FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963968059> ?p ?o ?g. }

• W1963968059 endingPage "204" @default.
• W1963968059 startingPage "196" @default.
• W1963968059 abstract "There is increasing interest in using algorithms combining multiple magnetic resonance imaging (MRI) modalities to predict tissue infarction in acute human stroke. We developed and tested a voxel-based generalized linear model (GLM) algorithm to predict tissue infarction in an animal stroke model in order to directly compare predicted outcome with the tissue's histologic outcome, and to evaluate the potential for assessing therapeutic efficacy using these multiparametric algorithms. With acute MRI acquired after unilateral embolic stroke in rats (n=8), a GLM was developed and used to predict infarction on a voxel-wise basis for saline (n=6) and recombinant tissue plasminogen activator (rt-PA) treatment (n=7) arms of a trial of delayed thrombolytic therapy in rats. Pretreatment predicted outcome compared with post-treatment histology was highly accurate in saline-treated rats (0.92+/-0.05). Accuracy was significantly reduced (P=0.04) in rt-PA-treated animals (0.86+/-0.08), although no significant difference was detected when comparing histologic lesion volumes. Animals that reperfused had significantly lower (P<0.01) GLM-predicted infarction risk (0.73+/-0.03) than nonreperfused animals (0.81+/-0.05), possibly reflecting less severe initial ischemic injury and therefore tissue likely more amenable to therapy. Our results show that acute MRI-based algorithms can predict tissue infarction with high accuracy in animals not receiving thrombolytic therapy. Furthermore, alterations in disease progression due to treatment were more sensitively monitored with our voxel-based analysis techniques than with volumetric approaches. Our study shows that predictive algorithms are promising metrics for diagnosis, prognosis and therapeutic evaluation after acute stroke that can translate readily from preclinical to clinical settings." @default.
• W1963968059 created "2016-06-24" @default.
• W1963968059 creator A5004268054 @default.
• W1963968059 creator A5010029432 @default.
• W1963968059 creator A5035254053 @default.
• W1963968059 creator A5038850257 @default.
• W1963968059 creator A5052069124 @default.
• W1963968059 creator A5069576193 @default.
• W1963968059 creator A5075016511 @default.
• W1963968059 creator A5091447153 @default.
• W1963968059 date "2006-05-10" @default.
• W1963968059 modified "2023-09-23" @default.
• W1963968059 title "Infarct Prediction and Treatment Assessment with MRI-based Algorithms in Experimental Stroke Models" @default.
• W1963968059 cites W1919988544 @default.
• W1963968059 cites W1963755807 @default.
• W1963968059 cites W1969323984 @default.
• W1963968059 cites W1970109090 @default.
• W1963968059 cites W1977877018 @default.
• W1963968059 cites W1983640224 @default.
• W1963968059 cites W1990005524 @default.
• W1963968059 cites W1990049836 @default.
• W1963968059 cites W2008483626 @default.
• W1963968059 cites W2009049939 @default.
• W1963968059 cites W2009436292 @default.
• W1963968059 cites W2014150480 @default.
• W1963968059 cites W2017610706 @default.
• W1963968059 cites W2026704822 @default.
• W1963968059 cites W2031945226 @default.
• W1963968059 cites W2032153246 @default.
• W1963968059 cites W2042267337 @default.
• W1963968059 cites W2046562067 @default.
• W1963968059 cites W2047232697 @default.
• W1963968059 cites W2051257147 @default.
• W1963968059 cites W205495280 @default.
• W1963968059 cites W2063098990 @default.
• W1963968059 cites W2070198884 @default.
• W1963968059 cites W2071984852 @default.
• W1963968059 cites W2073868175 @default.
• W1963968059 cites W2076311323 @default.
• W1963968059 cites W2094526010 @default.
• W1963968059 cites W2099708759 @default.
• W1963968059 cites W2111398333 @default.
• W1963968059 cites W2124181495 @default.
• W1963968059 cites W2126719211 @default.
• W1963968059 cites W2129736986 @default.
• W1963968059 cites W2141210606 @default.
• W1963968059 cites W2144424761 @default.
• W1963968059 cites W2145818505 @default.
• W1963968059 cites W2152575748 @default.
• W1963968059 cites W2156267331 @default.
• W1963968059 cites W2157825442 @default.
• W1963968059 cites W2158533624 @default.
• W1963968059 cites W2292308933 @default.
• W1963968059 cites W2885843438 @default.
• W1963968059 cites W4250104750 @default.
• W1963968059 cites W4297738730 @default.
• W1963968059 doi "https://doi.org/10.1038/sj.jcbfm.9600328" @default.
• W1963968059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16685257" @default.
• W1963968059 hasPublicationYear "2006" @default.
• W1963968059 type Work @default.
• W1963968059 sameAs 1963968059 @default.
• W1963968059 citedByCount "49" @default.
• W1963968059 countsByYear W19639680592012 @default.
• W1963968059 countsByYear W19639680592013 @default.
• W1963968059 countsByYear W19639680592014 @default.
• W1963968059 countsByYear W19639680592015 @default.
• W1963968059 countsByYear W19639680592016 @default.
• W1963968059 countsByYear W19639680592017 @default.
• W1963968059 countsByYear W19639680592018 @default.
• W1963968059 countsByYear W19639680592019 @default.
• W1963968059 countsByYear W19639680592020 @default.
• W1963968059 countsByYear W19639680592021 @default.
• W1963968059 crossrefType "journal-article" @default.
• W1963968059 hasAuthorship W1963968059A5004268054 @default.
• W1963968059 hasAuthorship W1963968059A5010029432 @default.
• W1963968059 hasAuthorship W1963968059A5035254053 @default.
• W1963968059 hasAuthorship W1963968059A5038850257 @default.
• W1963968059 hasAuthorship W1963968059A5052069124 @default.
• W1963968059 hasAuthorship W1963968059A5069576193 @default.
• W1963968059 hasAuthorship W1963968059A5075016511 @default.
• W1963968059 hasAuthorship W1963968059A5091447153 @default.
• W1963968059 hasBestOaLocation W19639680591 @default.
• W1963968059 hasConcept C11413529 @default.
• W1963968059 hasConcept C126322002 @default.
• W1963968059 hasConcept C126838900 @default.
• W1963968059 hasConcept C127413603 @default.
• W1963968059 hasConcept C142724271 @default.
• W1963968059 hasConcept C143409427 @default.
• W1963968059 hasConcept C2776572282 @default.
• W1963968059 hasConcept C2777798775 @default.
• W1963968059 hasConcept C2780645631 @default.
• W1963968059 hasConcept C2781156865 @default.
• W1963968059 hasConcept C2989005 @default.
• W1963968059 hasConcept C33923547 @default.
• W1963968059 hasConcept C500558357 @default.
• W1963968059 hasConcept C54170458 @default.
• W1963968059 hasConcept C71924100 @default.
• W1963968059 hasConcept C78519656 @default.

• next