Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963957029> ?p ?o ?g. }
- W1963957029 endingPage "817" @default.
- W1963957029 startingPage "811" @default.
- W1963957029 abstract "Excitability has long been recognized as the basis for rapid signaling in the mature nervous system, but roles of channels and receptors in controlling slower processes of differentiation have been identified only more recently. Voltage-dependent and transmitter-activated channels are often expressed at early stages of development prior to synaptogenesis, and allow influx of Ca(2+). Here we examine the functions of spontaneous transient elevations of intracellular Ca(2+) in embryonic neurons. These Ca(2+) transients abruptly raise levels of Ca(2+) as much as tenfold, for brief periods, repeatedly, and can be highly localized. Like cloudbursts on the developing landscape, Ca(2+) transients modulate growth and stimulate differentiation, in a frequency-dependent manner, probably by changes in phosphorylation or proteolysis of regulatory and structural proteins in local regions. We review the mechanisms by which Ca(2+) transients are generated and their effects in regulating motility via the cytoskeleton and differentiation via transcription." @default.
- W1963957029 created "2016-06-24" @default.
- W1963957029 creator A5000132911 @default.
- W1963957029 creator A5063240894 @default.
- W1963957029 creator A5070671062 @default.
- W1963957029 creator A5085681757 @default.
- W1963957029 date "2000-08-10" @default.
- W1963957029 modified "2023-10-18" @default.
- W1963957029 title "Coding of neuronal differentiation by calcium transients" @default.
- W1963957029 cites W1508787463 @default.
- W1963957029 cites W1521357599 @default.
- W1963957029 cites W1521404049 @default.
- W1963957029 cites W1570910223 @default.
- W1963957029 cites W1572148901 @default.
- W1963957029 cites W1575107527 @default.
- W1963957029 cites W1583977712 @default.
- W1963957029 cites W1584917605 @default.
- W1963957029 cites W1613465153 @default.
- W1963957029 cites W1618814657 @default.
- W1963957029 cites W1650401181 @default.
- W1963957029 cites W1666469474 @default.
- W1963957029 cites W1831079118 @default.
- W1963957029 cites W1888933287 @default.
- W1963957029 cites W1967463041 @default.
- W1963957029 cites W1968177638 @default.
- W1963957029 cites W1975196303 @default.
- W1963957029 cites W1975564943 @default.
- W1963957029 cites W1976054166 @default.
- W1963957029 cites W1983195923 @default.
- W1963957029 cites W1984332535 @default.
- W1963957029 cites W1985493485 @default.
- W1963957029 cites W1988780886 @default.
- W1963957029 cites W1992626984 @default.
- W1963957029 cites W1994109113 @default.
- W1963957029 cites W2001382648 @default.
- W1963957029 cites W2006374456 @default.
- W1963957029 cites W2006411840 @default.
- W1963957029 cites W2006850125 @default.
- W1963957029 cites W2010613687 @default.
- W1963957029 cites W2011799194 @default.
- W1963957029 cites W2020634566 @default.
- W1963957029 cites W2022200790 @default.
- W1963957029 cites W2027416474 @default.
- W1963957029 cites W2038781848 @default.
- W1963957029 cites W2048410846 @default.
- W1963957029 cites W2054196099 @default.
- W1963957029 cites W2054971033 @default.
- W1963957029 cites W2059545632 @default.
- W1963957029 cites W2061207726 @default.
- W1963957029 cites W2061603242 @default.
- W1963957029 cites W2065217821 @default.
- W1963957029 cites W2066014797 @default.
- W1963957029 cites W2068016566 @default.
- W1963957029 cites W2069306062 @default.
- W1963957029 cites W2071140879 @default.
- W1963957029 cites W2074683128 @default.
- W1963957029 cites W2075183875 @default.
- W1963957029 cites W2080414326 @default.
- W1963957029 cites W2081669905 @default.
- W1963957029 cites W2081876680 @default.
- W1963957029 cites W2083579647 @default.
- W1963957029 cites W2085287004 @default.
- W1963957029 cites W2086489883 @default.
- W1963957029 cites W2094182857 @default.
- W1963957029 cites W2098257766 @default.
- W1963957029 cites W2098553579 @default.
- W1963957029 cites W2099759578 @default.
- W1963957029 cites W2100682882 @default.
- W1963957029 cites W2101116356 @default.
- W1963957029 cites W2115245987 @default.
- W1963957029 cites W2119405032 @default.
- W1963957029 cites W2124248841 @default.
- W1963957029 cites W2125269304 @default.
- W1963957029 cites W2130407647 @default.
- W1963957029 cites W2130413520 @default.
- W1963957029 cites W2131654433 @default.
- W1963957029 cites W2133742018 @default.
- W1963957029 cites W2135011583 @default.
- W1963957029 cites W2141895876 @default.
- W1963957029 cites W2150749692 @default.
- W1963957029 cites W2153039896 @default.
- W1963957029 cites W2155883881 @default.
- W1963957029 cites W2157032417 @default.
- W1963957029 cites W2157827370 @default.
- W1963957029 cites W2169480040 @default.
- W1963957029 cites W2324743087 @default.
- W1963957029 doi "https://doi.org/10.1002/1521-1878(200009)22:9<811::aid-bies6>3.0.co;2-g" @default.
- W1963957029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10944583" @default.
- W1963957029 hasPublicationYear "2000" @default.
- W1963957029 type Work @default.
- W1963957029 sameAs 1963957029 @default.
- W1963957029 citedByCount "141" @default.
- W1963957029 countsByYear W19639570292012 @default.
- W1963957029 countsByYear W19639570292013 @default.
- W1963957029 countsByYear W19639570292014 @default.
- W1963957029 countsByYear W19639570292015 @default.
- W1963957029 countsByYear W19639570292016 @default.
- W1963957029 countsByYear W19639570292017 @default.