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• W1963966175 abstract "The sphingoid bases of sphingolipids, including ceramides, can vary in length from 12 to >20 carbons. To study how such length variation affects the bilayer properties of ceramides, we synthesized ceramides consisting of a C12-, C14-, C16-, C18-, or C20-sphing-4-enin derivative coupled to palmitic acid. The ceramides were studied in mixtures with palmitoyloleoylphosphocholine (POPC) and/or palmitoylsphingomyelin (PSM), and in more complex bilayers also containing cholesterol. The trans-parinaric acid lifetimes showed that 12:1- and 14:1-PCer failed to increase the order of POPC bilayers, whereas 16:1-, 18:1-, and 20:1-PCer induced ordered- or gel-phase formation. Nevertheless, all of the analogs were able to thermally stabilize PSM, and a chain-length-dependent increase in the main phase transition temperature of equimolar PSM/Cer bilayers was revealed by differential scanning calorimetry. Similar thermal stabilization of PSM-rich domains by the ceramides was observed in POPC bilayers with a trans-parinaric acid-quenching assay. A cholestatrienol-quenching assay and sterol partitioning experiments showed that 18:1- and 20:1-PCer formed sterol-excluding gel phases with PSM, reducing the overall bilayer affinity of sterol. The effect of 16:1-PCer on sterol distribution was less dramatic, and no displacement of sterol from the PSM environment was observed with 12:1- and 14:1-PCer. The results are discussed in relation to other structural features that affect the bilayer properties of ceramides." @default.
• W1963966175 created "2016-06-24" @default.
• W1963966175 creator A5020977014 @default.
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• W1963966175 creator A5049433314 @default.
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• W1963966175 date "2012-11-01" @default.
• W1963966175 modified "2023-10-13" @default.
• W1963966175 title "Importance of the Sphingoid Base Length for the Membrane Properties of Ceramides" @default.
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• W1963966175 doi "https://doi.org/10.1016/j.bpj.2012.09.018" @default.
• W1963966175 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3491676" @default.
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