SemOpenAlex |

SemOpenAlex

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963976924> ?p ?o ?g. }

Showing items 1 to 100 of ±144 with 100 items per page.

W1963976924 endingPage "e85840" @default.
W1963976924 startingPage "e85840" @default.
W1963976924 abstract "Nodal, a TGF-β-related embryonic morphogen, is involved in multiple biologic processes. However, the expression of Nodal in hepatocellular carcinoma (HCC) and its correlation with tumor angiogenesis, epithelial-mesenchymal transition, and prognosis is unclear.We used real-time PCR and Western blotting to investigate Nodal expression in 6 HCC cell lines and 1 normal liver cell line, 16 pairs of tumor and corresponding paracarcinomatous tissues from HCC patients. Immunohistochemistry was performed to examine Nodal expression in HCC and corresponding paracarcinomatous tissues from 96 patients. CD34 and Vimentin were only examined in HCC tissues of patients mentioned above. Nodal gene was silenced by shRNA in MHCC97H and HCCLM3 cell lines, and cell migration and invasion were detected. Statistical analyses were applied to evaluate the prognostic value and associations of Nodal expression with clinical parameters.Nodal expression was detected in HCC cell lines with high metastatic potential alone. Nodal expression is up-regulated in HCC tissues compared with paracarcinomatous and normal liver tissues. Nodal protein was expressed in 70 of the 96 (72.9%) HCC tumors, and was associated with vascular invasion (P = 0.000), status of metastasis (P = 0.004), AFP (P = 0.049), ICGR15 (indocyanine green retention rate at 15 min) (P = 0.010) and tumor size (P = 0.000). High Nodal expression was positively correlated with high MVD (microvessal density) (P = 0.006), but not with Vimentin expression (P = 0.053). Significantly fewer migrated and invaded cells were seen in shRNA group compared with blank group and negative control group (P<0.05). High Nodal expression was found to be an independent factor for predicting overall survival of HCC.Our study demonstrated that Nodal expression is associated with aggressive characteristics of HCC. Its aberrant expression may be a predictive factor of unfavorable prognosis for HCC after surgery." @default.
W1963976924 created "2016-06-24" @default.
W1963976924 creator A5015741830 @default.
W1963976924 creator A5028012159 @default.
W1963976924 creator A5032159354 @default.
W1963976924 creator A5033497327 @default.
W1963976924 creator A5034272114 @default.
W1963976924 creator A5048379858 @default.
W1963976924 creator A5061065826 @default.
W1963976924 creator A5065567575 @default.
W1963976924 creator A5072480558 @default.
W1963976924 creator A5090460589 @default.
W1963976924 date "2014-01-21" @default.
W1963976924 modified "2023-10-01" @default.
W1963976924 title "Embryonic Morphogen Nodal Is Associated with Progression and Poor Prognosis of Hepatocellular Carcinoma" @default.
W1963976924 cites W1496148293 @default.
W1963976924 cites W1513929030 @default.
W1963976924 cites W1528219829 @default.
W1963976924 cites W1964829819 @default.
W1963976924 cites W1969487624 @default.
W1963976924 cites W1986792117 @default.
W1963976924 cites W1988783376 @default.
W1963976924 cites W1989874642 @default.
W1963976924 cites W1990402395 @default.
W1963976924 cites W1991656327 @default.
W1963976924 cites W2011035258 @default.
W1963976924 cites W2013480667 @default.
W1963976924 cites W2013554656 @default.
W1963976924 cites W2028661474 @default.
W1963976924 cites W2029082826 @default.
W1963976924 cites W2034683528 @default.
W1963976924 cites W2036832569 @default.
W1963976924 cites W2061943708 @default.
W1963976924 cites W2063220206 @default.
W1963976924 cites W2068286169 @default.
W1963976924 cites W2076583198 @default.
W1963976924 cites W2096939974 @default.
W1963976924 cites W2106787323 @default.
W1963976924 cites W2109389570 @default.
W1963976924 cites W2117692326 @default.
W1963976924 cites W2142540639 @default.
W1963976924 cites W2147350988 @default.
W1963976924 cites W2149627453 @default.
W1963976924 cites W2157190251 @default.
W1963976924 cites W2319962899 @default.
W1963976924 cites W4211028684 @default.
W1963976924 cites W4211105405 @default.
W1963976924 doi "https://doi.org/10.1371/journal.pone.0085840" @default.
W1963976924 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3897529" @default.
W1963976924 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24465741" @default.
W1963976924 hasPublicationYear "2014" @default.
W1963976924 type Work @default.
W1963976924 sameAs 1963976924 @default.
W1963976924 citedByCount "20" @default.
W1963976924 countsByYear W19639769242015 @default.
W1963976924 countsByYear W19639769242016 @default.
W1963976924 countsByYear W19639769242017 @default.
W1963976924 countsByYear W19639769242019 @default.
W1963976924 countsByYear W19639769242020 @default.
W1963976924 countsByYear W19639769242021 @default.
W1963976924 countsByYear W19639769242022 @default.
W1963976924 crossrefType "journal-article" @default.
W1963976924 hasAuthorship W1963976924A5015741830 @default.
W1963976924 hasAuthorship W1963976924A5028012159 @default.
W1963976924 hasAuthorship W1963976924A5032159354 @default.
W1963976924 hasAuthorship W1963976924A5033497327 @default.
W1963976924 hasAuthorship W1963976924A5034272114 @default.
W1963976924 hasAuthorship W1963976924A5048379858 @default.
W1963976924 hasAuthorship W1963976924A5061065826 @default.
W1963976924 hasAuthorship W1963976924A5065567575 @default.
W1963976924 hasAuthorship W1963976924A5072480558 @default.
W1963976924 hasAuthorship W1963976924A5090460589 @default.
W1963976924 hasBestOaLocation W19639769241 @default.
W1963976924 hasConcept C10205521 @default.
W1963976924 hasConcept C104317684 @default.
W1963976924 hasConcept C121608353 @default.
W1963976924 hasConcept C126322002 @default.
W1963976924 hasConcept C129536746 @default.
W1963976924 hasConcept C142724271 @default.
W1963976924 hasConcept C145103041 @default.
W1963976924 hasConcept C147447768 @default.
W1963976924 hasConcept C173396325 @default.
W1963976924 hasConcept C190232843 @default.
W1963976924 hasConcept C204232928 @default.
W1963976924 hasConcept C205583638 @default.
W1963976924 hasConcept C2778019345 @default.
W1963976924 hasConcept C2779013556 @default.
W1963976924 hasConcept C2780394083 @default.
W1963976924 hasConcept C28328180 @default.
W1963976924 hasConcept C502942594 @default.
W1963976924 hasConcept C54355233 @default.
W1963976924 hasConcept C55493867 @default.
W1963976924 hasConcept C71924100 @default.
W1963976924 hasConcept C81885089 @default.
W1963976924 hasConcept C83330619 @default.
W1963976924 hasConcept C86803240 @default.
W1963976924 hasConceptScore W1963976924C10205521 @default.
W1963976924 hasConceptScore W1963976924C104317684 @default.