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• W1964003463 startingPage "383" @default.
• W1964003463 abstract "During meiotic reinitiation of the mouse oocyte, entry into M-phase is regulated by changes of protein phosphorylation and by the stimulation of selective mRNA translation following the nuclear membrane dissolution. Our results reveal that M-phase kinases (MAP kinase and histone H1 kinase) are being activated together with S6 kinase and with the phosphorylation of eIF4E, the cap-binding subunit of the initiation factor eIF-4F. In order to test which signaling pathway(s) is(are) involved, okadaic acid and cycloheximide have been used as tools for differentially modulating MAP and histone H1 kinase activities. A role for MAP kinases in the phosphorylation of eIF4E and the activation of S6 kinase is suggested. The possible implication of p90rsk and/or of p70s6k in the overall increase in S6 kinase activity has been examined. p70s6k does not appear to be involved since phosphorylated forms are found in prophase and maturing oocytes. In contrast, p90rsk is phosphorylated and activated in maturing oocytes. p90rSk phosphorylation correlates with the activation of S6 kinase. These results suggest that the overall increase of S6 kinase activity is mostly due to p90rsk activation. The roles of eIF4E phosphorylation and S6 kinase activation in the physiological induction of M-phase and in the okadaic acid-induced premature mitotic events are discussed." @default.
• W1964003463 created "2016-06-24" @default.
• W1964003463 creator A5006067126 @default.
• W1964003463 creator A5028869605 @default.
• W1964003463 date "1997-03-01" @default.
• W1964003463 modified "2023-10-18" @default.
• W1964003463 title "Ribosomal S6 kinase p90 ^rsk and mRNA cap‐binding protein eIF4E phosphorylations correlate with MAP kinase activation during meiotic reinitiation of mouse oocytes" @default.
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• W1964003463 doi "https://doi.org/10.1002/(sici)1098-2795(199703)46:3<383::aid-mrd18>3.0.co;2-#" @default.
• W1964003463 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9041142" @default.
• W1964003463 hasPublicationYear "1997" @default.
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