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- W1964081998 abstract "Background: Neonatal lupus erythematosus (NLE) is a syndrome characterized by dermatitis and congenital heart block (CHB). The disease is mostly associated with transplacental passage of maternal anti-Ro/SSA and/or La/SSB antibodies.Objective: To examine maternal autoimmune response to recombinant Ro/SSA and La/SSB proteins in NLE with a single ethnic background.Methods: This study examined 12 NLE infants and their mothers. Serum samples were tested by enzyme-linked immunosorbent assay for reactivity with full-length recombinant human 60-kd Ro/SSA, 52-kd Ro/SSA, and 48-kd La/SSB proteins.Results: All 10 infants with skin lesions and/or CHB had maternal antibodies reactive to both the 60-and 52-kd Ro/SSA polypeptide components of the Ro/SSA particle. Anti-60-kd Ro/SSA without anti-52-kd Ro/SSA, or vice versa, was found in mothers of infants who had only hepatic manifestation of NLE. Nine of 12 NLE infants had anti-48-kd La/SSB.Conclusion: In the majority of Japanese infants with NLE, maternal anti-Ro/SSA a..." @default.
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- W1964081998 date "1995-01-01" @default.
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- W1964081998 title "Maternal Autoimmune Response to Recombinant RO/SSA and LA/SSB Proteins in Japanese Neonatal Lupus Erythem Atosus" @default.
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- W1964081998 doi "https://doi.org/10.3109/08916939509001947" @default.
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