FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963971058> ?p ?o ?g. }

• W1963971058 endingPage "e41340" @default.
• W1963971058 startingPage "e41340" @default.
• W1963971058 abstract "Background Allergic contact dermatitis (ACD) represents a severe health problem with increasing worldwide prevalence. It is a T cell-mediated skin disease induced by protein-reactive organic and inorganic chemicals. A key feature of contact allergens is their ability to trigger an innate immune response that leads to skin inflammation. Previous evidence from the mouse contact hypersensitivity (CHS) model suggests a role for endogenous activators of innate immune signaling. Here, we analyzed the role of contact sensitizer induced ROS production and concomitant changes in hyaluronic acid metabolism on CHS responses. Methodology/Principal Findings We analyzed in vitro and in vivo ROS production using fluorescent ROS detection reagents. HA fragmentation was determined by gel electrophoresis. The influence of blocking ROS production and HA degradation by antioxidants, hyaluronidase-inhibitor or p38 MAPK inhibitor was analyzed in the murine CHS model. Here, we demonstrate that organic contact sensitizers induce production of reactive oxygen species (ROS) and a concomitant breakdown of the extracellular matrix (ECM) component hyaluronic acid (HA) to pro-inflammatory low molecular weight fragments in the skin. Importantly, inhibition of either ROS-mediated or enzymatic HA breakdown prevents sensitization as well as elicitation of CHS. Conclusions/Significance These data identify an indirect mechanism of contact sensitizer induced innate inflammatory signaling involving the breakdown of the ECM and generation of endogenous danger signals. Our findings suggest a beneficial role for anti-oxidants and hyaluronidase inhibitors in prevention and treatment of ACD." @default.
• W1963971058 created "2016-06-24" @default.
• W1963971058 creator A5005190746 @default.
• W1963971058 creator A5007115757 @default.
• W1963971058 creator A5008318113 @default.
• W1963971058 creator A5010607577 @default.
• W1963971058 creator A5044791487 @default.
• W1963971058 creator A5051476956 @default.
• W1963971058 creator A5086936229 @default.
• W1963971058 creator A5089256034 @default.
• W1963971058 date "2012-07-25" @default.
• W1963971058 modified "2023-10-17" @default.
• W1963971058 title "Contact Sensitizers Induce Skin Inflammation via ROS Production and Hyaluronic Acid Degradation" @default.
• W1963971058 cites W1512887313 @default.
• W1963971058 cites W1932984089 @default.
• W1963971058 cites W1963492948 @default.
• W1963971058 cites W1967434989 @default.
• W1963971058 cites W1970935798 @default.
• W1963971058 cites W1970976508 @default.
• W1963971058 cites W1971222243 @default.
• W1963971058 cites W1972992309 @default.
• W1963971058 cites W1985538633 @default.
• W1963971058 cites W1987383242 @default.
• W1963971058 cites W1988760595 @default.
• W1963971058 cites W1996706124 @default.
• W1963971058 cites W2001244523 @default.
• W1963971058 cites W2006721421 @default.
• W1963971058 cites W2009430627 @default.
• W1963971058 cites W2013632991 @default.
• W1963971058 cites W2019111941 @default.
• W1963971058 cites W2019309424 @default.
• W1963971058 cites W2026244707 @default.
• W1963971058 cites W2033177835 @default.
• W1963971058 cites W2036706613 @default.
• W1963971058 cites W2038758843 @default.
• W1963971058 cites W2043958179 @default.
• W1963971058 cites W2045969462 @default.
• W1963971058 cites W2046860633 @default.
• W1963971058 cites W2050333516 @default.
• W1963971058 cites W2051563649 @default.
• W1963971058 cites W2052169767 @default.
• W1963971058 cites W2058006404 @default.
• W1963971058 cites W2061626698 @default.
• W1963971058 cites W2073214088 @default.
• W1963971058 cites W2078073042 @default.
• W1963971058 cites W2080298383 @default.
• W1963971058 cites W2081002915 @default.
• W1963971058 cites W2084958392 @default.
• W1963971058 cites W2085354713 @default.
• W1963971058 cites W2086340031 @default.
• W1963971058 cites W2089723196 @default.
• W1963971058 cites W2092763100 @default.
• W1963971058 cites W2092894443 @default.
• W1963971058 cites W2097847761 @default.
• W1963971058 cites W2099356631 @default.
• W1963971058 cites W2100252473 @default.
• W1963971058 cites W2113668357 @default.
• W1963971058 cites W2114269157 @default.
• W1963971058 cites W2116474923 @default.
• W1963971058 cites W2116867036 @default.
• W1963971058 cites W2117626573 @default.
• W1963971058 cites W2118755647 @default.
• W1963971058 cites W2119725719 @default.
• W1963971058 cites W2120815988 @default.
• W1963971058 cites W2126659405 @default.
• W1963971058 cites W2128246218 @default.
• W1963971058 cites W2137630610 @default.
• W1963971058 cites W2138083101 @default.
• W1963971058 cites W2144032514 @default.
• W1963971058 cites W2155036200 @default.
• W1963971058 cites W2162536072 @default.
• W1963971058 cites W2171005142 @default.
• W1963971058 cites W96929193 @default.
• W1963971058 doi "https://doi.org/10.1371/journal.pone.0041340" @default.
• W1963971058 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3405137" @default.
• W1963971058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22848468" @default.
• W1963971058 hasPublicationYear "2012" @default.
• W1963971058 type Work @default.
• W1963971058 sameAs 1963971058 @default.
• W1963971058 citedByCount "152" @default.
• W1963971058 countsByYear W19639710582012 @default.
• W1963971058 countsByYear W19639710582013 @default.
• W1963971058 countsByYear W19639710582014 @default.
• W1963971058 countsByYear W19639710582015 @default.
• W1963971058 countsByYear W19639710582016 @default.
• W1963971058 countsByYear W19639710582017 @default.
• W1963971058 countsByYear W19639710582018 @default.
• W1963971058 countsByYear W19639710582019 @default.
• W1963971058 countsByYear W19639710582020 @default.
• W1963971058 countsByYear W19639710582021 @default.
• W1963971058 countsByYear W19639710582022 @default.
• W1963971058 countsByYear W19639710582023 @default.
• W1963971058 crossrefType "journal-article" @default.
• W1963971058 hasAuthorship W1963971058A5005190746 @default.
• W1963971058 hasAuthorship W1963971058A5007115757 @default.
• W1963971058 hasAuthorship W1963971058A5008318113 @default.
• W1963971058 hasAuthorship W1963971058A5010607577 @default.
• W1963971058 hasAuthorship W1963971058A5044791487 @default.

• next