Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964037688> ?p ?o ?g. }
- W1964037688 endingPage "851" @default.
- W1964037688 startingPage "839" @default.
- W1964037688 abstract "Mathematical modeling is required for understanding the complex behavior of large signal transduction networks. Previous attempts to model signal transduction pathways were often limited to small systems or based on qualitative data only. Here, we developed a mathematical modeling framework for understanding the complex signaling behavior of CD95(APO-1/Fas)-mediated apoptosis. Defects in the regulation of apoptosis result in serious diseases such as cancer, autoimmunity, and neurodegeneration. During the last decade many of the molecular mechanisms of apoptosis signaling have been examined and elucidated. A systemic understanding of apoptosis is, however, still missing. To address the complexity of apoptotic signaling we subdivided this system into subsystems of different information qualities. A new approach for sensitivity analysis within the mathematical model was key for the identification of critical system parameters and two essential system properties: modularity and robustness. Our model describes the regulation of apoptosis on a systems level and resolves the important question of a threshold mechanism for the regulation of apoptosis." @default.
- W1964037688 created "2016-06-24" @default.
- W1964037688 creator A5011844678 @default.
- W1964037688 creator A5040005604 @default.
- W1964037688 creator A5044191947 @default.
- W1964037688 creator A5052367772 @default.
- W1964037688 creator A5054417011 @default.
- W1964037688 creator A5068388891 @default.
- W1964037688 creator A5085420803 @default.
- W1964037688 creator A5088017596 @default.
- W1964037688 date "2004-09-13" @default.
- W1964037688 modified "2023-10-16" @default.
- W1964037688 title "Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis" @default.
- W1964037688 cites W1492587973 @default.
- W1964037688 cites W1507812324 @default.
- W1964037688 cites W1637936532 @default.
- W1964037688 cites W1642763135 @default.
- W1964037688 cites W1964287788 @default.
- W1964037688 cites W1967894078 @default.
- W1964037688 cites W1978486653 @default.
- W1964037688 cites W1982258483 @default.
- W1964037688 cites W1993327789 @default.
- W1964037688 cites W1994656497 @default.
- W1964037688 cites W2001620484 @default.
- W1964037688 cites W2007006124 @default.
- W1964037688 cites W2029311647 @default.
- W1964037688 cites W2036618934 @default.
- W1964037688 cites W2041042514 @default.
- W1964037688 cites W2044824027 @default.
- W1964037688 cites W2048711079 @default.
- W1964037688 cites W2049312704 @default.
- W1964037688 cites W2061497413 @default.
- W1964037688 cites W2068602646 @default.
- W1964037688 cites W2069242926 @default.
- W1964037688 cites W2074584594 @default.
- W1964037688 cites W2075161553 @default.
- W1964037688 cites W2084607024 @default.
- W1964037688 cites W2094599199 @default.
- W1964037688 cites W2133667940 @default.
- W1964037688 cites W2134800568 @default.
- W1964037688 cites W2143894094 @default.
- W1964037688 cites W2145626047 @default.
- W1964037688 cites W2167157054 @default.
- W1964037688 cites W2168639189 @default.
- W1964037688 cites W2168655003 @default.
- W1964037688 doi "https://doi.org/10.1083/jcb.200404158" @default.
- W1964037688 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2172102" @default.
- W1964037688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15364960" @default.
- W1964037688 hasPublicationYear "2004" @default.
- W1964037688 type Work @default.
- W1964037688 sameAs 1964037688 @default.
- W1964037688 citedByCount "304" @default.
- W1964037688 countsByYear W19640376882012 @default.
- W1964037688 countsByYear W19640376882013 @default.
- W1964037688 countsByYear W19640376882014 @default.
- W1964037688 countsByYear W19640376882015 @default.
- W1964037688 countsByYear W19640376882016 @default.
- W1964037688 countsByYear W19640376882017 @default.
- W1964037688 countsByYear W19640376882018 @default.
- W1964037688 countsByYear W19640376882019 @default.
- W1964037688 countsByYear W19640376882020 @default.
- W1964037688 countsByYear W19640376882021 @default.
- W1964037688 countsByYear W19640376882022 @default.
- W1964037688 countsByYear W19640376882023 @default.
- W1964037688 crossrefType "journal-article" @default.
- W1964037688 hasAuthorship W1964037688A5011844678 @default.
- W1964037688 hasAuthorship W1964037688A5040005604 @default.
- W1964037688 hasAuthorship W1964037688A5044191947 @default.
- W1964037688 hasAuthorship W1964037688A5052367772 @default.
- W1964037688 hasAuthorship W1964037688A5054417011 @default.
- W1964037688 hasAuthorship W1964037688A5068388891 @default.
- W1964037688 hasAuthorship W1964037688A5085420803 @default.
- W1964037688 hasAuthorship W1964037688A5088017596 @default.
- W1964037688 hasBestOaLocation W19640376881 @default.
- W1964037688 hasConcept C104317684 @default.
- W1964037688 hasConcept C121332964 @default.
- W1964037688 hasConcept C142724271 @default.
- W1964037688 hasConcept C152662350 @default.
- W1964037688 hasConcept C169760540 @default.
- W1964037688 hasConcept C190283241 @default.
- W1964037688 hasConcept C2776925932 @default.
- W1964037688 hasConcept C2779134260 @default.
- W1964037688 hasConcept C3031857 @default.
- W1964037688 hasConcept C31573885 @default.
- W1964037688 hasConcept C54355233 @default.
- W1964037688 hasConcept C62478195 @default.
- W1964037688 hasConcept C62520636 @default.
- W1964037688 hasConcept C63479239 @default.
- W1964037688 hasConcept C70721500 @default.
- W1964037688 hasConcept C71924100 @default.
- W1964037688 hasConcept C86803240 @default.
- W1964037688 hasConcept C89611455 @default.
- W1964037688 hasConcept C95444343 @default.
- W1964037688 hasConceptScore W1964037688C104317684 @default.
- W1964037688 hasConceptScore W1964037688C121332964 @default.
- W1964037688 hasConceptScore W1964037688C142724271 @default.
- W1964037688 hasConceptScore W1964037688C152662350 @default.
- W1964037688 hasConceptScore W1964037688C169760540 @default.