FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963978275> ?p ?o ?g. }

• W1963978275 endingPage "581" @default.
• W1963978275 startingPage "575" @default.
• W1963978275 abstract "This paper describes the synthesis of racemic 3,5-dihydro-5-methyl-7,8-methylenedioxy-4H-2,3-benzodiazepin-4-one (+/-)-5, attempted stereoselective synthesis of its enantiomers, chiral HPLC resolution of the racemate, and assignment of the absolute configuration. Enantiomer (5S)-(-)-5 is provided with an in vivo anticonvulsant activity 8 times higher than its enantiomer (5R)-(+)-5. This result is confirmed in the in vitro test by the ability to inhibit the kainate-induced increase of the [Ca(2+)](i) in a primary culture of rat cerebellar granule cells which express alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors. Binding affinity of compound (+/-)-5 at the AMPA and N-methyl-d-aspartic acid (NMDA) receptors was also evaluated." @default.
• W1963978275 created "2016-06-24" @default.
• W1963978275 creator A5010004061 @default.
• W1963978275 creator A5013096980 @default.
• W1963978275 creator A5018085259 @default.
• W1963978275 creator A5049966462 @default.
• W1963978275 creator A5063112917 @default.
• W1963978275 creator A5064215664 @default.
• W1963978275 creator A5065852754 @default.
• W1963978275 creator A5072558415 @default.
• W1963978275 creator A5081280580 @default.
• W1963978275 creator A5086505931 @default.
• W1963978275 date "2005-12-16" @default.
• W1963978275 modified "2023-10-18" @default.
• W1963978275 title "Synthesis, Chiral Resolution, and Enantiopharmacology of a Potent 2,3-Benzodiazepine Derivative as Noncompetitive AMPA Receptor Antagonist" @default.
• W1963978275 cites W1586538107 @default.
• W1963978275 cites W1989363688 @default.
• W1963978275 cites W1997725714 @default.
• W1963978275 cites W1998759411 @default.
• W1963978275 cites W2010417355 @default.
• W1963978275 cites W2018154074 @default.
• W1963978275 cites W2045215065 @default.
• W1963978275 cites W2049397741 @default.
• W1963978275 cites W2054902345 @default.
• W1963978275 cites W2056749237 @default.
• W1963978275 cites W2059851961 @default.
• W1963978275 cites W2077182652 @default.
• W1963978275 cites W2080685488 @default.
• W1963978275 cites W2080950177 @default.
• W1963978275 cites W2095474273 @default.
• W1963978275 cites W2120884409 @default.
• W1963978275 cites W2338121316 @default.
• W1963978275 doi "https://doi.org/10.1021/jm050552y" @default.
• W1963978275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16420043" @default.
• W1963978275 hasPublicationYear "2005" @default.
• W1963978275 type Work @default.
• W1963978275 sameAs 1963978275 @default.
• W1963978275 citedByCount "34" @default.
• W1963978275 countsByYear W19639782752012 @default.
• W1963978275 countsByYear W19639782752013 @default.
• W1963978275 countsByYear W19639782752014 @default.
• W1963978275 countsByYear W19639782752016 @default.
• W1963978275 countsByYear W19639782752017 @default.
• W1963978275 countsByYear W19639782752018 @default.
• W1963978275 countsByYear W19639782752019 @default.
• W1963978275 countsByYear W19639782752020 @default.
• W1963978275 countsByYear W19639782752021 @default.
• W1963978275 countsByYear W19639782752022 @default.
• W1963978275 crossrefType "journal-article" @default.
• W1963978275 hasAuthorship W1963978275A5010004061 @default.
• W1963978275 hasAuthorship W1963978275A5013096980 @default.
• W1963978275 hasAuthorship W1963978275A5018085259 @default.
• W1963978275 hasAuthorship W1963978275A5049966462 @default.
• W1963978275 hasAuthorship W1963978275A5063112917 @default.
• W1963978275 hasAuthorship W1963978275A5064215664 @default.
• W1963978275 hasAuthorship W1963978275A5065852754 @default.
• W1963978275 hasAuthorship W1963978275A5072558415 @default.
• W1963978275 hasAuthorship W1963978275A5081280580 @default.
• W1963978275 hasAuthorship W1963978275A5086505931 @default.
• W1963978275 hasConcept C114373084 @default.
• W1963978275 hasConcept C160268369 @default.
• W1963978275 hasConcept C16838498 @default.
• W1963978275 hasConcept C170493617 @default.
• W1963978275 hasConcept C185592680 @default.
• W1963978275 hasConcept C189184402 @default.
• W1963978275 hasConcept C202751555 @default.
• W1963978275 hasConcept C2776885963 @default.
• W1963978275 hasConcept C2781269603 @default.
• W1963978275 hasConcept C486523 @default.
• W1963978275 hasConcept C55493867 @default.
• W1963978275 hasConcept C67018056 @default.
• W1963978275 hasConcept C71240020 @default.
• W1963978275 hasConceptScore W1963978275C114373084 @default.
• W1963978275 hasConceptScore W1963978275C160268369 @default.
• W1963978275 hasConceptScore W1963978275C16838498 @default.
• W1963978275 hasConceptScore W1963978275C170493617 @default.
• W1963978275 hasConceptScore W1963978275C185592680 @default.
• W1963978275 hasConceptScore W1963978275C189184402 @default.
• W1963978275 hasConceptScore W1963978275C202751555 @default.
• W1963978275 hasConceptScore W1963978275C2776885963 @default.
• W1963978275 hasConceptScore W1963978275C2781269603 @default.
• W1963978275 hasConceptScore W1963978275C486523 @default.
• W1963978275 hasConceptScore W1963978275C55493867 @default.
• W1963978275 hasConceptScore W1963978275C67018056 @default.
• W1963978275 hasConceptScore W1963978275C71240020 @default.
• W1963978275 hasIssue "2" @default.
• W1963978275 hasLocation W19639782751 @default.
• W1963978275 hasLocation W19639782752 @default.
• W1963978275 hasOpenAccess W1963978275 @default.
• W1963978275 hasPrimaryLocation W19639782751 @default.
• W1963978275 hasRelatedWork W1963978275 @default.
• W1963978275 hasRelatedWork W1998177301 @default.
• W1963978275 hasRelatedWork W2007202548 @default.
• W1963978275 hasRelatedWork W2025676835 @default.
• W1963978275 hasRelatedWork W2027503277 @default.
• W1963978275 hasRelatedWork W2038917760 @default.
• W1963978275 hasRelatedWork W2051823921 @default.
• W1963978275 hasRelatedWork W2056933680 @default.

• next