FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964001552> ?p ?o ?g. }

• W1964001552 abstract "The Ctc1-Stn1-Ten1 (CST) complex is an RPA (replication protein A)-like protein complex that binds to single-stranded (ss) DNA. It localizes at telomeres and is involved in telomere end protection in mammals and plants. It is also known to stimulate DNA polymerase α-primase in vitro. However, it is not known how CST accomplishes these functions in vivo. Here, we report the identification and characterization of Xenopus laevis CST complex (xCST). xCST showed ssDNA binding activity with moderate preference for G (guanine)-rich sequences. xStn1-immunodepleted Xenopus egg extracts supported chromosomal DNA replication in in vitro reconstituted sperm nuclei, suggesting that xCST is not a general replication factor. However, the immunodepletion or neutralization of xStn1 compromised DNA synthesis on ssDNA template. Because primed ssDNA template was replicated in xStn1-immunodepleted extracts as efficiently as in control ones, we conclude that xCST is involved in the priming step on ssDNA template. These results are consistent with the current model that CST is involved in telomeric C-strand synthesis through the regulation of DNA polymerase α-primase." @default.
• W1964001552 created "2016-06-24" @default.
• W1964001552 creator A5008325107 @default.
• W1964001552 creator A5061154995 @default.
• W1964001552 creator A5082781639 @default.
• W1964001552 creator A5086892094 @default.
• W1964001552 date "2012-01-01" @default.
• W1964001552 modified "2023-09-28" @default.
• W1964001552 title "Xenopus laevis Ctc1-Stn1-Ten1 (xCST) Protein Complex Is Involved in Priming DNA Synthesis on Single-stranded DNA Template in Xenopus Egg Extract" @default.
• W1964001552 cites W10876090 @default.
• W1964001552 cites W116768201 @default.
• W1964001552 cites W1812309617 @default.
• W1964001552 cites W1965343035 @default.
• W1964001552 cites W1965580483 @default.
• W1964001552 cites W1965730187 @default.
• W1964001552 cites W1973544851 @default.
• W1964001552 cites W1974394081 @default.
• W1964001552 cites W1980681058 @default.
• W1964001552 cites W1987643363 @default.
• W1964001552 cites W1989635874 @default.
• W1964001552 cites W1990725745 @default.
• W1964001552 cites W2003718497 @default.
• W1964001552 cites W2020038227 @default.
• W1964001552 cites W2025125299 @default.
• W1964001552 cites W2028500901 @default.
• W1964001552 cites W2029369774 @default.
• W1964001552 cites W2030923676 @default.
• W1964001552 cites W2033263385 @default.
• W1964001552 cites W2043545239 @default.
• W1964001552 cites W2043745412 @default.
• W1964001552 cites W2054886072 @default.
• W1964001552 cites W2070127489 @default.
• W1964001552 cites W2075006474 @default.
• W1964001552 cites W2114697209 @default.
• W1964001552 cites W2116463355 @default.
• W1964001552 cites W2121460534 @default.
• W1964001552 cites W2124536238 @default.
• W1964001552 cites W2125733067 @default.
• W1964001552 cites W2127972823 @default.
• W1964001552 cites W2128322002 @default.
• W1964001552 cites W2133685006 @default.
• W1964001552 cites W2156057350 @default.
• W1964001552 cites W2160001213 @default.
• W1964001552 cites W2165321825 @default.
• W1964001552 cites W2167247319 @default.
• W1964001552 cites W2171775098 @default.
• W1964001552 doi "https://doi.org/10.1074/jbc.m111.263723" @default.
• W1964001552 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3249116" @default.
• W1964001552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22086929" @default.
• W1964001552 hasPublicationYear "2012" @default.
• W1964001552 type Work @default.
• W1964001552 sameAs 1964001552 @default.
• W1964001552 citedByCount "65" @default.
• W1964001552 countsByYear W19640015522012 @default.
• W1964001552 countsByYear W19640015522013 @default.
• W1964001552 countsByYear W19640015522014 @default.
• W1964001552 countsByYear W19640015522015 @default.
• W1964001552 countsByYear W19640015522016 @default.
• W1964001552 countsByYear W19640015522017 @default.
• W1964001552 countsByYear W19640015522018 @default.
• W1964001552 countsByYear W19640015522019 @default.
• W1964001552 countsByYear W19640015522020 @default.
• W1964001552 countsByYear W19640015522021 @default.
• W1964001552 countsByYear W19640015522022 @default.
• W1964001552 countsByYear W19640015522023 @default.
• W1964001552 crossrefType "journal-article" @default.
• W1964001552 hasAuthorship W1964001552A5008325107 @default.
• W1964001552 hasAuthorship W1964001552A5061154995 @default.
• W1964001552 hasAuthorship W1964001552A5082781639 @default.
• W1964001552 hasAuthorship W1964001552A5086892094 @default.
• W1964001552 hasBestOaLocation W19640015521 @default.
• W1964001552 hasConcept C104317684 @default.
• W1964001552 hasConcept C113271649 @default.
• W1964001552 hasConcept C149187182 @default.
• W1964001552 hasConcept C153911025 @default.
• W1964001552 hasConcept C156719811 @default.
• W1964001552 hasConcept C188036394 @default.
• W1964001552 hasConcept C194830204 @default.
• W1964001552 hasConcept C2756471 @default.
• W1964001552 hasConcept C2779535977 @default.
• W1964001552 hasConcept C31254050 @default.
• W1964001552 hasConcept C54355233 @default.
• W1964001552 hasConcept C552990157 @default.
• W1964001552 hasConcept C67705224 @default.
• W1964001552 hasConcept C73573662 @default.
• W1964001552 hasConcept C82381507 @default.
• W1964001552 hasConcept C86339819 @default.
• W1964001552 hasConcept C86803240 @default.
• W1964001552 hasConcept C88354546 @default.
• W1964001552 hasConcept C94966510 @default.
• W1964001552 hasConcept C95444343 @default.
• W1964001552 hasConcept C98086919 @default.
• W1964001552 hasConceptScore W1964001552C104317684 @default.
• W1964001552 hasConceptScore W1964001552C113271649 @default.
• W1964001552 hasConceptScore W1964001552C149187182 @default.
• W1964001552 hasConceptScore W1964001552C153911025 @default.
• W1964001552 hasConceptScore W1964001552C156719811 @default.
• W1964001552 hasConceptScore W1964001552C188036394 @default.
• W1964001552 hasConceptScore W1964001552C194830204 @default.
• W1964001552 hasConceptScore W1964001552C2756471 @default.

• next