FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963968986> ?p ?o ?g. }

• W1963968986 endingPage "e1002152" @default.
• W1963968986 startingPage "e1002152" @default.
• W1963968986 abstract "The microsomal, membrane-bound, human cytochrome P450 (CYP) 2C9 is a liver-specific monooxygenase essential for drug metabolism. CYPs require electron transfer from the membrane-bound CYP reductase (CPR) for catalysis. The structural details and functional relevance of the CYP-membrane interaction are not understood. From multiple coarse grained molecular simulations started with arbitrary configurations of protein-membrane complexes, we found two predominant orientations of CYP2C9 in the membrane, both consistent with experiments and conserved in atomic-resolution simulations. The dynamics of membrane-bound and soluble CYP2C9 revealed correlations between opening and closing of different tunnels from the enzyme's buried active site. The membrane facilitated the opening of a tunnel leading into it by stabilizing the open state of an internal aromatic gate. Other tunnels opened selectively in the simulations of product-bound CYP2C9. We propose that the membrane promotes binding of liposoluble substrates by stabilizing protein conformations with an open access tunnel and provide evidence for selective substrate access and product release routes in mammalian CYPs. The models derived here are suitable for extension to incorporate other CYPs for oligomerization studies or the CYP reductase for studies of the electron transfer mechanism, whereas the modeling procedure is generally applicable to study proteins anchored in the bilayer by a single transmembrane helix." @default.
• W1963968986 created "2016-06-24" @default.
• W1963968986 creator A5005498993 @default.
• W1963968986 creator A5015751934 @default.
• W1963968986 creator A5041718990 @default.
• W1963968986 creator A5066917113 @default.
• W1963968986 date "2011-08-11" @default.
• W1963968986 modified "2023-10-18" @default.
• W1963968986 title "Structure and Dynamics of the Membrane-Bound Cytochrome P450 2C9" @default.
• W1963968986 cites W1509553808 @default.
• W1963968986 cites W1872726898 @default.
• W1963968986 cites W1897108458 @default.
• W1963968986 cites W1966078827 @default.
• W1963968986 cites W1967899104 @default.
• W1963968986 cites W1974302220 @default.
• W1963968986 cites W1975206909 @default.
• W1963968986 cites W1981225934 @default.
• W1963968986 cites W1997765587 @default.
• W1963968986 cites W2008807736 @default.
• W1963968986 cites W2016084400 @default.
• W1963968986 cites W2021879075 @default.
• W1963968986 cites W2029667189 @default.
• W1963968986 cites W2035048137 @default.
• W1963968986 cites W2035266068 @default.
• W1963968986 cites W2038028274 @default.
• W1963968986 cites W2039181331 @default.
• W1963968986 cites W2042757390 @default.
• W1963968986 cites W2049286183 @default.
• W1963968986 cites W2051639214 @default.
• W1963968986 cites W2051864856 @default.
• W1963968986 cites W2052299042 @default.
• W1963968986 cites W2052709577 @default.
• W1963968986 cites W2055111899 @default.
• W1963968986 cites W2060097208 @default.
• W1963968986 cites W2065283382 @default.
• W1963968986 cites W2069518737 @default.
• W1963968986 cites W2070098436 @default.
• W1963968986 cites W2078880422 @default.
• W1963968986 cites W2080985792 @default.
• W1963968986 cites W2084546279 @default.
• W1963968986 cites W2092019850 @default.
• W1963968986 cites W2096561572 @default.
• W1963968986 cites W2097334696 @default.
• W1963968986 cites W2097775366 @default.
• W1963968986 cites W2104180764 @default.
• W1963968986 cites W2113524447 @default.
• W1963968986 cites W2125872855 @default.
• W1963968986 cites W2130434638 @default.
• W1963968986 cites W2130983257 @default.
• W1963968986 cites W2142034214 @default.
• W1963968986 cites W2142532813 @default.
• W1963968986 cites W2144288821 @default.
• W1963968986 cites W2145392467 @default.
• W1963968986 cites W2146453159 @default.
• W1963968986 cites W2149573717 @default.
• W1963968986 cites W2150981663 @default.
• W1963968986 cites W2152770371 @default.
• W1963968986 cites W2154598050 @default.
• W1963968986 cites W2167509522 @default.
• W1963968986 cites W2170439793 @default.
• W1963968986 doi "https://doi.org/10.1371/journal.pcbi.1002152" @default.
• W1963968986 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3154944" @default.
• W1963968986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21852944" @default.
• W1963968986 hasPublicationYear "2011" @default.
• W1963968986 type Work @default.
• W1963968986 sameAs 1963968986 @default.
• W1963968986 citedByCount "132" @default.
• W1963968986 countsByYear W19639689862012 @default.
• W1963968986 countsByYear W19639689862013 @default.
• W1963968986 countsByYear W19639689862014 @default.
• W1963968986 countsByYear W19639689862015 @default.
• W1963968986 countsByYear W19639689862016 @default.
• W1963968986 countsByYear W19639689862017 @default.
• W1963968986 countsByYear W19639689862018 @default.
• W1963968986 countsByYear W19639689862019 @default.
• W1963968986 countsByYear W19639689862020 @default.
• W1963968986 countsByYear W19639689862021 @default.
• W1963968986 countsByYear W19639689862022 @default.
• W1963968986 countsByYear W19639689862023 @default.
• W1963968986 crossrefType "journal-article" @default.
• W1963968986 hasAuthorship W1963968986A5005498993 @default.
• W1963968986 hasAuthorship W1963968986A5015751934 @default.
• W1963968986 hasAuthorship W1963968986A5041718990 @default.
• W1963968986 hasAuthorship W1963968986A5066917113 @default.
• W1963968986 hasBestOaLocation W19639689861 @default.
• W1963968986 hasConcept C118892022 @default.
• W1963968986 hasConcept C12554922 @default.
• W1963968986 hasConcept C144647389 @default.
• W1963968986 hasConcept C147597530 @default.
• W1963968986 hasConcept C161200384 @default.
• W1963968986 hasConcept C170493617 @default.
• W1963968986 hasConcept C181199279 @default.
• W1963968986 hasConcept C185592680 @default.
• W1963968986 hasConcept C191120209 @default.
• W1963968986 hasConcept C24530287 @default.
• W1963968986 hasConcept C41183919 @default.
• W1963968986 hasConcept C41625074 @default.
• W1963968986 hasConcept C47701112 @default.

• next