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- W1964071354 abstract "Proteases form stable complexes with α<sub>2</sub>-macroglobin (α<sub>2</sub>-MG) in human plasma. We previously showed that the intestine of newborn rabbits takes up greater amounts of proteases than the intestine of weaned animals, and we suggested that the same phenomenon might occur in the human newborn. To test this possibility, α<sub>2</sub>-MG complexes were sought in plasma from 3-day-old human infants and adults. In addition, the level of α<sub>2</sub>-MG was measured. The concentration of α<sub>2</sub>-MG complexes and of α<sub>2</sub>-MG was significantly increased in the plasma of infants compared to adults. We suggest that the elevated levels of α<sub>2</sub>-MG complexes in infants may reflect the enhanced uptake of proteases from the intestine. In addition, there may also be decreased clearance of complexes by the mononuclear phagocytic system in infants. The elevated levels of α<sub>2</sub>-MG in the infant may reflect a response to the need for neutralizing proteases absorbed from the intestine." @default.
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- W1964071354 date "1987-01-01" @default.
- W1964071354 modified "2023-10-17" @default.
- W1964071354 title "Elevated Levels of α<sub>2</sub>-Macroglobulin-Protease Complexes in Infants" @default.
- W1964071354 doi "https://doi.org/10.1159/000242646" @default.
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