FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963967314> ?p ?o ?g. }

• W1963967314 endingPage "621" @default.
• W1963967314 startingPage "608" @default.
• W1963967314 abstract "Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disorder of unknown etiology. Several studies have demonstrated an association between pulmonary infection with a herpesvirus and IPF. Based on those observations, we have developed a mouse model in which interferon (IFN)gammaR(-/-) mice infected intranasally with murine gammaherpesvirus 68 (MHV68) develop lung fibrosis. We hypothesize that viral load was a critical factor for the development of fibrosis. Because nuclear factor (NF)-kappaB signaling is required to efficiently establish gammaherpesvirus, latency we infected IFNgammaR(-/-) mice with a MHV68 virus that expresses a mutant dominant inhibitor of the NF-kappaB signaling pathway, called IkappaBalphaM. Striking differences were observed at the onset of the chronic infection, which correlated with a decreased virus load in mice infected with MHV68-IkappaBalphaM compared with mice infected with control MHV68 (MHV68-MR). IFNgammaR(-/-) mice infected with MHV68-IkappaBalphaM lacked vasculitis and fibrosis 15 to 120 days post infection. Inhibition of NF-kappaB in MHV68-infected cells of the lungs diminished the expression of the fibrocyte recruiting chemokines monocyte chemoattractant protein 1 (MCP-1) and CXCL12, ameliorated macrophage expression of markers of alternative activation, and failed to increase expression of the integrin alphavbeta6, which is implicated in the activation of the profibrotic factor TGF-beta. Thus, the inhibition of NF-kappaB signaling in the infected lung cells of IFNgammaR(-/-) mice reduces virus persistence and ameliorates profibrotic events. Host determinants of latency might therefore represent new therapeutic targets for gammaherpesvirus-associated pulmonary fibrosis." @default.
• W1963967314 created "2016-06-24" @default.
• W1963967314 creator A5009748553 @default.
• W1963967314 creator A5012860467 @default.
• W1963967314 creator A5016561426 @default.
• W1963967314 creator A5042527382 @default.
• W1963967314 creator A5073595309 @default.
• W1963967314 creator A5079599264 @default.
• W1963967314 creator A5087409511 @default.
• W1963967314 creator A5089333648 @default.
• W1963967314 date "2010-08-01" @default.
• W1963967314 modified "2023-10-18" @default.
• W1963967314 title "Inhibition of NF-κB Signaling Reduces Virus Load and Gammaherpesvirus-Induced Pulmonary Fibrosis" @default.
• W1963967314 cites W1480466711 @default.
• W1963967314 cites W1607710706 @default.
• W1963967314 cites W1915074145 @default.
• W1963967314 cites W1968353658 @default.
• W1963967314 cites W1972494520 @default.
• W1963967314 cites W1986736465 @default.
• W1963967314 cites W1994836525 @default.
• W1963967314 cites W1998975199 @default.
• W1963967314 cites W2005707246 @default.
• W1963967314 cites W2011093270 @default.
• W1963967314 cites W2012393190 @default.
• W1963967314 cites W2025514405 @default.
• W1963967314 cites W2028758423 @default.
• W1963967314 cites W2030198326 @default.
• W1963967314 cites W2031375858 @default.
• W1963967314 cites W2038482344 @default.
• W1963967314 cites W2043096533 @default.
• W1963967314 cites W2046750432 @default.
• W1963967314 cites W2048016554 @default.
• W1963967314 cites W2048353858 @default.
• W1963967314 cites W2053739288 @default.
• W1963967314 cites W2054891396 @default.
• W1963967314 cites W2063215141 @default.
• W1963967314 cites W2069109190 @default.
• W1963967314 cites W2071710899 @default.
• W1963967314 cites W2073517332 @default.
• W1963967314 cites W2074372927 @default.
• W1963967314 cites W2081051180 @default.
• W1963967314 cites W2081920416 @default.
• W1963967314 cites W2091695331 @default.
• W1963967314 cites W2093907019 @default.
• W1963967314 cites W2098763351 @default.
• W1963967314 cites W2104778949 @default.
• W1963967314 cites W2108233169 @default.
• W1963967314 cites W2109527049 @default.
• W1963967314 cites W2109803801 @default.
• W1963967314 cites W2111368862 @default.
• W1963967314 cites W2111656409 @default.
• W1963967314 cites W2114063557 @default.
• W1963967314 cites W2115435697 @default.
• W1963967314 cites W2119246911 @default.
• W1963967314 cites W2121154940 @default.
• W1963967314 cites W2128181554 @default.
• W1963967314 cites W2133284260 @default.
• W1963967314 cites W2143883175 @default.
• W1963967314 cites W2146375964 @default.
• W1963967314 cites W2147763208 @default.
• W1963967314 cites W2148556482 @default.
• W1963967314 cites W2150185396 @default.
• W1963967314 cites W2155287377 @default.
• W1963967314 cites W2159035239 @default.
• W1963967314 cites W2159522076 @default.
• W1963967314 cites W2160515346 @default.
• W1963967314 cites W2162514162 @default.
• W1963967314 cites W2166781237 @default.
• W1963967314 cites W2170879194 @default.
• W1963967314 cites W2171232463 @default.
• W1963967314 cites W2626588662 @default.
• W1963967314 cites W4252082388 @default.
• W1963967314 cites W2038890616 @default.
• W1963967314 doi "https://doi.org/10.2353/ajpath.2010.091122" @default.
• W1963967314 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2913377" @default.
• W1963967314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20566741" @default.
• W1963967314 hasPublicationYear "2010" @default.
• W1963967314 type Work @default.
• W1963967314 sameAs 1963967314 @default.
• W1963967314 citedByCount "29" @default.
• W1963967314 countsByYear W19639673142012 @default.
• W1963967314 countsByYear W19639673142013 @default.
• W1963967314 countsByYear W19639673142014 @default.
• W1963967314 countsByYear W19639673142015 @default.
• W1963967314 countsByYear W19639673142016 @default.
• W1963967314 countsByYear W19639673142017 @default.
• W1963967314 countsByYear W19639673142018 @default.
• W1963967314 countsByYear W19639673142019 @default.
• W1963967314 countsByYear W19639673142020 @default.
• W1963967314 countsByYear W19639673142021 @default.
• W1963967314 countsByYear W19639673142022 @default.
• W1963967314 crossrefType "journal-article" @default.
• W1963967314 hasAuthorship W1963967314A5009748553 @default.
• W1963967314 hasAuthorship W1963967314A5012860467 @default.
• W1963967314 hasAuthorship W1963967314A5016561426 @default.
• W1963967314 hasAuthorship W1963967314A5042527382 @default.
• W1963967314 hasAuthorship W1963967314A5073595309 @default.
• W1963967314 hasAuthorship W1963967314A5079599264 @default.

• next