FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963963422> ?p ?o ?g. }

• W1963963422 endingPage "531" @default.
• W1963963422 startingPage "527" @default.
• W1963963422 abstract "The influence of the polymorphisms of the CX3CR1 chemokine receptor gene on the natural history of HIV-1 infection is controversial. This study aimed to determine whether functionally active CX3CR1 genetic variants are associated with long-term nonprogressive infection of >15 years in HIV-1-infected Spanish patients.Two single-nucleotide polymorphisms, V249I (G > A) and T280M (C > T), of the CX3CR1 gene were assessed in 271 Spaniards. These included 60 HIV-1-infected patients who were long-term nonprogressors (LTNPs) of >15 years, 109 HIV-1-infected patients who were usual progressors (UPs), and 102 control subjects. The CCR5Delta32 was also assessed. Genotyping was performed using polymerase chain reaction and automatic sequencing analysis methods on white cell DNA. Genotype and allele frequencies were compared by the chi test and the Fisher exact test.The frequencies of the 249I variant allele were 42% for LTNPs, 24.5% for UPs, and 35% for healthy controls; the differences between LTNPs and UPs were significant (odds ratio 0.46; 95% CI: 0.27 to 0.75; P = 0.0017). For 280M the distribution was 16% for LTNPs, 14% for UPs, and 17% for healthy controls (P = NS). The haplotype 249I280T was significantly more common in LTNPs than in UPs (P = 0.0007). These results persisted after excluding from the analysis the individuals carrying the CCR5Delta32.CX3CR1 249I variant allele is more frequent in Spanish HIV-1-infected LTNPs of >15 years. This effect is independent of the presence of the CCR5Delta32 allele." @default.
• W1963963422 created "2016-06-24" @default.
• W1963963422 creator A5000687698 @default.
• W1963963422 creator A5023915997 @default.
• W1963963422 creator A5025415635 @default.
• W1963963422 creator A5032925281 @default.
• W1963963422 creator A5035886371 @default.
• W1963963422 creator A5038068652 @default.
• W1963963422 creator A5050995269 @default.
• W1963963422 creator A5055528997 @default.
• W1963963422 creator A5060181762 @default.
• W1963963422 creator A5065394245 @default.
• W1963963422 creator A5070165631 @default.
• W1963963422 creator A5072944678 @default.
• W1963963422 creator A5074510707 @default.
• W1963963422 creator A5080750776 @default.
• W1963963422 creator A5081965144 @default.
• W1963963422 creator A5083719374 @default.
• W1963963422 date "2005-12-15" @default.
• W1963963422 modified "2023-10-18" @default.
• W1963963422 title "Spanish HIV-1-Infected Long-Term Nonprogressors of More Than 15 Years Have an Increased Frequency of the CX3CR1 249I Variant Allele" @default.
• W1963963422 cites W1983988906 @default.
• W1963963422 cites W2011747787 @default.
• W1963963422 cites W2023878269 @default.
• W1963963422 cites W2031660981 @default.
• W1963963422 cites W2036652038 @default.
• W1963963422 cites W2052615997 @default.
• W1963963422 cites W2056993385 @default.
• W1963963422 cites W2075783643 @default.
• W1963963422 cites W2101487960 @default.
• W1963963422 cites W2113263264 @default.
• W1963963422 cites W2142307660 @default.
• W1963963422 cites W2145856615 @default.
• W1963963422 cites W2152453984 @default.
• W1963963422 cites W2157355643 @default.
• W1963963422 cites W2312650761 @default.
• W1963963422 doi "https://doi.org/10.1097/01.qai.0000186362.50457.e0" @default.
• W1963963422 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16284527" @default.
• W1963963422 hasPublicationYear "2005" @default.
• W1963963422 type Work @default.
• W1963963422 sameAs 1963963422 @default.
• W1963963422 citedByCount "31" @default.
• W1963963422 countsByYear W19639634222012 @default.
• W1963963422 countsByYear W19639634222013 @default.
• W1963963422 countsByYear W19639634222014 @default.
• W1963963422 countsByYear W19639634222016 @default.
• W1963963422 countsByYear W19639634222017 @default.
• W1963963422 countsByYear W19639634222020 @default.
• W1963963422 countsByYear W19639634222022 @default.
• W1963963422 crossrefType "journal-article" @default.
• W1963963422 hasAuthorship W1963963422A5000687698 @default.
• W1963963422 hasAuthorship W1963963422A5023915997 @default.
• W1963963422 hasAuthorship W1963963422A5025415635 @default.
• W1963963422 hasAuthorship W1963963422A5032925281 @default.
• W1963963422 hasAuthorship W1963963422A5035886371 @default.
• W1963963422 hasAuthorship W1963963422A5038068652 @default.
• W1963963422 hasAuthorship W1963963422A5050995269 @default.
• W1963963422 hasAuthorship W1963963422A5055528997 @default.
• W1963963422 hasAuthorship W1963963422A5060181762 @default.
• W1963963422 hasAuthorship W1963963422A5065394245 @default.
• W1963963422 hasAuthorship W1963963422A5070165631 @default.
• W1963963422 hasAuthorship W1963963422A5072944678 @default.
• W1963963422 hasAuthorship W1963963422A5074510707 @default.
• W1963963422 hasAuthorship W1963963422A5080750776 @default.
• W1963963422 hasAuthorship W1963963422A5081965144 @default.
• W1963963422 hasAuthorship W1963963422A5083719374 @default.
• W1963963422 hasBestOaLocation W19639634221 @default.
• W1963963422 hasConcept C104317684 @default.
• W1963963422 hasConcept C126322002 @default.
• W1963963422 hasConcept C12823836 @default.
• W1963963422 hasConcept C13373296 @default.
• W1963963422 hasConcept C135763542 @default.
• W1963963422 hasConcept C153209595 @default.
• W1963963422 hasConcept C156957248 @default.
• W1963963422 hasConcept C157410074 @default.
• W1963963422 hasConcept C159047783 @default.
• W1963963422 hasConcept C180754005 @default.
• W1963963422 hasConcept C191093355 @default.
• W1963963422 hasConcept C197754878 @default.
• W1963963422 hasConcept C203014093 @default.
• W1963963422 hasConcept C2776914184 @default.
• W1963963422 hasConcept C31179232 @default.
• W1963963422 hasConcept C31467283 @default.
• W1963963422 hasConcept C37463918 @default.
• W1963963422 hasConcept C54355233 @default.
• W1963963422 hasConcept C71924100 @default.
• W1963963422 hasConcept C86803240 @default.
• W1963963422 hasConceptScore W1963963422C104317684 @default.
• W1963963422 hasConceptScore W1963963422C126322002 @default.
• W1963963422 hasConceptScore W1963963422C12823836 @default.
• W1963963422 hasConceptScore W1963963422C13373296 @default.
• W1963963422 hasConceptScore W1963963422C135763542 @default.
• W1963963422 hasConceptScore W1963963422C153209595 @default.
• W1963963422 hasConceptScore W1963963422C156957248 @default.
• W1963963422 hasConceptScore W1963963422C157410074 @default.
• W1963963422 hasConceptScore W1963963422C159047783 @default.
• W1963963422 hasConceptScore W1963963422C180754005 @default.
• W1963963422 hasConceptScore W1963963422C191093355 @default.

• next