Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964112324> ?p ?o ?g. }
- W1964112324 endingPage "89" @default.
- W1964112324 startingPage "81" @default.
- W1964112324 abstract "Oral squamous cell carcinoma (OSCC), like many solid tumors, contains a heterogeneous population of cancer cells. Recent data suggest that a rare subpopulation of cancer cells, known as cancer stem cells (CSCs), is capable of initiating, maintaining, and expanding the growth of tumors. Identification and characterization of CSCs from OSCC would facilitate the monitoring, therapy, or prevention of this cancer. CD133 is considered a marker molecule for CSCs; however, its role in OSCC is yet to be determined. In this study, we isolated CD133-positive cells from OSCC cell lines using a magnetic-activated cell sorter (MACS). The differential expression of genes between OSCC/CD133-positive cells and parental cells was determined by polymerase chain reaction (PCR). Up-regulated genes (CD133-positive vs. parental cells) included ALDH 1, Keratin15 (Krt15), SOX2, and WNT 1, while the down-regulated genes included Fgfr1 and Pparg. Additionally, immunohistochemical analysis revealed that expression of Krt15 and SOX2 was localized to cancer cells of OSCC specimens. Their elevated expression levels were detected in poorly differentiated and chemoresistant OSCC. Our results possibly demonstrate that CD133-positive cells, when compared with parental cells, are a more concentrated population of CSCs in OSCC." @default.
- W1964112324 created "2016-06-24" @default.
- W1964112324 creator A5000799694 @default.
- W1964112324 creator A5020224299 @default.
- W1964112324 creator A5053341820 @default.
- W1964112324 creator A5067858921 @default.
- W1964112324 creator A5073624654 @default.
- W1964112324 date "2012-01-01" @default.
- W1964112324 modified "2023-10-16" @default.
- W1964112324 title "Gene Expression of Cancer Stem Cell in Oral Squamous Cell Carcinoma" @default.
- W1964112324 cites W1596473475 @default.
- W1964112324 cites W1967245224 @default.
- W1964112324 cites W1990099538 @default.
- W1964112324 cites W1993302385 @default.
- W1964112324 cites W2001617354 @default.
- W1964112324 cites W2011917769 @default.
- W1964112324 cites W2013614359 @default.
- W1964112324 cites W2023316892 @default.
- W1964112324 cites W2026865704 @default.
- W1964112324 cites W2034514595 @default.
- W1964112324 cites W2036795046 @default.
- W1964112324 cites W2037153840 @default.
- W1964112324 cites W2038873665 @default.
- W1964112324 cites W2056598800 @default.
- W1964112324 cites W2056639832 @default.
- W1964112324 cites W2064457163 @default.
- W1964112324 cites W2073759231 @default.
- W1964112324 cites W2083632015 @default.
- W1964112324 cites W2089631233 @default.
- W1964112324 cites W2100221605 @default.
- W1964112324 cites W2151011478 @default.
- W1964112324 cites W2151386025 @default.
- W1964112324 cites W2153382986 @default.
- W1964112324 cites W2156891963 @default.
- W1964112324 cites W2159999899 @default.
- W1964112324 cites W2164587626 @default.
- W1964112324 cites W2167650288 @default.
- W1964112324 cites W2169529166 @default.
- W1964112324 cites W2109365948 @default.
- W1964112324 doi "https://doi.org/10.7881/dentalmedres.32.81" @default.
- W1964112324 hasPublicationYear "2012" @default.
- W1964112324 type Work @default.
- W1964112324 sameAs 1964112324 @default.
- W1964112324 citedByCount "0" @default.
- W1964112324 crossrefType "journal-article" @default.
- W1964112324 hasAuthorship W1964112324A5000799694 @default.
- W1964112324 hasAuthorship W1964112324A5020224299 @default.
- W1964112324 hasAuthorship W1964112324A5053341820 @default.
- W1964112324 hasAuthorship W1964112324A5067858921 @default.
- W1964112324 hasAuthorship W1964112324A5073624654 @default.
- W1964112324 hasBestOaLocation W19641123241 @default.
- W1964112324 hasConcept C104317684 @default.
- W1964112324 hasConcept C121608353 @default.
- W1964112324 hasConcept C137620995 @default.
- W1964112324 hasConcept C142724271 @default.
- W1964112324 hasConcept C145103041 @default.
- W1964112324 hasConcept C1491633281 @default.
- W1964112324 hasConcept C2777933648 @default.
- W1964112324 hasConcept C2780546549 @default.
- W1964112324 hasConcept C2780932548 @default.
- W1964112324 hasConcept C28328180 @default.
- W1964112324 hasConcept C2908647359 @default.
- W1964112324 hasConcept C502942594 @default.
- W1964112324 hasConcept C54355233 @default.
- W1964112324 hasConcept C55427017 @default.
- W1964112324 hasConcept C71924100 @default.
- W1964112324 hasConcept C86803240 @default.
- W1964112324 hasConcept C95444343 @default.
- W1964112324 hasConcept C96232424 @default.
- W1964112324 hasConcept C99454951 @default.
- W1964112324 hasConceptScore W1964112324C104317684 @default.
- W1964112324 hasConceptScore W1964112324C121608353 @default.
- W1964112324 hasConceptScore W1964112324C137620995 @default.
- W1964112324 hasConceptScore W1964112324C142724271 @default.
- W1964112324 hasConceptScore W1964112324C145103041 @default.
- W1964112324 hasConceptScore W1964112324C1491633281 @default.
- W1964112324 hasConceptScore W1964112324C2777933648 @default.
- W1964112324 hasConceptScore W1964112324C2780546549 @default.
- W1964112324 hasConceptScore W1964112324C2780932548 @default.
- W1964112324 hasConceptScore W1964112324C28328180 @default.
- W1964112324 hasConceptScore W1964112324C2908647359 @default.
- W1964112324 hasConceptScore W1964112324C502942594 @default.
- W1964112324 hasConceptScore W1964112324C54355233 @default.
- W1964112324 hasConceptScore W1964112324C55427017 @default.
- W1964112324 hasConceptScore W1964112324C71924100 @default.
- W1964112324 hasConceptScore W1964112324C86803240 @default.
- W1964112324 hasConceptScore W1964112324C95444343 @default.
- W1964112324 hasConceptScore W1964112324C96232424 @default.
- W1964112324 hasConceptScore W1964112324C99454951 @default.
- W1964112324 hasIssue "2" @default.
- W1964112324 hasLocation W19641123241 @default.
- W1964112324 hasOpenAccess W1964112324 @default.
- W1964112324 hasPrimaryLocation W19641123241 @default.
- W1964112324 hasRelatedWork W1538961437 @default.
- W1964112324 hasRelatedWork W2032183382 @default.
- W1964112324 hasRelatedWork W2068445725 @default.
- W1964112324 hasRelatedWork W2098447236 @default.
- W1964112324 hasRelatedWork W2118577068 @default.