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- W1964094833 abstract "Modern peptide chemistry is based on the solid-phase approach developed originally by Bruce Merrifield in the sixties. This and the previous issue of Peptide Science (Volume 55, Issue 2) corroborates the prediction of Merrifield when he said that “… it seems quite clear that a gold mine is awaiting the organic chemist who would look to solid supports for controlling and directing his synthetic reactions.” [R. B. Merrifield, “Solid Phase Synthesis,” Advances in Enzymology 32, 221–296 (1969)]. In this issue of Peptide Science, the first two papers from Wenschuh and co-workers, and by Maeji and co-workers, describe solid supports different from the conventional gel-type ones, such as polystyrene, polyamide, or polyethyleneglycol grafted on polystyrene. Thus, membranes and “pellicular” supports are very convenient for both elongation of the peptidic chain in a multisynthesis mode and for the high-throughput solid-phase screening of the peptides synthesized on them. The synthesis of large peptides or small proteins is especially challenging. Alewood and co-workers cover in their chapter the state-of-the-art in the step-wise synthesis of these biomolecules using the solid-phase approach. Purity of the final products demonstrates the feasibility of the strategies outlined in the manuscript. Finally, the paper by Verlander and co-workers is focused on the practical aspects of the application of chemical synthesis methods to the large-scale production of peptides. This work is a perfect example of the idea that both strategies, solid-phase and solution, are perfectly compatible. Methods used for large-scale purification and isolation of final products are evaluated, together with a discussion of regulatory issues encountered during the scale-up of the process. It is hoped that this issue of Peptide Science, in tandem with the previous issue, serve to provide a comprehensive assessment of the reagents, strategies, and materials typifying the current state-of-the-art in peptide chemistry, and that the reader will find both issues informative and enjoyable." @default.
- W1964094833 created "2016-06-24" @default.
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- W1964094833 date "2000-01-01" @default.
- W1964094833 modified "2023-10-10" @default.
- W1964094833 title "Editorial: Current perspectives in peptide chemistry. II. Supports" @default.
- W1964094833 doi "https://doi.org/10.1002/1097-0282(2000)55:3<187::aid-bip10>3.0.co;2-v" @default.
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