Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964063115> ?p ?o ?g. }
- W1964063115 endingPage "385" @default.
- W1964063115 startingPage "378" @default.
- W1964063115 abstract "Pancreatic α cells are exposed to metabolic stress during the evolution of type 2 diabetes (T2D), but it remains unclear whether this affects their survival. We used electron microscopy to search for markers of apoptosis and endoplasmic reticulum (ER) stress in α and β cells in islets from T2D or non-diabetic individuals. There was a significant increase in apoptotic β cells (from 0.4% in control to 6.0% in T2D), but no α cell apoptosis. We observed, however, similar ER stress in α and β cells from T2D patients. Human islets or fluorescence-activated cell sorting (FACS)-purified rat β and α cells exposed in vitro to the saturated free fatty acid palmitate showed a similar response as the T2D islets, i.e. both cell types showed signs of ER stress but only β cells progressed to apoptosis. Mechanistic experiments indicate that this α cell resistance to palmitate-induced apoptosis is explained, at least in part, by abundant expression of the anti-apoptotic protein Bcl2l1 (also known as Bcl-xL)." @default.
- W1964063115 created "2016-06-24" @default.
- W1964063115 creator A5000550995 @default.
- W1964063115 creator A5001886953 @default.
- W1964063115 creator A5005139318 @default.
- W1964063115 creator A5021270843 @default.
- W1964063115 creator A5048567884 @default.
- W1964063115 creator A5053174508 @default.
- W1964063115 creator A5056936819 @default.
- W1964063115 creator A5064248322 @default.
- W1964063115 creator A5067059021 @default.
- W1964063115 creator A5087771312 @default.
- W1964063115 date "2015-05-01" @default.
- W1964063115 modified "2023-09-27" @default.
- W1964063115 title "Pancreatic α Cells are Resistant to Metabolic Stress-induced Apoptosis in Type 2 Diabetes" @default.
- W1964063115 cites W146452825 @default.
- W1964063115 cites W1782483762 @default.
- W1964063115 cites W1966346152 @default.
- W1964063115 cites W1967659527 @default.
- W1964063115 cites W1968285615 @default.
- W1964063115 cites W1968836562 @default.
- W1964063115 cites W1970420856 @default.
- W1964063115 cites W1976315274 @default.
- W1964063115 cites W1977968768 @default.
- W1964063115 cites W1981433429 @default.
- W1964063115 cites W1983046008 @default.
- W1964063115 cites W2001252698 @default.
- W1964063115 cites W2003946536 @default.
- W1964063115 cites W2014506057 @default.
- W1964063115 cites W2042362312 @default.
- W1964063115 cites W2054714044 @default.
- W1964063115 cites W2058239853 @default.
- W1964063115 cites W2061574308 @default.
- W1964063115 cites W2071755562 @default.
- W1964063115 cites W2074549465 @default.
- W1964063115 cites W2082515526 @default.
- W1964063115 cites W2091035564 @default.
- W1964063115 cites W2091903300 @default.
- W1964063115 cites W2093867346 @default.
- W1964063115 cites W2095577197 @default.
- W1964063115 cites W2101874536 @default.
- W1964063115 cites W2105699709 @default.
- W1964063115 cites W2109971798 @default.
- W1964063115 cites W2113544353 @default.
- W1964063115 cites W2117074858 @default.
- W1964063115 cites W2120653342 @default.
- W1964063115 cites W2126610675 @default.
- W1964063115 cites W2130326770 @default.
- W1964063115 cites W2138100580 @default.
- W1964063115 cites W2142536100 @default.
- W1964063115 cites W2143256430 @default.
- W1964063115 cites W2151820006 @default.
- W1964063115 cites W2162333519 @default.
- W1964063115 cites W2168530080 @default.
- W1964063115 cites W2171289415 @default.
- W1964063115 cites W2192080449 @default.
- W1964063115 cites W2887036954 @default.
- W1964063115 doi "https://doi.org/10.1016/j.ebiom.2015.03.012" @default.
- W1964063115 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4485913" @default.
- W1964063115 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26137583" @default.
- W1964063115 hasPublicationYear "2015" @default.
- W1964063115 type Work @default.
- W1964063115 sameAs 1964063115 @default.
- W1964063115 citedByCount "79" @default.
- W1964063115 countsByYear W19640631152012 @default.
- W1964063115 countsByYear W19640631152015 @default.
- W1964063115 countsByYear W19640631152016 @default.
- W1964063115 countsByYear W19640631152017 @default.
- W1964063115 countsByYear W19640631152018 @default.
- W1964063115 countsByYear W19640631152019 @default.
- W1964063115 countsByYear W19640631152020 @default.
- W1964063115 countsByYear W19640631152021 @default.
- W1964063115 countsByYear W19640631152022 @default.
- W1964063115 countsByYear W19640631152023 @default.
- W1964063115 crossrefType "journal-article" @default.
- W1964063115 hasAuthorship W1964063115A5000550995 @default.
- W1964063115 hasAuthorship W1964063115A5001886953 @default.
- W1964063115 hasAuthorship W1964063115A5005139318 @default.
- W1964063115 hasAuthorship W1964063115A5021270843 @default.
- W1964063115 hasAuthorship W1964063115A5048567884 @default.
- W1964063115 hasAuthorship W1964063115A5053174508 @default.
- W1964063115 hasAuthorship W1964063115A5056936819 @default.
- W1964063115 hasAuthorship W1964063115A5064248322 @default.
- W1964063115 hasAuthorship W1964063115A5067059021 @default.
- W1964063115 hasAuthorship W1964063115A5087771312 @default.
- W1964063115 hasBestOaLocation W19640631151 @default.
- W1964063115 hasConcept C126322002 @default.
- W1964063115 hasConcept C134018914 @default.
- W1964063115 hasConcept C139447449 @default.
- W1964063115 hasConcept C1491633281 @default.
- W1964063115 hasConcept C158617107 @default.
- W1964063115 hasConcept C165220095 @default.
- W1964063115 hasConcept C185592680 @default.
- W1964063115 hasConcept C189014844 @default.
- W1964063115 hasConcept C190283241 @default.
- W1964063115 hasConcept C2777180221 @default.
- W1964063115 hasConcept C2778630268 @default.
- W1964063115 hasConcept C2778764654 @default.