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• W1964025326 abstract "Experimental autoimmune myocarditis (EAM) can be induced in the Lewis rat by cardiac myosin or its cryptic S2-16 peptide epitope (amino acids 1052 to 1076). To investigate cellular mechanisms and the role of antigen-presenting cells in regulation of myocarditis, we induced protection against EAM in Lewis rats by administration of S2-16 peptide in incomplete Freund's adjuvant (IFA). Protection to EAM was associated with activation of S2-16-reactive splenocytes secreting high levels of interleukin (IL)-10 and reduced levels of interferon-gamma and IL-2. Adoptive transfer of S2-16:IFA-induced splenocytes producing IL-10 suppressed myocarditis induction in syngeneic recipients, suggesting their regulatory cell nature. However, exposure of S2-16:IFA-induced cells to inflammatory cytokine IL-12 converted them to Th1 effectors that transferred EAM. Differentiated function of S2-16-reactive T cells in protected rats resulted from increased IL-10 production by dendritic cells (DCs). Purified DCs from S2-16:IFA-treated rats promoted S2-16-reactive CD4+ T cells to produce increased IL-10 and reduced interferon-gamma. In addition, adoptive transfer of IL-10-producing DCs from S2-16:IFA-treated rats also induced protection to EAM in recipient rats. These studies demonstrated DCs and key cytokines, such as IL-10 and IL-12, regulated the fate of T cells in myocarditis development in the Lewis rat." @default.
• W1964025326 created "2016-06-24" @default.
• W1964025326 creator A5017193282 @default.
• W1964025326 creator A5020907549 @default.
• W1964025326 creator A5024828248 @default.
• W1964025326 creator A5068218416 @default.
• W1964025326 creator A5078534673 @default.
• W1964025326 date "2005-07-01" @default.
• W1964025326 modified "2023-10-18" @default.
• W1964025326 title "Protection against Experimental Autoimmune Myocarditis Is Mediated by Interleukin-10-Producing T Cells that Are Controlled by Dendritic Cells" @default.
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• W1964025326 doi "https://doi.org/10.1016/s0002-9440(10)62948-3" @default.
• W1964025326 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1603447" @default.
• W1964025326 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15972947" @default.
• W1964025326 hasPublicationYear "2005" @default.

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