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- W1964001819 abstract "Transgenic overexpression of Fli-1 in normal mice leads to SLE-like disease and increased expression was reported in SLE-affected human and murine lymphocytes. Reducing Fli-1 expression in MRL/lpr mice decreased antibody production, proteinuria, renal pathology, and mortality. Compared to those with wild-type expression of Fli-1, we report here that proliferative responses of Fli-1-deficient naïve B cells to several mitogens were reduced in lupus-prone and control mice. Expression of mitogen receptors, including BCR, TLR4, and TLR9, was not significantly impacted in Fli-1-deficient naïve B cells. IL12a transcripts were upregulated and NFAT transcripts were downregulated in Fli-1-deficient MRL/lpr B cells. These results demonstrate that Fli-1 deficiency affects B cell proliferative responses to mitogens, independent of BCR and TLR expression. IL12a and NFAT, known to influence proliferation, were identified as potential mediators of this effect. This may be a mechanism by which overexpression of Fli-1 contributes to B cell hyperactivity and subsequent SLE pathogenesis." @default.
- W1964001819 created "2016-06-24" @default.
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- W1964001819 date "2008-10-01" @default.
- W1964001819 modified "2023-10-16" @default.
- W1964001819 title "A role for Fli-1 in B cell proliferation: Implications for SLE pathogenesis" @default.
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- W1964001819 doi "https://doi.org/10.1016/j.clim.2008.05.010" @default.
- W1964001819 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2562591" @default.
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