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- W1964036735 abstract "RATIONALE: Both exercise and inhaled mannitol are indirect stimuli for bronchial constriction. This study aimed to verify whether responsiveness to inhaled mannitol and the refractoriness to repeated mannitol challenges can reflect the exercise-induced bronchoconstriction (EIB) and the refractoriness to repeated exercise challenges. METHOD: Forty-one subjects with a history of EIB underwent each pair of exercise challenges or mannitol inhalations on a separate day in random order. The percentage fall in forced expiratory volume in 1 second (delta FEV1%) after each challenge test and the refractoriness index (reduction in delta FEV1% of the consecutive challenge compared with preceding one) in each pair were calculated and compared. RESULTS: There was a good relationship between delta FEV1% of 1st exercise challenge and the log-transformed value of provocative dose of inhaled mannitol causing a 15% fall in FEV1 (logPD15) in the first challenge with inhaled mannitol (r =-0.425, P =0.006). The refractoriness indices of repeated exercise challenges correlated with those of repeated mannitol inhalations. (r =0.378, P =0.015). CONCLUSION: Mannitol challenge test may be a sensitive tool to identify exercise-induced bronchoconstriction. The refractoriness to repeated mannitol challenges may be a predictive marker for the refractoriness to repeated exercise challenges. These findings suggest a close relationship between the exercise challenge and the mannitol inhalation in children with suspected EIB." @default.
- W1964036735 created "2016-06-24" @default.
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- W1964036735 date "2011-02-01" @default.
- W1964036735 modified "2023-09-27" @default.
- W1964036735 title "Mannitol Challenge Test to Identify Exercise-induced Bronchoconstriction and Refractoriness" @default.
- W1964036735 doi "https://doi.org/10.1016/j.jaci.2010.12.036" @default.
- W1964036735 hasPublicationYear "2011" @default.
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