FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963974600> ?p ?o ?g. }

• W1963974600 endingPage "2152" @default.
• W1963974600 startingPage "2146" @default.
• W1963974600 abstract "Nuclear transport proteins such as CSE1, NUP93 and Importin-alpha have recently been shown to be chromatin-associated proteins in yeast, which have unexpected functions in gene regulation. Here we report interactions between the mammalian histone acetyltransferase CBP with nuclear transport proteins CAS (a CSE1 homologue) and Importin-alpha (Impalpha) and NUP93. CAS was found to bind the SRC1 interaction domain (SID) of CBP via a leucine-rich motif in the N-terminus of the protein, that is conserved in other SID-binding proteins. Coimmunoprecipitation experiments also revealed that CBP and Impalpha proteins form a complex. As Impalpha is a known acetylation target of CBP/p300, and is recycled to the cytoplasm via the exportin CAS, we investigated whether HDAC inhibitors would alter the subcellular localization of these proteins. Treatment of COS-1 cells with the HDAC inhibitors trichostatin A or sodium butyrate resulted in sequestration of Impalpha in the nuclear envelope, accumulation of CAS in nuclear aggregates, and an increased number of CBP-containing PML bodies per cell. In addition, HDACi treatment appeared to enhance the association of Impalpha and CBP in coimmunoprecipitation experiments. Our results provide evidence for novel functional interactions between the chromatin modification enzyme CBP and nuclear transport proteins in mammalian cells." @default.
• W1963974600 created "2016-06-24" @default.
• W1963974600 creator A5003104227 @default.
• W1963974600 creator A5014627305 @default.
• W1963974600 creator A5023352253 @default.
• W1963974600 creator A5062222101 @default.
• W1963974600 creator A5070367173 @default.
• W1963974600 date "2006-09-12" @default.
• W1963974600 modified "2023-10-04" @default.
• W1963974600 title "Functional Interaction of CREB Binding Protein (CBP) with Nuclear Transport Proteins and Modulation by HDAC Inhibitors" @default.
• W1963974600 cites W1515930873 @default.
• W1963974600 cites W1971794652 @default.
• W1963974600 cites W1989448155 @default.
• W1963974600 cites W1991018390 @default.
• W1963974600 cites W1994598776 @default.
• W1963974600 cites W2006305989 @default.
• W1963974600 cites W2010912571 @default.
• W1963974600 cites W2011730857 @default.
• W1963974600 cites W2013715448 @default.
• W1963974600 cites W2016132852 @default.
• W1963974600 cites W2017204495 @default.
• W1963974600 cites W2019923915 @default.
• W1963974600 cites W2024237172 @default.
• W1963974600 cites W2030571655 @default.
• W1963974600 cites W2036354732 @default.
• W1963974600 cites W2036565444 @default.
• W1963974600 cites W2043545670 @default.
• W1963974600 cites W2049433808 @default.
• W1963974600 cites W2051026285 @default.
• W1963974600 cites W2051152566 @default.
• W1963974600 cites W2058402081 @default.
• W1963974600 cites W2058840052 @default.
• W1963974600 cites W2073925624 @default.
• W1963974600 cites W2074362522 @default.
• W1963974600 cites W2078724625 @default.
• W1963974600 cites W2092722802 @default.
• W1963974600 cites W2095615304 @default.
• W1963974600 cites W2099489928 @default.
• W1963974600 cites W2100747051 @default.
• W1963974600 cites W2115396907 @default.
• W1963974600 cites W2141686420 @default.
• W1963974600 cites W2142442530 @default.
• W1963974600 cites W2146385874 @default.
• W1963974600 cites W2150167566 @default.
• W1963974600 cites W2153489372 @default.
• W1963974600 cites W2156712995 @default.
• W1963974600 cites W2156961771 @default.
• W1963974600 cites W2158025924 @default.
• W1963974600 cites W2165299990 @default.
• W1963974600 cites W2411975938 @default.
• W1963974600 doi "https://doi.org/10.4161/cc.5.18.3207" @default.
• W1963974600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16969114" @default.
• W1963974600 hasPublicationYear "2006" @default.
• W1963974600 type Work @default.
• W1963974600 sameAs 1963974600 @default.
• W1963974600 citedByCount "24" @default.
• W1963974600 countsByYear W19639746002012 @default.
• W1963974600 countsByYear W19639746002013 @default.
• W1963974600 countsByYear W19639746002014 @default.
• W1963974600 countsByYear W19639746002015 @default.
• W1963974600 countsByYear W19639746002016 @default.
• W1963974600 countsByYear W19639746002018 @default.
• W1963974600 countsByYear W19639746002019 @default.
• W1963974600 countsByYear W19639746002020 @default.
• W1963974600 countsByYear W19639746002021 @default.
• W1963974600 crossrefType "journal-article" @default.
• W1963974600 hasAuthorship W1963974600A5003104227 @default.
• W1963974600 hasAuthorship W1963974600A5014627305 @default.
• W1963974600 hasAuthorship W1963974600A5023352253 @default.
• W1963974600 hasAuthorship W1963974600A5062222101 @default.
• W1963974600 hasAuthorship W1963974600A5070367173 @default.
• W1963974600 hasBestOaLocation W19639746001 @default.
• W1963974600 hasConcept C104317684 @default.
• W1963974600 hasConcept C126725582 @default.
• W1963974600 hasConcept C133882971 @default.
• W1963974600 hasConcept C1629964 @default.
• W1963974600 hasConcept C190062978 @default.
• W1963974600 hasConcept C2776603820 @default.
• W1963974600 hasConcept C2777336224 @default.
• W1963974600 hasConcept C2777865847 @default.
• W1963974600 hasConcept C2778305200 @default.
• W1963974600 hasConcept C2780114586 @default.
• W1963974600 hasConcept C29512474 @default.
• W1963974600 hasConcept C55493867 @default.
• W1963974600 hasConcept C59157529 @default.
• W1963974600 hasConcept C64927066 @default.
• W1963974600 hasConcept C83640560 @default.
• W1963974600 hasConcept C86339819 @default.
• W1963974600 hasConcept C86803240 @default.
• W1963974600 hasConcept C87026931 @default.
• W1963974600 hasConcept C95444343 @default.
• W1963974600 hasConceptScore W1963974600C104317684 @default.
• W1963974600 hasConceptScore W1963974600C126725582 @default.
• W1963974600 hasConceptScore W1963974600C133882971 @default.
• W1963974600 hasConceptScore W1963974600C1629964 @default.
• W1963974600 hasConceptScore W1963974600C190062978 @default.
• W1963974600 hasConceptScore W1963974600C2776603820 @default.
• W1963974600 hasConceptScore W1963974600C2777336224 @default.

• next