Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964122009> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W1964122009 endingPage "782" @default.
- W1964122009 startingPage "777" @default.
- W1964122009 abstract "Male subjects administered the 5 alpha-reductase inhibitor finasteride were studied to determine its effect on C19 and C21 5 alpha-metabolism. Plasma testosterone (T) and 5 alpha-dihydrotestosterone (DHT) were measured and T/DHT ratios determined at doses of 0.2-80 mg. Urinary etiocholanolone (5 beta)/androsterone (5 alpha) ratios and 5 beta/5 alpha metabolite ratios of cortisol, 11 beta-hydroxyandrostenedione, and corticosterone were also measured. The steroid profile was compared to male pseudohermaphrodites with inherited 5 alpha-reductase deficiency who have a global defect in C19 and C21 5 alpha-metabolism. The mean plasma DHT levels were decreased at all doses, resulting in elevated T/DHT ratios. The mean urinary etiocholanolone/androsterone, 11 beta-hydroxyetiocholanolone/11 beta-hydroxyandrosterone, tetrahydrocortisol/allotetrahydrocortisol, and tetrahydrocorticosterone/allotetrahydrocorticosterone ratios were elevated compared to pretreatment levels and placebo control values. The mean ratios appeared to be dose dependent for plasma T/DHT, urinary etiocholanolone/androsterone tetrahydrocorticosterone/allotetrahydrocorticosterone ratios. The mean 11 beta-hydroxyetiocholanolone-hydroxyandrosterone ratio was maximally elevated at the lowest doses. The results indicate that finasteride has a broad steroid spectrum inhibiting C19 and C21 5 alpha-steroid metabolism and affecting hepatic and peripheral 5 alpha-metabolism. These results suggest that a single gene codes for a single 5 alpha-reductase enzyme with affinity for multiple steroid substrates. The steroid profile is strikingly similar to that of male pseudohermaphrodites with inherited 5 alpha-reductase deficiency." @default.
- W1964122009 created "2016-06-24" @default.
- W1964122009 creator A5016800048 @default.
- W1964122009 creator A5050395853 @default.
- W1964122009 creator A5064771943 @default.
- W1964122009 creator A5066506819 @default.
- W1964122009 date "1990-03-01" @default.
- W1964122009 modified "2023-10-16" @default.
- W1964122009 title "C<sub>19</sub>and C<sub>21</sub>5<i>β</i>/5<i>α</i>Metabolite Ratios in Subjects Treated with the 5<i>α</i>-Reductase Inhibitor Finasteride: Comparison of Male Pseudohermaphrodites with Inherited 5<i>α</i>-Reductase Deficiency*" @default.
- W1964122009 doi "https://doi.org/10.1210/jcem-70-3-777" @default.
- W1964122009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1689740" @default.
- W1964122009 hasPublicationYear "1990" @default.
- W1964122009 type Work @default.
- W1964122009 sameAs 1964122009 @default.
- W1964122009 citedByCount "56" @default.
- W1964122009 countsByYear W19641220092012 @default.
- W1964122009 countsByYear W19641220092013 @default.
- W1964122009 countsByYear W19641220092015 @default.
- W1964122009 countsByYear W19641220092017 @default.
- W1964122009 countsByYear W19641220092018 @default.
- W1964122009 countsByYear W19641220092021 @default.
- W1964122009 countsByYear W19641220092023 @default.
- W1964122009 crossrefType "journal-article" @default.
- W1964122009 hasAuthorship W1964122009A5016800048 @default.
- W1964122009 hasAuthorship W1964122009A5050395853 @default.
- W1964122009 hasAuthorship W1964122009A5064771943 @default.
- W1964122009 hasAuthorship W1964122009A5066506819 @default.
- W1964122009 hasConcept C121608353 @default.
- W1964122009 hasConcept C126322002 @default.
- W1964122009 hasConcept C134018914 @default.
- W1964122009 hasConcept C185592680 @default.
- W1964122009 hasConcept C2775874879 @default.
- W1964122009 hasConcept C2776235491 @default.
- W1964122009 hasConcept C2777344897 @default.
- W1964122009 hasConcept C2777477808 @default.
- W1964122009 hasConcept C2777911890 @default.
- W1964122009 hasConcept C2779279991 @default.
- W1964122009 hasConcept C2779746161 @default.
- W1964122009 hasConcept C2779881493 @default.
- W1964122009 hasConcept C2780902042 @default.
- W1964122009 hasConcept C2910366748 @default.
- W1964122009 hasConcept C71315377 @default.
- W1964122009 hasConcept C71924100 @default.
- W1964122009 hasConcept C86803240 @default.
- W1964122009 hasConceptScore W1964122009C121608353 @default.
- W1964122009 hasConceptScore W1964122009C126322002 @default.
- W1964122009 hasConceptScore W1964122009C134018914 @default.
- W1964122009 hasConceptScore W1964122009C185592680 @default.
- W1964122009 hasConceptScore W1964122009C2775874879 @default.
- W1964122009 hasConceptScore W1964122009C2776235491 @default.
- W1964122009 hasConceptScore W1964122009C2777344897 @default.
- W1964122009 hasConceptScore W1964122009C2777477808 @default.
- W1964122009 hasConceptScore W1964122009C2777911890 @default.
- W1964122009 hasConceptScore W1964122009C2779279991 @default.
- W1964122009 hasConceptScore W1964122009C2779746161 @default.
- W1964122009 hasConceptScore W1964122009C2779881493 @default.
- W1964122009 hasConceptScore W1964122009C2780902042 @default.
- W1964122009 hasConceptScore W1964122009C2910366748 @default.
- W1964122009 hasConceptScore W1964122009C71315377 @default.
- W1964122009 hasConceptScore W1964122009C71924100 @default.
- W1964122009 hasConceptScore W1964122009C86803240 @default.
- W1964122009 hasIssue "3" @default.
- W1964122009 hasLocation W19641220091 @default.
- W1964122009 hasLocation W19641220092 @default.
- W1964122009 hasOpenAccess W1964122009 @default.
- W1964122009 hasPrimaryLocation W19641220091 @default.
- W1964122009 hasRelatedWork W1967975371 @default.
- W1964122009 hasRelatedWork W1971529801 @default.
- W1964122009 hasRelatedWork W1979452793 @default.
- W1964122009 hasRelatedWork W1981433740 @default.
- W1964122009 hasRelatedWork W2002995968 @default.
- W1964122009 hasRelatedWork W2038277505 @default.
- W1964122009 hasRelatedWork W2053511509 @default.
- W1964122009 hasRelatedWork W2074441798 @default.
- W1964122009 hasRelatedWork W2079213361 @default.
- W1964122009 hasRelatedWork W2083564258 @default.
- W1964122009 hasVolume "70" @default.
- W1964122009 isParatext "false" @default.
- W1964122009 isRetracted "false" @default.
- W1964122009 magId "1964122009" @default.
- W1964122009 workType "article" @default.