Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963965930> ?p ?o ?g. }
- W1963965930 endingPage "228" @default.
- W1963965930 startingPage "219" @default.
- W1963965930 abstract "Nineteen biotinylated squamocin/bullatacin derivatives have been synthesized for targeted delivery to biotin receptor overexpressed tumor cells. Most biotinylated squamocin and bullatacin derivatives show similar in vitro cytotoxicity against the biotin receptor non-overexpressed L1210 cells as squamocin and bullatacin, respectively, while against biotin receptor overexpressed 4T1 and P815 tumor cells, several derivatives show significantly higher potency and better selectivity. Among all the synthesized compounds, 15,28-di-O-(6-biotinylamidohexanoyl)squamocin (16) is the most potent, which is 10 and 26 times more active than squamocin against 4T1 and P815 cells, respectively. Compound 16 also appears to be six and fifteen times more selective than squamocin towards 4T1 and P815 cells, respectively, against L1210 cells. The structure activity relationship analysis has revealed that the preferred site for biotinylation is different for squamocin and bullatacin, and it also depends on whether a linking spacer is present." @default.
- W1963965930 created "2016-06-24" @default.
- W1963965930 creator A5006260687 @default.
- W1963965930 creator A5045535171 @default.
- W1963965930 creator A5051260759 @default.
- W1963965930 creator A5056946862 @default.
- W1963965930 date "2014-01-01" @default.
- W1963965930 modified "2023-10-07" @default.
- W1963965930 title "Synthesis and tumor cell growth inhibitory activity of biotinylated annonaceous acetogenins" @default.
- W1963965930 cites W119277614 @default.
- W1963965930 cites W126273248 @default.
- W1963965930 cites W1938548874 @default.
- W1963965930 cites W1967393143 @default.
- W1963965930 cites W1970377073 @default.
- W1963965930 cites W1973008499 @default.
- W1963965930 cites W1978925562 @default.
- W1963965930 cites W1986446988 @default.
- W1963965930 cites W1987898644 @default.
- W1963965930 cites W1988754095 @default.
- W1963965930 cites W1999528670 @default.
- W1963965930 cites W1999849750 @default.
- W1963965930 cites W2005572726 @default.
- W1963965930 cites W2020618574 @default.
- W1963965930 cites W2021679469 @default.
- W1963965930 cites W2022150020 @default.
- W1963965930 cites W2023376720 @default.
- W1963965930 cites W2034991073 @default.
- W1963965930 cites W2037991871 @default.
- W1963965930 cites W2046052775 @default.
- W1963965930 cites W2049344058 @default.
- W1963965930 cites W2049962625 @default.
- W1963965930 cites W2050146398 @default.
- W1963965930 cites W2059750619 @default.
- W1963965930 cites W2061460215 @default.
- W1963965930 cites W2062851123 @default.
- W1963965930 cites W2063315679 @default.
- W1963965930 cites W2064834559 @default.
- W1963965930 cites W2076637948 @default.
- W1963965930 cites W2083306481 @default.
- W1963965930 cites W2085470629 @default.
- W1963965930 cites W2105633165 @default.
- W1963965930 cites W2112442437 @default.
- W1963965930 cites W2118083879 @default.
- W1963965930 cites W2120230603 @default.
- W1963965930 cites W2120766304 @default.
- W1963965930 cites W2132872213 @default.
- W1963965930 cites W2142576295 @default.
- W1963965930 cites W2154278867 @default.
- W1963965930 cites W2172164746 @default.
- W1963965930 cites W2331440032 @default.
- W1963965930 cites W4255645423 @default.
- W1963965930 cites W4376849577 @default.
- W1963965930 doi "https://doi.org/10.1016/j.ejmech.2013.11.012" @default.
- W1963965930 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24308999" @default.
- W1963965930 hasPublicationYear "2014" @default.
- W1963965930 type Work @default.
- W1963965930 sameAs 1963965930 @default.
- W1963965930 citedByCount "70" @default.
- W1963965930 countsByYear W19639659302014 @default.
- W1963965930 countsByYear W19639659302015 @default.
- W1963965930 countsByYear W19639659302016 @default.
- W1963965930 countsByYear W19639659302017 @default.
- W1963965930 countsByYear W19639659302018 @default.
- W1963965930 countsByYear W19639659302019 @default.
- W1963965930 countsByYear W19639659302020 @default.
- W1963965930 countsByYear W19639659302021 @default.
- W1963965930 countsByYear W19639659302022 @default.
- W1963965930 countsByYear W19639659302023 @default.
- W1963965930 crossrefType "journal-article" @default.
- W1963965930 hasAuthorship W1963965930A5006260687 @default.
- W1963965930 hasAuthorship W1963965930A5045535171 @default.
- W1963965930 hasAuthorship W1963965930A5051260759 @default.
- W1963965930 hasAuthorship W1963965930A5056946862 @default.
- W1963965930 hasConcept C109316439 @default.
- W1963965930 hasConcept C170493617 @default.
- W1963965930 hasConcept C185592680 @default.
- W1963965930 hasConcept C202751555 @default.
- W1963965930 hasConcept C204628709 @default.
- W1963965930 hasConcept C2778204606 @default.
- W1963965930 hasConcept C54355233 @default.
- W1963965930 hasConcept C55493867 @default.
- W1963965930 hasConcept C62112901 @default.
- W1963965930 hasConcept C81885089 @default.
- W1963965930 hasConcept C86803240 @default.
- W1963965930 hasConceptScore W1963965930C109316439 @default.
- W1963965930 hasConceptScore W1963965930C170493617 @default.
- W1963965930 hasConceptScore W1963965930C185592680 @default.
- W1963965930 hasConceptScore W1963965930C202751555 @default.
- W1963965930 hasConceptScore W1963965930C204628709 @default.
- W1963965930 hasConceptScore W1963965930C2778204606 @default.
- W1963965930 hasConceptScore W1963965930C54355233 @default.
- W1963965930 hasConceptScore W1963965930C55493867 @default.
- W1963965930 hasConceptScore W1963965930C62112901 @default.
- W1963965930 hasConceptScore W1963965930C81885089 @default.
- W1963965930 hasConceptScore W1963965930C86803240 @default.
- W1963965930 hasLocation W19639659301 @default.
- W1963965930 hasLocation W19639659302 @default.
- W1963965930 hasOpenAccess W1963965930 @default.