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- W1963988594 abstract "Patients with schizophrenia exhibit disturbances in information processing. These disturbances can be investigated with different paradigms of auditory event related potentials (ERP), such as sensory gating in a double click paradigm (P50 suppression) and the mismatch negativity (MMN) component in an auditory oddball paradigm. The aim of the current study was to test if rats subjected to social isolation, which is believed to induce some changes that mimic features of schizophrenia, displays alterations in sensory gating and MMN-like response. Male Lister-Hooded rats were separated into two groups; one group socially isolated (SI) for 8 weeks and one group housed (GH). Both groups were then tested in a double click sensory gating paradigm and an auditory oddball paradigm (MMN-like) paradigm. It was observed that the SI animals showed reduced sensory gating of the cortical N1 amplitude. Furthermore, the SI animals showed significant reduction in cortical MMN-like response compared with the GH animals. No deficits in sensory gating or MMN-like response were observed in the hippocampus (CA3) of the SI animals compared with GH animals. In conclusion, the change in sensory gating of the N1 amplitude supports previous findings in SI rats and the reduced MMN-like response is similar to the deficits of MMN seen in patients with schizophrenia. Since reduced auditory MMN amplitude is believed to be more selectively associated with schizophrenia than other measures of sensory gating deficits, the current study supports the face validity of the SI reared rat model for schizophrenia." @default.
- W1963988594 created "2016-06-24" @default.
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- W1963988594 date "2014-06-01" @default.
- W1963988594 modified "2023-09-27" @default.
- W1963988594 title "Auditory sensory processing deficits in sensory gating and mismatch negativity-like responses in the social isolation rat model of schizophrenia" @default.
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- W1963988594 cites W1643478577 @default.
- W1963988594 cites W1965735691 @default.
- W1963988594 cites W1965997635 @default.
- W1963988594 cites W1966480770 @default.
- W1963988594 cites W1969929244 @default.
- W1963988594 cites W1972740698 @default.
- W1963988594 cites W1976676889 @default.
- W1963988594 cites W1979029926 @default.
- W1963988594 cites W1981359380 @default.
- W1963988594 cites W1992297215 @default.
- W1963988594 cites W1993018409 @default.
- W1963988594 cites W1996362121 @default.
- W1963988594 cites W1997129578 @default.
- W1963988594 cites W2000409641 @default.
- W1963988594 cites W2002313059 @default.
- W1963988594 cites W2004011969 @default.
- W1963988594 cites W2004699872 @default.
- W1963988594 cites W2004721650 @default.
- W1963988594 cites W2004767248 @default.
- W1963988594 cites W2005627695 @default.
- W1963988594 cites W2010163426 @default.
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- W1963988594 cites W2023199657 @default.
- W1963988594 cites W2024186806 @default.
- W1963988594 cites W2025925785 @default.
- W1963988594 cites W2032254540 @default.
- W1963988594 cites W2036191822 @default.
- W1963988594 cites W2036454306 @default.
- W1963988594 cites W2036859828 @default.
- W1963988594 cites W2039081480 @default.
- W1963988594 cites W2039463270 @default.
- W1963988594 cites W2044557200 @default.
- W1963988594 cites W2047437656 @default.
- W1963988594 cites W2047877800 @default.
- W1963988594 cites W2047947014 @default.
- W1963988594 cites W2048027719 @default.
- W1963988594 cites W2052956331 @default.
- W1963988594 cites W2055286116 @default.
- W1963988594 cites W2058368564 @default.
- W1963988594 cites W2060474957 @default.
- W1963988594 cites W2060884332 @default.
- W1963988594 cites W2061703777 @default.
- W1963988594 cites W2066546532 @default.
- W1963988594 cites W2068285319 @default.
- W1963988594 cites W2068711475 @default.
- W1963988594 cites W2076231092 @default.
- W1963988594 cites W2076974641 @default.
- W1963988594 cites W2084537640 @default.
- W1963988594 cites W2085003408 @default.
- W1963988594 cites W2087345301 @default.
- W1963988594 cites W2090982878 @default.
- W1963988594 cites W2091032880 @default.
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- W1963988594 cites W2095308610 @default.
- W1963988594 cites W2104049715 @default.
- W1963988594 cites W2107094155 @default.
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- W1963988594 cites W2120982699 @default.
- W1963988594 cites W2124081491 @default.
- W1963988594 cites W2125206183 @default.
- W1963988594 cites W2132218777 @default.
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- W1963988594 cites W2164713150 @default.
- W1963988594 cites W2314541857 @default.
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- W1963988594 doi "https://doi.org/10.1016/j.bbr.2014.02.048" @default.
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