FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964082418> ?p ?o ?g. }

• W1964082418 endingPage "4675" @default.
• W1964082418 startingPage "4670" @default.
• W1964082418 abstract "Social recognition constitutes the basis of social life. In male mice and rats, social recognition is known to be governed by the neuropeptide oxytocin (OT) through its action on OT receptors (OTRs) in the medial amygdala. In female rats and mice, which have sociosexual behaviors controlling substantial investment in reproduction, an important role for OT in sociosexual behaviors has also been shown. However, the site in the female brain for OT action on social recognition is still unknown. Here we used a customized, controlled release system of biodegradable polymeric microparticles to deliver, in the medial amygdala of female mice, “locked nucleic acid” antisense (AS) oligonucleotides with sequences specific for the mRNA of the OTR gene. We found that single bilateral intraamygdala injections of OTR AS locked nucleic acid oligonucleotides several days before behavioral testing reduced social recognition. Thus, we showed that gene expression for OTR specifically in the amygdala is required for normal social recognition in female mice. Importantly, during the same experiment, we performed a detailed ethological analysis of mouse behavior revealing that OTR AS-treated mice underwent an initial increase in ambivalent risk-assessment behavior. Other behaviors were not affected, thus revealing specific roles for amygdala OTR in female social recognition potentially mediated by anxiety in a social context. Understanding the functional genomics of OT and OTR in social recognition should help elucidate the neurobiological bases of human disorders of social behavior (e.g., autism)." @default.
• W1964082418 created "2016-06-24" @default.
• W1964082418 creator A5020913453 @default.
• W1964082418 creator A5037109370 @default.
• W1964082418 creator A5046667604 @default.
• W1964082418 creator A5047316720 @default.
• W1964082418 creator A5056101325 @default.
• W1964082418 creator A5086866710 @default.
• W1964082418 date "2007-03-13" @default.
• W1964082418 modified "2023-09-25" @default.
• W1964082418 title "Microparticle-based delivery of oxytocin receptor antisense DNA in the medial amygdala blocks social recognition in female mice" @default.
• W1964082418 cites W1528771346 @default.
• W1964082418 cites W1568196828 @default.
• W1964082418 cites W1602757251 @default.
• W1964082418 cites W1608517055 @default.
• W1964082418 cites W1624382596 @default.
• W1964082418 cites W1948173875 @default.
• W1964082418 cites W1967332094 @default.
• W1964082418 cites W1982469667 @default.
• W1964082418 cites W1986486558 @default.
• W1964082418 cites W1989350280 @default.
• W1964082418 cites W1990967207 @default.
• W1964082418 cites W1992990293 @default.
• W1964082418 cites W1993403025 @default.
• W1964082418 cites W2008293884 @default.
• W1964082418 cites W2009459640 @default.
• W1964082418 cites W2014726218 @default.
• W1964082418 cites W2015018404 @default.
• W1964082418 cites W2016243825 @default.
• W1964082418 cites W2017436597 @default.
• W1964082418 cites W2021066251 @default.
• W1964082418 cites W2024244702 @default.
• W1964082418 cites W2028205982 @default.
• W1964082418 cites W2032105230 @default.
• W1964082418 cites W2033794962 @default.
• W1964082418 cites W2034261103 @default.
• W1964082418 cites W2035269878 @default.
• W1964082418 cites W2040269228 @default.
• W1964082418 cites W2040553957 @default.
• W1964082418 cites W2046845715 @default.
• W1964082418 cites W2047027389 @default.
• W1964082418 cites W2048408942 @default.
• W1964082418 cites W2055266348 @default.
• W1964082418 cites W2062505106 @default.
• W1964082418 cites W2064696930 @default.
• W1964082418 cites W2069334714 @default.
• W1964082418 cites W2069519651 @default.
• W1964082418 cites W2071543008 @default.
• W1964082418 cites W2072080093 @default.
• W1964082418 cites W2076441371 @default.
• W1964082418 cites W2077608143 @default.
• W1964082418 cites W2080066082 @default.
• W1964082418 cites W2085700560 @default.
• W1964082418 cites W2086886701 @default.
• W1964082418 cites W2087335405 @default.
• W1964082418 cites W2092970202 @default.
• W1964082418 cites W2092980959 @default.
• W1964082418 cites W2095808811 @default.
• W1964082418 cites W2101014059 @default.
• W1964082418 cites W2113872892 @default.
• W1964082418 cites W2120911628 @default.
• W1964082418 cites W2122297603 @default.
• W1964082418 cites W2151841284 @default.
• W1964082418 cites W2162294498 @default.
• W1964082418 cites W2163053496 @default.
• W1964082418 cites W2164671673 @default.
• W1964082418 cites W4236617877 @default.
• W1964082418 cites W4236841827 @default.
• W1964082418 doi "https://doi.org/10.1073/pnas.0700670104" @default.
• W1964082418 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1838659" @default.
• W1964082418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17360582" @default.
• W1964082418 hasPublicationYear "2007" @default.
• W1964082418 type Work @default.
• W1964082418 sameAs 1964082418 @default.
• W1964082418 citedByCount "169" @default.
• W1964082418 countsByYear W19640824182012 @default.
• W1964082418 countsByYear W19640824182013 @default.
• W1964082418 countsByYear W19640824182014 @default.
• W1964082418 countsByYear W19640824182015 @default.
• W1964082418 countsByYear W19640824182016 @default.
• W1964082418 countsByYear W19640824182017 @default.
• W1964082418 countsByYear W19640824182018 @default.
• W1964082418 countsByYear W19640824182019 @default.
• W1964082418 countsByYear W19640824182020 @default.
• W1964082418 countsByYear W19640824182021 @default.
• W1964082418 countsByYear W19640824182022 @default.
• W1964082418 countsByYear W19640824182023 @default.
• W1964082418 crossrefType "journal-article" @default.
• W1964082418 hasAuthorship W1964082418A5020913453 @default.
• W1964082418 hasAuthorship W1964082418A5037109370 @default.
• W1964082418 hasAuthorship W1964082418A5046667604 @default.
• W1964082418 hasAuthorship W1964082418A5047316720 @default.
• W1964082418 hasAuthorship W1964082418A5056101325 @default.
• W1964082418 hasAuthorship W1964082418A5086866710 @default.
• W1964082418 hasBestOaLocation W19640824182 @default.
• W1964082418 hasConcept C134018914 @default.
• W1964082418 hasConcept C15744967 @default.
• W1964082418 hasConcept C169760540 @default.

• next