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• W1964089296 startingPage "132" @default.
• W1964089296 abstract "Alternative splicing results in multiple protein isoforms derived from a single gene. The magnitude of this process ranges from a complete loss of function to gain of new function. We examined, as a paradigm, alternative splicing of the non-redundant human cytokine, interleukin-7 (IL-7). We show that extensive IL-7 splicing in human tissues of different histology, including MTB+ granuloma lesions, transformed tissue and tumor cell lines. IL-7 splice variants were expressed as recombinant proteins. A differentially spliced IL-7 isoform, lacking exon 5, leads to STAT-5 phosphorylation in CD4+ and CD8+ T cells, promotes thymocyte maturation and T-cell survival. Human tumor lesions show aberrant IL-7 isoform expression, as compared with the autologous, non-transformed tissue. Alternatively spliced cytokines, such as IL-7, represent candidates for diagnostics and therapeutic interventions." @default.
• W1964089296 created "2016-06-24" @default.
• W1964089296 creator A5006698445 @default.
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• W1964089296 date "2008-12-18" @default.
• W1964089296 modified "2023-09-25" @default.
• W1964089296 title "Expression analysis and functional activity of interleukin-7 splice variants" @default.
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• W1964089296 doi "https://doi.org/10.1038/gene.2008.90" @default.
• W1964089296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19092841" @default.
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