FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964015890> ?p ?o ?g. }

• W1964015890 endingPage "8" @default.
• W1964015890 startingPage "1" @default.
• W1964015890 abstract "Recurrent Clostridium difficile infection represents a burdensome clinical issue whose epidemiology is increasing worldwide. The pathogenesis is not yet completely known. Recent observations suggest that the alteration of the intestinal microbiota and impaired innate immunity may play a leading role in the development of recurrent infection. Various factors can cause dysbiosis. The causes most involved in the process are antibiotics, NSAIDs, acid suppressing therapies, and age. Gut microbiota impairment can favor Clostridium difficile infection through several mechanisms, such as the alteration of fermentative metabolism (especially SCFAs), the alteration of bile acid metabolism, and the imbalance of antimicrobial substances production. These factors alter the intestinal homeostasis promoting the development of an ecological niche for Clostridium difficile and of the modulation of immune response. Moreover, the intestinal dysbiosis can promote a proinflammatory environment, whereas Clostridium difficile itself modulates the innate immunity through both toxin-dependent and toxin-independent mechanisms. In this narrative review, we discuss how the intestinal microbiota modifications and the modulation of innate immune response can lead to and exacerbate Clostridium difficile infection." @default.
• W1964015890 created "2016-06-24" @default.
• W1964015890 creator A5017513473 @default.
• W1964015890 creator A5051347954 @default.
• W1964015890 creator A5054710123 @default.
• W1964015890 creator A5063148714 @default.
• W1964015890 creator A5078126497 @default.
• W1964015890 creator A5085399427 @default.
• W1964015890 date "2014-01-01" @default.
• W1964015890 modified "2023-10-04" @default.
• W1964015890 title "Role of Microbiota and Innate Immunity in Recurrent<i>Clostridium difficile</i>Infection" @default.
• W1964015890 cites W1705744822 @default.
• W1964015890 cites W1880099864 @default.
• W1964015890 cites W1916481354 @default.
• W1964015890 cites W1922170860 @default.
• W1964015890 cites W1965385111 @default.
• W1964015890 cites W1965985248 @default.
• W1964015890 cites W1970866779 @default.
• W1964015890 cites W1970936978 @default.
• W1964015890 cites W1975176103 @default.
• W1964015890 cites W1982469681 @default.
• W1964015890 cites W1987833041 @default.
• W1964015890 cites W2000898646 @default.
• W1964015890 cites W2005258869 @default.
• W1964015890 cites W2020510938 @default.
• W1964015890 cites W2020867722 @default.
• W1964015890 cites W2022771107 @default.
• W1964015890 cites W2027925091 @default.
• W1964015890 cites W2032605132 @default.
• W1964015890 cites W2034025647 @default.
• W1964015890 cites W2034157397 @default.
• W1964015890 cites W2034730227 @default.
• W1964015890 cites W2047667187 @default.
• W1964015890 cites W2054164832 @default.
• W1964015890 cites W2060392431 @default.
• W1964015890 cites W2064654077 @default.
• W1964015890 cites W2069800046 @default.
• W1964015890 cites W2069812362 @default.
• W1964015890 cites W2071273298 @default.
• W1964015890 cites W2076986757 @default.
• W1964015890 cites W2083033324 @default.
• W1964015890 cites W2088186083 @default.
• W1964015890 cites W2094041617 @default.
• W1964015890 cites W2096095879 @default.
• W1964015890 cites W2096436144 @default.
• W1964015890 cites W2097875133 @default.
• W1964015890 cites W2099119185 @default.
• W1964015890 cites W2102695942 @default.
• W1964015890 cites W2105274559 @default.
• W1964015890 cites W2106475692 @default.
• W1964015890 cites W2107600264 @default.
• W1964015890 cites W2108213856 @default.
• W1964015890 cites W2108474241 @default.
• W1964015890 cites W2109457794 @default.
• W1964015890 cites W2110235509 @default.
• W1964015890 cites W2110389012 @default.
• W1964015890 cites W2112737606 @default.
• W1964015890 cites W2112738213 @default.
• W1964015890 cites W2114552485 @default.
• W1964015890 cites W2115717127 @default.
• W1964015890 cites W2117560359 @default.
• W1964015890 cites W2119628653 @default.
• W1964015890 cites W2127424257 @default.
• W1964015890 cites W2129724696 @default.
• W1964015890 cites W2134442057 @default.
• W1964015890 cites W2138179648 @default.
• W1964015890 cites W2139566520 @default.
• W1964015890 cites W2139607253 @default.
• W1964015890 cites W2141125135 @default.
• W1964015890 cites W2141368172 @default.
• W1964015890 cites W2142519377 @default.
• W1964015890 cites W2142559837 @default.
• W1964015890 cites W2146624345 @default.
• W1964015890 cites W2148223907 @default.
• W1964015890 cites W2152417392 @default.
• W1964015890 cites W2155378208 @default.
• W1964015890 cites W2158871837 @default.
• W1964015890 cites W2164526495 @default.
• W1964015890 cites W2164640614 @default.
• W1964015890 cites W2166660180 @default.
• W1964015890 cites W2166709849 @default.
• W1964015890 cites W2167398352 @default.
• W1964015890 cites W2169330513 @default.
• W1964015890 cites W2169731572 @default.
• W1964015890 cites W2268361357 @default.
• W1964015890 cites W4313347687 @default.
• W1964015890 doi "https://doi.org/10.1155/2014/462740" @default.
• W1964015890 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4068057" @default.
• W1964015890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24995345" @default.
• W1964015890 hasPublicationYear "2014" @default.
• W1964015890 type Work @default.
• W1964015890 sameAs 1964015890 @default.
• W1964015890 citedByCount "43" @default.
• W1964015890 countsByYear W19640158902015 @default.
• W1964015890 countsByYear W19640158902016 @default.
• W1964015890 countsByYear W19640158902017 @default.
• W1964015890 countsByYear W19640158902018 @default.
• W1964015890 countsByYear W19640158902019 @default.

• next