861 @default.
• W1963955907 hasRelatedWork W2038305694 @default.
• W1963955907 hasRelatedWork W2123498714 @default.
• W1963955907 hasRelatedWork W2155899797 @default.
• W1963955907 hasRelatedWork W2266621686 @default.
• W1963955907 hasRelatedWork W2603651488 @default.
• W1963955907 hasRelatedWork W2993419244 @default.
• W1963955907 hasRelatedWork W4309481255 @default.
• W1963955907 hasRelatedWork W647131801 @default.
• W1963955907 hasVolume "69" @default.
• W1963955907 isParatext "false" @default.

• next