Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963958310> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W1963958310 endingPage "31" @default.
- W1963958310 startingPage "27" @default.
- W1963958310 abstract "Published results of dose-response effects of adrenergic drugs (epinephrine [E]) vary so much between studies because of differences in animal models and duration of ischemia before drug administration. In this investigation the effects of different doses of E on coronary perfusion pressure (CPP), left ventricular myocardial blood flow (MBF) and resuscitation success were compared during closed-chest cardiopulmonary rest scitation (CRP) after a 4-minute period of ventricular fibrillation in 28 pigs. MBF was measured during normal sinus rhythm using tracer microspheres. After 4 minutes of ventricular fibrillation CPR was performed with the use of a pneumatic piston compressor. After 4 minutes of mechanical measures only, the animals were randomly allocated into four groups of seven, receiving 0.015, 0.030, 0.045, and 0.090 mg/kg E intravenously respectively. MBF measurements were started 45 seconds after E administration; hemodynamic measurements after 90 seconds. Four minutes after the first administration, the same E dose was given before defibrillation. The CPP of animals given 0.015, 0.030, 0.045 and 0.090 mg/kg E were as follows: 16.3 ± 6.1, 25.6 ± 5.8, 33.2 ± 8.4 and 30.4 ± 6.3 mm Hg. The left ventricular MBF values were: 14 ± 9, 27 ± 11, 43 ± 6, 46 ± 10 mL/min/100 g. The differences between the groups receiving 0.015 and 0.045 mg/kg and between the groups receiving 0.015 mg/kg and 0.090 mg/kg were statistically significant (P < .05). Resuscitation success was 14.3%, 42.9%, 100% and 86.7% respectively. A significant difference in resuscitation success was found only betwen 0.015 mg/kg and 0.045 mg/kg E. Our results suggest that after a 4-minute period of arrest and 4 minutes of CPR, CPP, MBF and resuscitation success are increased when E is given at a dosage of up to 0.045 mg/kg; however, the increase to 0.090 mg/kg does not lead to any further improvement." @default.
- W1963958310 created "2016-06-24" @default.
- W1963958310 creator A5008632966 @default.
- W1963958310 creator A5037979790 @default.
- W1963958310 creator A5065296321 @default.
- W1963958310 date "1991-01-01" @default.
- W1963958310 modified "2023-10-03" @default.
- W1963958310 title "Comparison of different doses of epinephrine on myocardial perfusion and resuscitation success during cardiopulmonary resuscitation in a pig model" @default.
- W1963958310 cites W1982308947 @default.
- W1963958310 cites W1988676192 @default.
- W1963958310 cites W1992956762 @default.
- W1963958310 cites W2000460503 @default.
- W1963958310 cites W2011319443 @default.
- W1963958310 cites W2026498685 @default.
- W1963958310 cites W2044924835 @default.
- W1963958310 cites W2050222804 @default.
- W1963958310 cites W2075658212 @default.
- W1963958310 cites W2122689055 @default.
- W1963958310 cites W4247099995 @default.
- W1963958310 doi "https://doi.org/10.1016/0735-6757(91)90008-8" @default.
- W1963958310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1898700" @default.
- W1963958310 hasPublicationYear "1991" @default.
- W1963958310 type Work @default.
- W1963958310 sameAs 1963958310 @default.
- W1963958310 citedByCount "110" @default.
- W1963958310 countsByYear W19639583102012 @default.
- W1963958310 countsByYear W19639583102013 @default.
- W1963958310 countsByYear W19639583102014 @default.
- W1963958310 countsByYear W19639583102015 @default.
- W1963958310 countsByYear W19639583102018 @default.
- W1963958310 countsByYear W19639583102019 @default.
- W1963958310 countsByYear W19639583102021 @default.
- W1963958310 countsByYear W19639583102023 @default.
- W1963958310 crossrefType "journal-article" @default.
- W1963958310 hasAuthorship W1963958310A5008632966 @default.
- W1963958310 hasAuthorship W1963958310A5037979790 @default.
- W1963958310 hasAuthorship W1963958310A5065296321 @default.
- W1963958310 hasConcept C126322002 @default.
- W1963958310 hasConcept C146957229 @default.
- W1963958310 hasConcept C158846371 @default.
- W1963958310 hasConcept C164705383 @default.
- W1963958310 hasConcept C178853913 @default.
- W1963958310 hasConcept C2775859304 @default.
- W1963958310 hasConcept C2775914520 @default.
- W1963958310 hasConcept C2777055891 @default.
- W1963958310 hasConcept C2777795826 @default.
- W1963958310 hasConcept C2777862461 @default.
- W1963958310 hasConcept C2778165595 @default.
- W1963958310 hasConcept C2779161974 @default.
- W1963958310 hasConcept C2781005686 @default.
- W1963958310 hasConcept C42219234 @default.
- W1963958310 hasConcept C71924100 @default.
- W1963958310 hasConceptScore W1963958310C126322002 @default.
- W1963958310 hasConceptScore W1963958310C146957229 @default.
- W1963958310 hasConceptScore W1963958310C158846371 @default.
- W1963958310 hasConceptScore W1963958310C164705383 @default.
- W1963958310 hasConceptScore W1963958310C178853913 @default.
- W1963958310 hasConceptScore W1963958310C2775859304 @default.
- W1963958310 hasConceptScore W1963958310C2775914520 @default.
- W1963958310 hasConceptScore W1963958310C2777055891 @default.
- W1963958310 hasConceptScore W1963958310C2777795826 @default.
- W1963958310 hasConceptScore W1963958310C2777862461 @default.
- W1963958310 hasConceptScore W1963958310C2778165595 @default.
- W1963958310 hasConceptScore W1963958310C2779161974 @default.
- W1963958310 hasConceptScore W1963958310C2781005686 @default.
- W1963958310 hasConceptScore W1963958310C42219234 @default.
- W1963958310 hasConceptScore W1963958310C71924100 @default.
- W1963958310 hasIssue "1" @default.
- W1963958310 hasLocation W19639583101 @default.
- W1963958310 hasLocation W19639583102 @default.
- W1963958310 hasOpenAccess W1963958310 @default.
- W1963958310 hasPrimaryLocation W19639583101 @default.
- W1963958310 hasRelatedWork W1967077281 @default.
- W1963958310 hasRelatedWork W2008326546 @default.
- W1963958310 hasRelatedWork W2014364037 @default.
- W1963958310 hasRelatedWork W2026216854 @default.
- W1963958310 hasRelatedWork W2070857469 @default.
- W1963958310 hasRelatedWork W2080889319 @default.
- W1963958310 hasRelatedWork W2095374423 @default.
- W1963958310 hasRelatedWork W2098746076 @default.
- W1963958310 hasRelatedWork W2794208217 @default.
- W1963958310 hasRelatedWork W3024439425 @default.
- W1963958310 hasVolume "9" @default.
- W1963958310 isParatext "false" @default.
- W1963958310 isRetracted "false" @default.
- W1963958310 magId "1963958310" @default.
- W1963958310 workType "article" @default.