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- W1963996422 abstract "Progression of age-related macular degeneration (AMD), the leading cause of blindness in the elderly, was followed in a cohort of 238 individuals from a single center. Individuals with an epsilon (epsilon)2 genotype (c.526C>T of reference sequence NM_000041.2) of the apolipoprotein (APOE) gene were found to be strongly associated with disease with a significant 4.8-fold increased relative risk compared to individuals with an epsilon4 genotype (c.388T>C of reference sequence NM_000041.2) (odds ratio [OR], 4.8; 95% confidence interval [CI], 1.19-19.09) and a nearly significant three-fold increased relative risk compared to individuals with an epsilon3 genotype (reference sequence NM_000041.2) (OR, 2.8; 95% CI, 0.96-19.09). This finding was present only in females who progressed with AMD, which suggests that there may be a gender-specific role in progression of AMD in individuals with an epsilon2 allele. A gender-related factor is therefore implicated either directly or indirectly in the AMD disease process." @default.
- W1963996422 created "2016-06-24" @default.
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- W1963996422 date "2006-01-01" @default.
- W1963996422 modified "2023-10-17" @default.
- W1963996422 title "Apolipoprotein (APOE) gene is associated with progression of age-related macular degeneration (AMD)" @default.
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- W1963996422 doi "https://doi.org/10.1002/humu.20288" @default.
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