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• W1964037649 startingPage "593" @default.
• W1964037649 abstract "Many intracellular pathogens survive in vacuolar niches composed of host-derived membranes modified extensively by pathogen proteins and lipids. Although intracellular lifestyles offer protection from humoral immune responses, vacuole-bound pathogens nevertheless face powerful intracellular innate immune surveillance pathways that can trigger fusion with lysosomes, autophagy, and host cell death. Strategies used by vacuole-bound pathogens to invade and establish a replicative vacuole are well described, but how the integrity and stability of these parasitic vacuoles are maintained is poorly understood. Here, we identify potential mechanisms of pathogenic vacuole maintenance and the consequences of vacuole disruption by highlighting select bacterial and protozoan parasites." @default.
• W1964037649 created "2016-06-24" @default.
• W1964037649 creator A5021498852 @default.
• W1964037649 creator A5040043604 @default.
• W1964037649 date "2009-06-01" @default.
• W1964037649 modified "2023-10-02" @default.
• W1964037649 title "Leading a Sheltered Life: Intracellular Pathogens and Maintenance of Vacuolar Compartments" @default.
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