Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963965210> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1963965210 endingPage "157" @default.
- W1963965210 startingPage "152" @default.
- W1963965210 abstract "Twenty-two patients with acute myeloid leukaemia were recruited into a phase I/II clinical trial investigating the vaccination of patients in complete remission (CR) with autologous dendritic-like leukaemia cells (DLLC). At trial entry, leukaemia cells were harvested and tested for their ability to undergo cytokine-induced dendritic cell differentiation. Patients were then treated with intensive chemotherapy. Five patients achieved both CR and had leukaemia cells that successfully underwent differentiation and therefore proceeded to vaccination. Four escalating doses of DLLC were administered weekly by subcutaneous injection. Vaccination was generally well tolerated although one patient developed extensive eczema and an increased antinuclear factor titre possibly indicating induction of autoimmunity. Development of anti-leukaemic T-cell responses was assessed by enzyme-linked immunospot analysis of gamma-interferon secreting T lymphocytes and by human leucocyte antigen tetramer analysis for WT1-specific T cells. Increases in anti-leukaemic T-cell responses were demonstrated in four patients, but only two of the five remained in remission more than 12 months postvaccination. The study has demonstrated that generation of DLLC is feasible in only a subgroup of patients and is currently neither broadly applicable or clinically effective." @default.
- W1963965210 created "2016-06-24" @default.
- W1963965210 creator A5031926559 @default.
- W1963965210 creator A5061546890 @default.
- W1963965210 creator A5067123999 @default.
- W1963965210 creator A5068980036 @default.
- W1963965210 creator A5069811614 @default.
- W1963965210 creator A5070032224 @default.
- W1963965210 creator A5073677845 @default.
- W1963965210 creator A5075942749 @default.
- W1963965210 creator A5077413902 @default.
- W1963965210 creator A5087077867 @default.
- W1963965210 creator A5087195871 @default.
- W1963965210 date "2006-02-10" @default.
- W1963965210 modified "2023-10-17" @default.
- W1963965210 title "Phase I/II study of vaccination with dendritic-like leukaemia cells for the immunotherapy of acute myeloid leukaemia" @default.
- W1963965210 cites W1143126211 @default.
- W1963965210 cites W159030646 @default.
- W1963965210 cites W1769456965 @default.
- W1963965210 cites W1968854172 @default.
- W1963965210 cites W2011614805 @default.
- W1963965210 cites W2039239970 @default.
- W1963965210 cites W2052997401 @default.
- W1963965210 cites W2075810280 @default.
- W1963965210 cites W2080527933 @default.
- W1963965210 cites W2090263060 @default.
- W1963965210 cites W2136826571 @default.
- W1963965210 cites W2246326369 @default.
- W1963965210 cites W39579847 @default.
- W1963965210 doi "https://doi.org/10.1111/j.1365-2141.2006.05997.x" @default.
- W1963965210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16611305" @default.
- W1963965210 hasPublicationYear "2006" @default.
- W1963965210 type Work @default.
- W1963965210 sameAs 1963965210 @default.
- W1963965210 citedByCount "79" @default.
- W1963965210 countsByYear W19639652102012 @default.
- W1963965210 countsByYear W19639652102013 @default.
- W1963965210 countsByYear W19639652102014 @default.
- W1963965210 countsByYear W19639652102015 @default.
- W1963965210 countsByYear W19639652102016 @default.
- W1963965210 countsByYear W19639652102017 @default.
- W1963965210 countsByYear W19639652102018 @default.
- W1963965210 countsByYear W19639652102019 @default.
- W1963965210 countsByYear W19639652102020 @default.
- W1963965210 countsByYear W19639652102021 @default.
- W1963965210 countsByYear W19639652102022 @default.
- W1963965210 countsByYear W19639652102023 @default.
- W1963965210 crossrefType "journal-article" @default.
- W1963965210 hasAuthorship W1963965210A5031926559 @default.
- W1963965210 hasAuthorship W1963965210A5061546890 @default.
- W1963965210 hasAuthorship W1963965210A5067123999 @default.
- W1963965210 hasAuthorship W1963965210A5068980036 @default.
- W1963965210 hasAuthorship W1963965210A5069811614 @default.
- W1963965210 hasAuthorship W1963965210A5070032224 @default.
- W1963965210 hasAuthorship W1963965210A5073677845 @default.
- W1963965210 hasAuthorship W1963965210A5075942749 @default.
- W1963965210 hasAuthorship W1963965210A5077413902 @default.
- W1963965210 hasAuthorship W1963965210A5087077867 @default.
- W1963965210 hasAuthorship W1963965210A5087195871 @default.
- W1963965210 hasBestOaLocation W19639652101 @default.
- W1963965210 hasConcept C147483822 @default.
- W1963965210 hasConcept C203014093 @default.
- W1963965210 hasConcept C22070199 @default.
- W1963965210 hasConcept C2777701055 @default.
- W1963965210 hasConcept C2778170410 @default.
- W1963965210 hasConcept C2779282312 @default.
- W1963965210 hasConcept C2993296363 @default.
- W1963965210 hasConcept C71924100 @default.
- W1963965210 hasConcept C8891405 @default.
- W1963965210 hasConceptScore W1963965210C147483822 @default.
- W1963965210 hasConceptScore W1963965210C203014093 @default.
- W1963965210 hasConceptScore W1963965210C22070199 @default.
- W1963965210 hasConceptScore W1963965210C2777701055 @default.
- W1963965210 hasConceptScore W1963965210C2778170410 @default.
- W1963965210 hasConceptScore W1963965210C2779282312 @default.
- W1963965210 hasConceptScore W1963965210C2993296363 @default.
- W1963965210 hasConceptScore W1963965210C71924100 @default.
- W1963965210 hasConceptScore W1963965210C8891405 @default.
- W1963965210 hasIssue "2" @default.
- W1963965210 hasLocation W19639652101 @default.
- W1963965210 hasLocation W19639652102 @default.
- W1963965210 hasOpenAccess W1963965210 @default.
- W1963965210 hasPrimaryLocation W19639652101 @default.
- W1963965210 hasRelatedWork W110876028 @default.
- W1963965210 hasRelatedWork W137690307 @default.
- W1963965210 hasRelatedWork W2004182571 @default.
- W1963965210 hasRelatedWork W2023907037 @default.
- W1963965210 hasRelatedWork W2073671804 @default.
- W1963965210 hasRelatedWork W2136925073 @default.
- W1963965210 hasRelatedWork W2372050649 @default.
- W1963965210 hasRelatedWork W2800200469 @default.
- W1963965210 hasRelatedWork W2407467520 @default.
- W1963965210 hasRelatedWork W2575030026 @default.
- W1963965210 hasVolume "133" @default.
- W1963965210 isParatext "false" @default.
- W1963965210 isRetracted "false" @default.
- W1963965210 magId "1963965210" @default.
- W1963965210 workType "article" @default.