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- W1964055985 abstract "Atherosclerotic calcification is an organized, regulated process similar to bone formation that occurs only when other aspects of atherosclerosis are also present. Nonhepatic Gla-containing proteins like osteocalcin, which are actively involved in the transport of calcium out of vessel walls, are suspected to have key roles in the pathogenesis of coronary calcification. Osteopontin and its mRNA, known to be involved in bone mineralization, have been identified in calcified atherosclerotic lesions. Calcified human atherosclerotic plaque also contains mRNA for bone morphogenetic protein-2a, a potent factor for osteoblastic differentiation, and cells that are capable of osteoblastic differentiation. These cells may be the ones from which vascular calcifying cells are derived. These and other recent findings indicate that calcification is an active process and not simply a passive precipitation of calcium phosphate crystals, as once thought.Although calcification is found more frequently in advanced lesions, it may also occur in small amounts in earlier lesions that appear in the second and third decades of life. Histopathological investigation has shown that plaques with microscopic evidence of mineralization are larger and associated with larger coronary arteries than are plaques or arteries without calcification. The relation of arterial calcification to the probability of plaque rupture is unknown. Although the amount of coronary calcium correlates with the amount of atherosclerosis in different individuals and to a lesser extent in segments of the coronary tree in the same individuals, it is not known if the quantity of calcification tracks the quantity of atherosclerosis over time in the same individuals. Further research is needed to better elucidate the relation of calcification to the pathogenesis of both atherosclerosis and plaque rupture.In vivo epidemiological evidence and postmortem studies show that the prevalence of coronary calcium deposits in a given decade of life is 10 to 100 times higher than the …" @default.
- W1964055985 created "2016-06-24" @default.
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- W1964055985 date "1996-09-01" @default.
- W1964055985 modified "2023-10-17" @default.
- W1964055985 title "Coronary Artery Calcification: Pathophysiology, Epidemiology, Imaging Methods, and Clinical Implications" @default.
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