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- W1964015861 abstract "The isoprenoid biosynthetic capacity of digenetic trematodes was investigated by following the fate of [14C]mevalonic acid incorporated by Schistosoma mansoni during maintenance in axenic culture. Isoprenoid compounds were analyzed by thin-layer chromatography and high-performance liquid chromatography. Of the nonsaponifiable lipid classes, radioactivity was recovered in the dolichols, ubiquinones and in the short-chain isoprenoid alcohols. The latter group of lipids included geraniol, farnesol, geranylgeraniol and a compound tentatively identified as 2,3-dihydrogeranylgeraniol. Radioactivity derived from [14C]mevalonate was also incorporated into the saponifiable lipids, with 2,3-dihydrogeranylgeranoic acid accompanied by much less geranylgeranoic acid being detected in the triacylglycerol-containing fraction. Similarly, geranylgeraniol and the dihydro derivative were also detected as esters, presumably with fatty acids. The possible significance of the results is discussed." @default.
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- W1964015861 date "1993-10-01" @default.
- W1964015861 modified "2023-09-25" @default.
- W1964015861 title "Biosynthesis of isoprenoid compounds in Schistosoma mansoni" @default.
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- W1964015861 doi "https://doi.org/10.1016/0166-6851(93)90073-7" @default.
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