FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964009045> ?p ?o ?g. }

• W1964009045 endingPage "226" @default.
• W1964009045 startingPage "217" @default.
• W1964009045 abstract "Spontaneous depolarizations around the core are a consistent feature of focal cerebral ischemia, but the associated regional hemodynamic changes are heterogeneous. We determined how the features of depolarizations relate to subsequent cerebral blood flow (CBF) changes in global forebrain ischemia. Forebrain ischemia was produced in halothane-anesthetized rats (n = 13) by common carotid artery occlusion and hypovolemic hypotension. Mean arterial blood pressure (MABP) was monitored via a femoral catheter. Specific illuminations allowed the capture of image sequences through a cranial window to visualize: changes in membrane potential (voltage-sensitive dye method); CBF (laser speckle contrast imaging); cerebral blood volume (intrinsic optical signal, IOS at 540–550 nm); and hemoglobin deoxygenation (IOS at 620–640 nm). A depolarization occurred (n = 9) when CBF fell below 43.4 ± 5% of control (41 ± 4 mmHg MABP), and propagated with a distinct wave front at a rate of 2.8 mm/min. Depolarizations were either persistent (n = 4), intermediate (n = 3) or short, transient depolarization (n = 2). Persistent and intermediate depolarizations were associated with sustained hypoperfusion (−11.7 ± 5.1%) and transient hypoperfusion (−17.4 ± 5.2, relative to CBF before depolarization). Short, transient depolarizations did not generate clear CBF responses. Depolarizations during incomplete global ischemia occurred at the lower limit of CBF autoregulation, propagated similar to spreading depolarization (SD), and the hemodynamic responses indicated inverse neurovascular coupling. Similar to SDs associated with focal stroke, the propagating event can be persistent or transient." @default.
• W1964009045 created "2016-06-24" @default.
• W1964009045 creator A5027805935 @default.
• W1964009045 creator A5035263421 @default.
• W1964009045 creator A5066357633 @default.
• W1964009045 creator A5069128129 @default.
• W1964009045 date "2014-02-01" @default.
• W1964009045 modified "2023-09-26" @default.
• W1964009045 title "Ischemia-induced depolarizations and associated hemodynamic responses in incomplete global forebrain ischemia in rats" @default.
• W1964009045 cites W1841463848 @default.
• W1964009045 cites W1965983192 @default.
• W1964009045 cites W1971025276 @default.
• W1964009045 cites W1976084898 @default.
• W1964009045 cites W1984070458 @default.
• W1964009045 cites W1984662157 @default.
• W1964009045 cites W1992294955 @default.
• W1964009045 cites W1994137439 @default.
• W1964009045 cites W1997032556 @default.
• W1964009045 cites W2008437322 @default.
• W1964009045 cites W2009185298 @default.
• W1964009045 cites W2019475363 @default.
• W1964009045 cites W2019639662 @default.
• W1964009045 cites W2021580299 @default.
• W1964009045 cites W2029642457 @default.
• W1964009045 cites W2043394084 @default.
• W1964009045 cites W2045588627 @default.
• W1964009045 cites W2060215608 @default.
• W1964009045 cites W2062219686 @default.
• W1964009045 cites W2072168198 @default.
• W1964009045 cites W2075963191 @default.
• W1964009045 cites W2077484357 @default.
• W1964009045 cites W2083031870 @default.
• W1964009045 cites W2090718053 @default.
• W1964009045 cites W2104522926 @default.
• W1964009045 cites W2110784169 @default.
• W1964009045 cites W2111769069 @default.
• W1964009045 cites W2116851614 @default.
• W1964009045 cites W2117340226 @default.
• W1964009045 cites W2118401165 @default.
• W1964009045 cites W2118743338 @default.
• W1964009045 cites W2129867971 @default.
• W1964009045 cites W2139905653 @default.
• W1964009045 cites W2145252529 @default.
• W1964009045 cites W2162848053 @default.
• W1964009045 cites W2223115644 @default.
• W1964009045 doi "https://doi.org/10.1016/j.neuroscience.2013.12.032" @default.
• W1964009045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24365459" @default.
• W1964009045 hasPublicationYear "2014" @default.
• W1964009045 type Work @default.
• W1964009045 sameAs 1964009045 @default.
• W1964009045 citedByCount "37" @default.
• W1964009045 countsByYear W19640090452014 @default.
• W1964009045 countsByYear W19640090452015 @default.
• W1964009045 countsByYear W19640090452016 @default.
• W1964009045 countsByYear W19640090452017 @default.
• W1964009045 countsByYear W19640090452018 @default.
• W1964009045 countsByYear W19640090452019 @default.
• W1964009045 countsByYear W19640090452020 @default.
• W1964009045 countsByYear W19640090452021 @default.
• W1964009045 countsByYear W19640090452022 @default.
• W1964009045 countsByYear W19640090452023 @default.
• W1964009045 crossrefType "journal-article" @default.
• W1964009045 hasAuthorship W1964009045A5027805935 @default.
• W1964009045 hasAuthorship W1964009045A5035263421 @default.
• W1964009045 hasAuthorship W1964009045A5066357633 @default.
• W1964009045 hasAuthorship W1964009045A5069128129 @default.
• W1964009045 hasConcept C126322002 @default.
• W1964009045 hasConcept C157767197 @default.
• W1964009045 hasConcept C164705383 @default.
• W1964009045 hasConcept C178853913 @default.
• W1964009045 hasConcept C4141045 @default.
• W1964009045 hasConcept C42219234 @default.
• W1964009045 hasConcept C541997718 @default.
• W1964009045 hasConcept C71924100 @default.
• W1964009045 hasConceptScore W1964009045C126322002 @default.
• W1964009045 hasConceptScore W1964009045C157767197 @default.
• W1964009045 hasConceptScore W1964009045C164705383 @default.
• W1964009045 hasConceptScore W1964009045C178853913 @default.
• W1964009045 hasConceptScore W1964009045C4141045 @default.
• W1964009045 hasConceptScore W1964009045C42219234 @default.
• W1964009045 hasConceptScore W1964009045C541997718 @default.
• W1964009045 hasConceptScore W1964009045C71924100 @default.
• W1964009045 hasFunder F4320321994 @default.
• W1964009045 hasLocation W19640090451 @default.
• W1964009045 hasLocation W19640090452 @default.
• W1964009045 hasOpenAccess W1964009045 @default.
• W1964009045 hasPrimaryLocation W19640090451 @default.
• W1964009045 hasRelatedWork W1971983346 @default.
• W1964009045 hasRelatedWork W2067363300 @default.
• W1964009045 hasRelatedWork W2095575380 @default.
• W1964009045 hasRelatedWork W2131873822 @default.
• W1964009045 hasRelatedWork W2373402090 @default.
• W1964009045 hasRelatedWork W2392249173 @default.
• W1964009045 hasRelatedWork W2394372752 @default.
• W1964009045 hasRelatedWork W2410112552 @default.
• W1964009045 hasRelatedWork W4293426766 @default.
• W1964009045 hasRelatedWork W4382808714 @default.
• W1964009045 hasVolume "260" @default.

• next