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• W1964069111 startingPage "107" @default.
• W1964069111 abstract "Ovarian development in the domesticated silkmoth, Bombyx mori, is induced by the molting hormone 20-hydroxy-ecdysone (20E) shortly after larval-pupal ecdysis. Studies of the ecdysone response in Drosophila and other insects have shown that 20E exerts its effects initially by the induction of a small number of early genes, including the orphan nuclear receptors HR3, that transduce and amplify the hormone signal. Here we show that the silkmoth orphan receptor BmHR3A acts in the 20E-induced regulatory cascade in the ovary during pupal and pharate adult development in a manner different than that observed in the classical ecdysone regulatory hierarchy in Drosophila salivary glands at the end of the third instar. While other isoforms of BmHR3 are induced as early gene products in the ecdysone response, BmHR3A is induced 2 days after 20E administration in the silkmoth ovary and, thus, behaves as late product. The period of accumulation of BmHR3A in ovarian follicular cells occurs during vitellogenesis and coincides with the period of transcriptional expression of the ESP (egg-specific protein) gene, whose product constitutes a major component of the egg yolk, while it is reciprocal to the period of expression of BmGATAbeta, a gene encoding a regulator of late chorion gene expression. Bandshift experiments demonstrate that BmHR3A binds specifically to RORE (Retinoic acid-related Orphan receptor Response Element)-like sequences in the promoters of both genes, thus suggesting a direct role for BmHR3A in regulating the expression of BmGATAbeta and ESP genes during vitellogenesis. Finally, we show that BmHR3A functions as a constitutive transcriptional activator in a B. mori derived cell line. We propose that BmHR3A may function as a regulator of vitellogenesis in the silkmoth ovary." @default.
• W1964069111 created "2016-06-24" @default.
• W1964069111 creator A5008587221 @default.
• W1964069111 creator A5012210879 @default.
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• W1964069111 date "2001-05-01" @default.
• W1964069111 modified "2023-10-18" @default.
• W1964069111 title "The orphan nuclear receptor BmHR3A of Bombyx mori: hormonal control, ovarian expression and functional properties" @default.
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• W1964069111 doi "https://doi.org/10.1016/s0925-4773(01)00335-5" @default.
• W1964069111 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11335116" @default.
• W1964069111 hasPublicationYear "2001" @default.
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