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• W1963973293 abstract "We performed label-free observation of molecular dynamics in apoptotic cells by Raman microscopy. Dynamic changes in cytochrome c distribution at the Raman band of 750 cm -1 were observed after adding an apoptosis inducer to the cells. The comparison of mitochondria fluorescence images and Raman images of cytochrome c confirmed that changes in cytochrome c distribution can be distinguished as release of cytochrome c from mitochondria. Our observation also revealed that the redox state of cytochrome c was maintained during the release from the mitochondria. Monitoring mitochondrial membrane potential with JC-1 dye confirmed that the observed cytochrome c release was associated with apoptosis." @default.
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• W1963973293 date "2011-12-19" @default.
• W1963973293 modified "2023-10-18" @default.
• W1963973293 title "Label-free Raman observation of cytochrome c dynamics during apoptosis" @default.
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• W1963973293 doi "https://doi.org/10.1073/pnas.1107524108" @default.
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