FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963983446> ?p ?o ?g. }

• W1963983446 endingPage "294" @default.
• W1963983446 startingPage "287" @default.
• W1963983446 abstract "Dissolution of the inorganic bone matrix releases not only calcium and phosphate ions, but also bicarbonate. Electroneutral sodium-bicarbonate co-transporter (NBCn1) is expressed in inactive osteoclasts, but its physiological role in bone resorption has remained unknown. We show here that NBCn1, encoded by the SLC4A7 gene, is directly involved in bone resorption. NBCn1 protein was specifically found at the bone-facing ruffled border areas, and metabolic acidosis increased NBCn1 expression in rats in vivo. In human hematopoietic stem cell cultures, NBCn1 mRNA expression was observed only after formation of resorbing osteoclasts. To further confirm the critical role of NBCn1 during bone resorption, human hematopoietic stem cells were transduced with SLC4A7 shRNA lentiviral particles. Downregulation of NBCn1 both on mRNA and protein level by lentiviral shRNAs significantly inhibited bone resorption and increased intracellular acidification in osteoclasts. The lentiviral particles did not impair osteoclast survival, or differentiation of the hematopoietic or mesenchymal precursor cells into osteoclasts or osteoblasts in vitro. Inhibition of NBCn1 activity may thus provide a new way to regulate osteoclast activity during pathological bone resorption." @default.
• W1963983446 created "2016-06-24" @default.
• W1963983446 creator A5005305426 @default.
• W1963983446 creator A5018081386 @default.
• W1963983446 creator A5020150304 @default.
• W1963983446 creator A5022185093 @default.
• W1963983446 creator A5038762754 @default.
• W1963983446 date "2010-05-01" @default.
• W1963983446 modified "2023-10-16" @default.
• W1963983446 title "Degradation of hydroxyapatite in vivo and in vitro requires osteoclastic sodium-bicarbonate co-transporter NBCn1" @default.
• W1963983446 cites W1567965797 @default.
• W1963983446 cites W1576287549 @default.
• W1963983446 cites W1627569217 @default.
• W1963983446 cites W1906025505 @default.
• W1963983446 cites W1967585865 @default.
• W1963983446 cites W1976299751 @default.
• W1963983446 cites W1982166700 @default.
• W1963983446 cites W1988197962 @default.
• W1963983446 cites W1989670756 @default.
• W1963983446 cites W1995614291 @default.
• W1963983446 cites W1996499484 @default.
• W1963983446 cites W1999826236 @default.
• W1963983446 cites W2003395652 @default.
• W1963983446 cites W2010280268 @default.
• W1963983446 cites W2011498236 @default.
• W1963983446 cites W2019490564 @default.
• W1963983446 cites W2020035962 @default.
• W1963983446 cites W2022157009 @default.
• W1963983446 cites W2030027802 @default.
• W1963983446 cites W2032659134 @default.
• W1963983446 cites W2038400016 @default.
• W1963983446 cites W2041006056 @default.
• W1963983446 cites W2041265494 @default.
• W1963983446 cites W2041455826 @default.
• W1963983446 cites W2065442116 @default.
• W1963983446 cites W2066190192 @default.
• W1963983446 cites W2069505287 @default.
• W1963983446 cites W2076955734 @default.
• W1963983446 cites W2077386452 @default.
• W1963983446 cites W2078332345 @default.
• W1963983446 cites W2081410303 @default.
• W1963983446 cites W2086195313 @default.
• W1963983446 cites W2087869826 @default.
• W1963983446 cites W2090977690 @default.
• W1963983446 cites W2092166192 @default.
• W1963983446 cites W2092458882 @default.
• W1963983446 cites W2093814876 @default.
• W1963983446 cites W2095349048 @default.
• W1963983446 cites W2096999463 @default.
• W1963983446 cites W2106091071 @default.
• W1963983446 cites W2107277218 @default.
• W1963983446 cites W2111489159 @default.
• W1963983446 cites W2128520952 @default.
• W1963983446 cites W2130909570 @default.
• W1963983446 cites W2132642631 @default.
• W1963983446 cites W2142919239 @default.
• W1963983446 cites W2143563671 @default.
• W1963983446 cites W2144489801 @default.
• W1963983446 cites W2149573007 @default.
• W1963983446 cites W2149674234 @default.
• W1963983446 cites W2149945930 @default.
• W1963983446 cites W2152765106 @default.
• W1963983446 cites W2157119615 @default.
• W1963983446 cites W2160953172 @default.
• W1963983446 cites W2164490070 @default.
• W1963983446 cites W2335245973 @default.
• W1963983446 cites W2338006860 @default.
• W1963983446 cites W2414142132 @default.
• W1963983446 cites W2494523089 @default.
• W1963983446 doi "https://doi.org/10.1016/j.matbio.2010.01.003" @default.
• W1963983446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20079835" @default.
• W1963983446 hasPublicationYear "2010" @default.
• W1963983446 type Work @default.
• W1963983446 sameAs 1963983446 @default.
• W1963983446 citedByCount "35" @default.
• W1963983446 countsByYear W19639834462012 @default.
• W1963983446 countsByYear W19639834462013 @default.
• W1963983446 countsByYear W19639834462014 @default.
• W1963983446 countsByYear W19639834462015 @default.
• W1963983446 countsByYear W19639834462016 @default.
• W1963983446 countsByYear W19639834462017 @default.
• W1963983446 countsByYear W19639834462018 @default.
• W1963983446 countsByYear W19639834462019 @default.
• W1963983446 countsByYear W19639834462020 @default.
• W1963983446 countsByYear W19639834462021 @default.
• W1963983446 countsByYear W19639834462022 @default.
• W1963983446 countsByYear W19639834462023 @default.
• W1963983446 crossrefType "journal-article" @default.
• W1963983446 hasAuthorship W1963983446A5005305426 @default.
• W1963983446 hasAuthorship W1963983446A5018081386 @default.
• W1963983446 hasAuthorship W1963983446A5020150304 @default.
• W1963983446 hasAuthorship W1963983446A5022185093 @default.
• W1963983446 hasAuthorship W1963983446A5038762754 @default.
• W1963983446 hasConcept C104317684 @default.
• W1963983446 hasConcept C126322002 @default.
• W1963983446 hasConcept C127561419 @default.
• W1963983446 hasConcept C134018914 @default.
• W1963983446 hasConcept C146562846 @default.

• next