FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964032714> ?p ?o ?g. }

• W1964032714 endingPage "2529" @default.
• W1964032714 startingPage "2521" @default.
• W1964032714 abstract "Abstract We have previously reported that innervation-dependent basal contractile activity regulates in an inverse manner the expression of GLUT1 and GLUT4 glucose transporters in skeletal muscle. Based on the facts that muscle innervation decreases and muscle denervation increases cAMP levels, we investigated whether cAMP might mediate the effects of innervation/denervation on glucose transporter expression. Treatment of L6E9 myotubes with 8-bromo-cAMP, forskolin, or monobutyryl-8-bromo-cAMP led to a marked decrease in GLUT4 protein levels; 8-bromo-cAMP also diminished GLUT4 messenger RNA (mRNA), suggesting pretranslational repression. In contrast, L6E9 myoblasts and myotubes responded to 8-bromo-cAMP or forskolin by increasing the cell content of GLUT1 protein. Induction of GLUT1 protein was a consequence of the activation of different mechanisms in myoblast and myotube cells; whereas 8-bromo-cAMP treatment caused a substantial increase in GLUT1 mRNA in myoblasts, no change in GLUT1 mRNA was detected in myotubes. The increase in GLUT1 mRNA in L6E9 myoblasts induced by 8-bromo-cAMP was the result of transcriptional activation, as concluded from transfection analysis of 2.1 kilobases of the rat GLUT1 gene promoter fused to the bacterial chloramphenicol acetyltransferase gene. Furthermore, the stimulatory effect of 8-bromo-cAMP on the transcriptional activity of the GLUT1 promoter required a 33-bp sequence lying 5′ upstream of the transcription start site. In all, cAMP inversely regulates GLUT4 and GLUT1 glucose transporter expression in muscle cells. Furthermore, our results suggest that down-regulation of GLUT4 expression and up-regulation of GLUT1 expression in muscle associated with denervation are partly attributable to cAMP." @default.
• W1964032714 created "2016-06-24" @default.
• W1964032714 creator A5020011096 @default.
• W1964032714 creator A5032060997 @default.
• W1964032714 creator A5040582301 @default.
• W1964032714 creator A5041296228 @default.
• W1964032714 creator A5041712131 @default.
• W1964032714 creator A5059581003 @default.
• W1964032714 creator A5079234090 @default.
• W1964032714 date "1997-06-01" @default.
• W1964032714 modified "2023-10-14" @default.
• W1964032714 title "Cyclic Adenosine 3′,5′-Monophosphate Regulates GLUT4 and GLUT1 Glucose Transporter Expression and Stimulates Transcriptional Activity of the GLUT1 Promoter in Muscle Cells*" @default.
• W1964032714 cites W146700098 @default.
• W1964032714 cites W1483367645 @default.
• W1964032714 cites W1490006539 @default.
• W1964032714 cites W1498131153 @default.
• W1964032714 cites W1501851749 @default.
• W1964032714 cites W1508736526 @default.
• W1964032714 cites W1509104855 @default.
• W1964032714 cites W1517205951 @default.
• W1964032714 cites W1533465487 @default.
• W1964032714 cites W1543750783 @default.
• W1964032714 cites W1552039250 @default.
• W1964032714 cites W1564556915 @default.
• W1964032714 cites W1579749290 @default.
• W1964032714 cites W1586627930 @default.
• W1964032714 cites W1589137921 @default.
• W1964032714 cites W1598551221 @default.
• W1964032714 cites W1602403912 @default.
• W1964032714 cites W1645918562 @default.
• W1964032714 cites W1788773694 @default.
• W1964032714 cites W1871951699 @default.
• W1964032714 cites W1912057247 @default.
• W1964032714 cites W1965372133 @default.
• W1964032714 cites W1965482152 @default.
• W1964032714 cites W1971060217 @default.
• W1964032714 cites W1974104252 @default.
• W1964032714 cites W1975572108 @default.
• W1964032714 cites W1999464418 @default.
• W1964032714 cites W2005854204 @default.
• W1964032714 cites W2011413367 @default.
• W1964032714 cites W2011834894 @default.
• W1964032714 cites W2019457878 @default.
• W1964032714 cites W2020811802 @default.
• W1964032714 cites W2021464909 @default.
• W1964032714 cites W2025592833 @default.
• W1964032714 cites W2028124917 @default.
• W1964032714 cites W2028627182 @default.
• W1964032714 cites W2043535342 @default.
• W1964032714 cites W2052202442 @default.
• W1964032714 cites W2056701097 @default.
• W1964032714 cites W2066928379 @default.
• W1964032714 cites W2069300649 @default.
• W1964032714 cites W2074060029 @default.
• W1964032714 cites W2087015690 @default.
• W1964032714 cites W2092618241 @default.
• W1964032714 cites W2100837269 @default.
• W1964032714 cites W2105554313 @default.
• W1964032714 cites W2112526115 @default.
• W1964032714 cites W2123701599 @default.
• W1964032714 cites W2142224189 @default.
• W1964032714 cites W2144206181 @default.
• W1964032714 cites W2155321065 @default.
• W1964032714 cites W2169401893 @default.
• W1964032714 cites W2397081417 @default.
• W1964032714 cites W4293247451 @default.
• W1964032714 cites W4294216491 @default.
• W1964032714 doi "https://doi.org/10.1210/endo.138.6.5217" @default.
• W1964032714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9165044" @default.
• W1964032714 hasPublicationYear "1997" @default.
• W1964032714 type Work @default.
• W1964032714 sameAs 1964032714 @default.
• W1964032714 citedByCount "29" @default.
• W1964032714 countsByYear W19640327142013 @default.
• W1964032714 countsByYear W19640327142015 @default.
• W1964032714 countsByYear W19640327142016 @default.
• W1964032714 countsByYear W19640327142017 @default.
• W1964032714 countsByYear W19640327142019 @default.
• W1964032714 crossrefType "journal-article" @default.
• W1964032714 hasAuthorship W1964032714A5020011096 @default.
• W1964032714 hasAuthorship W1964032714A5032060997 @default.
• W1964032714 hasAuthorship W1964032714A5040582301 @default.
• W1964032714 hasAuthorship W1964032714A5041296228 @default.
• W1964032714 hasAuthorship W1964032714A5041712131 @default.
• W1964032714 hasAuthorship W1964032714A5059581003 @default.
• W1964032714 hasAuthorship W1964032714A5079234090 @default.
• W1964032714 hasBestOaLocation W19640327141 @default.
• W1964032714 hasConcept C126322002 @default.
• W1964032714 hasConcept C134018914 @default.
• W1964032714 hasConcept C161573976 @default.
• W1964032714 hasConcept C207200792 @default.
• W1964032714 hasConcept C24998067 @default.
• W1964032714 hasConcept C2776188179 @default.
• W1964032714 hasConcept C2777952866 @default.
• W1964032714 hasConcept C2779276759 @default.
• W1964032714 hasConcept C2779306644 @default.
• W1964032714 hasConcept C2908666080 @default.
• W1964032714 hasConcept C3763915 @default.

• next