Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964089628> ?p ?o ?g. }
- W1964089628 endingPage "e35457" @default.
- W1964089628 startingPage "e35457" @default.
- W1964089628 abstract "Modified gangliosides may be overexpressed in certain types of cancer, thus, they are considered a valuable target in cancer immunotherapy. Structural knowledge of their interaction with antibodies is currently limited, due to the large size and high flexibility of these ligands. In this study, we apply our previously developed site mapping technique to investigate the recognition of cancer-related gangliosides by anti-ganglioside antibodies. The results reveal a potential ganglioside-binding motif in the four antibodies studied, suggesting the possibility of structural convergence in the anti-ganglioside immune response. The structural basis of the recognition of ganglioside-mimetic peptides is also investigated using site mapping and compared to ganglioside recognition. The peptides are shown to act as structural mimics of gangliosides by interacting with many of the same binding site residues as the cognate carbohydrate epitopes. These studies provide important clues as to the structural basis of immunological mimicry of carbohydrates." @default.
- W1964089628 created "2016-06-24" @default.
- W1964089628 creator A5031224982 @default.
- W1964089628 creator A5045316156 @default.
- W1964089628 creator A5085784277 @default.
- W1964089628 date "2012-04-20" @default.
- W1964089628 modified "2023-09-25" @default.
- W1964089628 title "Antibody Recognition of Cancer-Related Gangliosides and Their Mimics Investigated Using in silico Site Mapping" @default.
- W1964089628 cites W1506897962 @default.
- W1964089628 cites W1550802353 @default.
- W1964089628 cites W1964126053 @default.
- W1964089628 cites W1973832527 @default.
- W1964089628 cites W1975593674 @default.
- W1964089628 cites W1976166050 @default.
- W1964089628 cites W1982679430 @default.
- W1964089628 cites W1985588649 @default.
- W1964089628 cites W1985774086 @default.
- W1964089628 cites W1988422289 @default.
- W1964089628 cites W1989089334 @default.
- W1964089628 cites W1989321959 @default.
- W1964089628 cites W1989652867 @default.
- W1964089628 cites W2001281410 @default.
- W1964089628 cites W2005755609 @default.
- W1964089628 cites W2011796931 @default.
- W1964089628 cites W2023083727 @default.
- W1964089628 cites W2026187161 @default.
- W1964089628 cites W2029561230 @default.
- W1964089628 cites W2031513585 @default.
- W1964089628 cites W2038614347 @default.
- W1964089628 cites W2038862452 @default.
- W1964089628 cites W2044864736 @default.
- W1964089628 cites W2047270330 @default.
- W1964089628 cites W2049786239 @default.
- W1964089628 cites W2049813585 @default.
- W1964089628 cites W2050381667 @default.
- W1964089628 cites W2052030759 @default.
- W1964089628 cites W2053116848 @default.
- W1964089628 cites W2058021541 @default.
- W1964089628 cites W2066735040 @default.
- W1964089628 cites W2068803938 @default.
- W1964089628 cites W2075980472 @default.
- W1964089628 cites W2077366392 @default.
- W1964089628 cites W2081912151 @default.
- W1964089628 cites W2087585684 @default.
- W1964089628 cites W2087916187 @default.
- W1964089628 cites W2092028720 @default.
- W1964089628 cites W2092221872 @default.
- W1964089628 cites W2093062941 @default.
- W1964089628 cites W2096266806 @default.
- W1964089628 cites W2102075177 @default.
- W1964089628 cites W2104194763 @default.
- W1964089628 cites W2110283222 @default.
- W1964089628 cites W2111913722 @default.
- W1964089628 cites W2116060868 @default.
- W1964089628 cites W2119106999 @default.
- W1964089628 cites W2129736975 @default.
- W1964089628 cites W2131599497 @default.
- W1964089628 cites W2136073282 @default.
- W1964089628 cites W2136482421 @default.
- W1964089628 cites W2141999865 @default.
- W1964089628 cites W2143467722 @default.
- W1964089628 cites W2149658535 @default.
- W1964089628 cites W2156447511 @default.
- W1964089628 cites W2158534713 @default.
- W1964089628 cites W2160205549 @default.
- W1964089628 cites W2227399362 @default.
- W1964089628 cites W4229892776 @default.
- W1964089628 doi "https://doi.org/10.1371/journal.pone.0035457" @default.
- W1964089628 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3334985" @default.
- W1964089628 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22536387" @default.
- W1964089628 hasPublicationYear "2012" @default.
- W1964089628 type Work @default.
- W1964089628 sameAs 1964089628 @default.
- W1964089628 citedByCount "17" @default.
- W1964089628 countsByYear W19640896282013 @default.
- W1964089628 countsByYear W19640896282014 @default.
- W1964089628 countsByYear W19640896282015 @default.
- W1964089628 countsByYear W19640896282017 @default.
- W1964089628 countsByYear W19640896282018 @default.
- W1964089628 countsByYear W19640896282020 @default.
- W1964089628 countsByYear W19640896282022 @default.
- W1964089628 crossrefType "journal-article" @default.
- W1964089628 hasAuthorship W1964089628A5031224982 @default.
- W1964089628 hasAuthorship W1964089628A5045316156 @default.
- W1964089628 hasAuthorship W1964089628A5085784277 @default.
- W1964089628 hasBestOaLocation W19640896281 @default.
- W1964089628 hasConcept C104317684 @default.
- W1964089628 hasConcept C107824862 @default.
- W1964089628 hasConcept C159654299 @default.
- W1964089628 hasConcept C185592680 @default.
- W1964089628 hasConcept C195616568 @default.
- W1964089628 hasConcept C203014093 @default.
- W1964089628 hasConcept C2775905019 @default.
- W1964089628 hasConcept C2777119779 @default.
- W1964089628 hasConcept C2777331542 @default.
- W1964089628 hasConcept C55493867 @default.
- W1964089628 hasConcept C70721500 @default.
- W1964089628 hasConcept C86803240 @default.