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- W1963968275 abstract "Alzheimer's disease (AD) is characterized by extracellular deposits of amyloid-β protein which attract dense clusters of microglial cells. Here, we analyzed amyloid plaque-associated areas in aged APP23 transgenic mice, an animal model of AD, by combining laser microdissection with microarray analysis and quantitative RT-PCR (qPCR). By comparing gene expression profiles, we found that 538 genes (1.3% of a total of 41,234 analyzed genes) were differentially expressed in plaque-associated versus plaque-free tissue of aged APP23 transgenic mice. One of these genes is the microglia-associated triggering receptor expressed on myeloid cells (TREM2) which enhances phagocytosis, but abrogates cytokine production as well as TLR and Fc receptor-mediated induction of TNF secretion. Western Blot analysis demonstrated an upregulation of TREM2 protein in APP23 transgenic compared with nontransgenic mice. Confocal imaging studies, furthermore, confirmed colocalization of TREM2 protein with microglia. Thus, when TREM2 is induced on microglia in plaque-loaded brain areas the respective signaling may prevent inflammation-induced bystander damage of neurons. At the same time, TREM2 signaling may also account for the failure to sufficiently eliminate extracellular amyloid with the help of a systemic immune response. © 2008 Wiley-Liss, Inc." @default.
- W1963968275 created "2016-06-24" @default.
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- W1963968275 date "2008-10-01" @default.
- W1963968275 modified "2023-09-24" @default.
- W1963968275 title "TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice" @default.
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- W1963968275 cites W1563590122 @default.
- W1963968275 cites W1583052686 @default.
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- W1963968275 cites W1772351760 @default.
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- W1963968275 cites W2000164527 @default.
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- W1963968275 doi "https://doi.org/10.1002/glia.20710" @default.
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