Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963992862> ?p ?o ?g. }
- W1963992862 endingPage "175" @default.
- W1963992862 startingPage "167" @default.
- W1963992862 abstract "Cerebral arteriovenous malformations (AVMs) entail a significant risk of intracerebral hemorrhage owing to the direct shunting of arterial blood into the venous vasculature without the dissipation of the arterial blood pressure. The mechanisms involved in the growth, progression and rupture of AVMs are not clearly understood, but a number of studies point to inflammation as a major contributor to their pathogenesis. The upregulation of proinflammatory cytokines induces the overexpression of cell adhesion molecules in AVM endothelial cells, resulting in enhanced recruitment of leukocytes. The increased leukocyte-derived release of metalloproteinase-9 is known to damage AVM walls and lead to rupture. Inflammation is also involved in altering the AVM angioarchitecture via the upregulation of angiogenic factors that affect endothelial cell proliferation, migration and apoptosis. The effects of inflammation on AVM pathogenesis are potentiated by certain single-nucleotide polymorphisms in the genes of proinflammatory cytokines, increasing their protein levels in the AVM tissue. Furthermore, studies on metalloproteinase-9 inhibitors and on the involvement of Notch signaling in AVMs provide promising data for a potential basis for pharmacological treatment of AVMs. Potential therapeutic targets and areas requiring further investigation are highlighted." @default.
- W1963992862 created "2016-06-24" @default.
- W1963992862 creator A5004062581 @default.
- W1963992862 creator A5030396271 @default.
- W1963992862 creator A5032611464 @default.
- W1963992862 creator A5042652350 @default.
- W1963992862 creator A5051627945 @default.
- W1963992862 creator A5053649545 @default.
- W1963992862 creator A5053752894 @default.
- W1963992862 creator A5059146591 @default.
- W1963992862 creator A5061484429 @default.
- W1963992862 creator A5067912617 @default.
- W1963992862 creator A5072023956 @default.
- W1963992862 creator A5088068783 @default.
- W1963992862 creator A5089204541 @default.
- W1963992862 date "2014-11-19" @default.
- W1963992862 modified "2023-10-14" @default.
- W1963992862 title "Biology of Cerebral Arteriovenous Malformations with a Focus on Inflammation" @default.
- W1963992862 cites W1538891287 @default.
- W1963992862 cites W1564674105 @default.
- W1963992862 cites W1585437324 @default.
- W1963992862 cites W1883357276 @default.
- W1963992862 cites W1955736456 @default.
- W1963992862 cites W1957106 @default.
- W1963992862 cites W1967652419 @default.
- W1963992862 cites W1968144742 @default.
- W1963992862 cites W1968260936 @default.
- W1963992862 cites W1968500926 @default.
- W1963992862 cites W1969990934 @default.
- W1963992862 cites W1970977839 @default.
- W1963992862 cites W1971326215 @default.
- W1963992862 cites W1973705009 @default.
- W1963992862 cites W1974220336 @default.
- W1963992862 cites W1977093147 @default.
- W1963992862 cites W1977311786 @default.
- W1963992862 cites W1978753072 @default.
- W1963992862 cites W1979978633 @default.
- W1963992862 cites W1980406902 @default.
- W1963992862 cites W1980864403 @default.
- W1963992862 cites W1981829804 @default.
- W1963992862 cites W1983322974 @default.
- W1963992862 cites W1983653170 @default.
- W1963992862 cites W1985186312 @default.
- W1963992862 cites W1990250600 @default.
- W1963992862 cites W1997215929 @default.
- W1963992862 cites W1997538895 @default.
- W1963992862 cites W1998557118 @default.
- W1963992862 cites W1999448616 @default.
- W1963992862 cites W2004085515 @default.
- W1963992862 cites W2007133051 @default.
- W1963992862 cites W2008994613 @default.
- W1963992862 cites W2009755276 @default.
- W1963992862 cites W2010756540 @default.
- W1963992862 cites W2016459748 @default.
- W1963992862 cites W2018079705 @default.
- W1963992862 cites W2018545529 @default.
- W1963992862 cites W2022156875 @default.
- W1963992862 cites W2025313459 @default.
- W1963992862 cites W2025748388 @default.
- W1963992862 cites W2028533885 @default.
- W1963992862 cites W2035090194 @default.
- W1963992862 cites W2036565537 @default.
- W1963992862 cites W2039676069 @default.
- W1963992862 cites W2045857168 @default.
- W1963992862 cites W2047408781 @default.
- W1963992862 cites W2051531399 @default.
- W1963992862 cites W2053728895 @default.
- W1963992862 cites W2056957156 @default.
- W1963992862 cites W2057884468 @default.
- W1963992862 cites W2058177351 @default.
- W1963992862 cites W2062594120 @default.
- W1963992862 cites W2064535683 @default.
- W1963992862 cites W2070982129 @default.
- W1963992862 cites W2073597522 @default.
- W1963992862 cites W2078717028 @default.
- W1963992862 cites W2080021419 @default.
- W1963992862 cites W2080159701 @default.
- W1963992862 cites W2086425449 @default.
- W1963992862 cites W2086979720 @default.
- W1963992862 cites W2091365853 @default.
- W1963992862 cites W2096316234 @default.
- W1963992862 cites W2097843921 @default.
- W1963992862 cites W2098233979 @default.
- W1963992862 cites W2102275580 @default.
- W1963992862 cites W2102766489 @default.
- W1963992862 cites W2103420764 @default.
- W1963992862 cites W2104018866 @default.
- W1963992862 cites W2105493092 @default.
- W1963992862 cites W2107443128 @default.
- W1963992862 cites W2109950448 @default.
- W1963992862 cites W2110771206 @default.
- W1963992862 cites W2111648479 @default.
- W1963992862 cites W2119839245 @default.
- W1963992862 cites W2121052913 @default.
- W1963992862 cites W2130774572 @default.
- W1963992862 cites W2140400261 @default.
- W1963992862 cites W2142546697 @default.
- W1963992862 cites W2144114922 @default.