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• W1964135958 endingPage "145" @default.
• W1964135958 startingPage "128" @default.
• W1964135958 abstract "Cytochromes P450 are ubiquitously distributed enzymes, which were discovered about 50 years ago and which possess high complexity and display a broad field of activity. They are hemoproteins encoded by a superfamily of genes converting a broad variety of substrates and catalysing a variety of interesting chemical reactions. This enzyme family is involved in the biotransformation of drugs, the bioconversion of xenobiotics, the metabolism of chemical carcinogens, the biosynthesis of physiologically important compounds such as steroids, fatty acids, eicosanoids, fat-soluble vitamins, bile acids, the conversion of alkanes, terpenes, and aromatic compounds as well as the degradation of herbicides and insecticides. There is also a broad versatility of reactions catalysed by cytochromes P450 such as carbon hydroxylation, heteroatom oxygenation, dealkylation, epoxidation, aromatic hydroxylation, reduction, dehalogenation (Sono, M., Roach, M.P., Coulter, E.D., Dawson, J.H., 1996. Heme-containing oxygenases. Chem. Rev. 96, 2841–2888), (Werck-Reichhart, D., Feyereisen, R., 2000. Cytochromes P450: a success story. Genome Biol. 1 (REVIEWS3003)), (Bernhardt, R., 2004. Cytochrome P-450. Encyclopedia Biol. Chem. 1, 544–549), (Bernhardt, R., 2004. Optimized chimeragenesis; creating diverse P450 functions. Chem. Biol. 11, 287–288), (Guengerich, F.P., 2004. Cytochrome P450: what have we learned and what are the future issues? Drug Metab. Rev. 36, 159–197). More than 5000 different P450 genes have been cloned up to date (for details see: http://drnelson.utmem.edu/CytochromeP450.html ). Members of the same gene family are defined as usually having ≥40% sequence identity to a P450 protein from any other family. Mammalian sequences within the same subfamily are always >55% identical. The numbers of individual P450 enzymes in different species differ significantly, showing the highest numbers observed so far in plants. The structure–function relationships of cytochromes P450 are far from being well understood and their catalytic power has so far hardly been used for biotechnological processes. Nevertheless, the set of interesting reactions being catalysed by these systems and the availability of new genetic engineering techniques allowing to heterologously express them and to improve and change their activity, stability and selectivity as well as the increasing interest of the industry in life sciences makes them promising candidates for biotechnological application in the future." @default.
• W1964135958 created "2016-06-24" @default.
• W1964135958 creator A5011303922 @default.
• W1964135958 date "2006-06-01" @default.
• W1964135958 modified "2023-10-11" @default.
• W1964135958 title "Cytochromes P450 as versatile biocatalysts" @default.
• W1964135958 cites W1247495390 @default.
• W1964135958 cites W1486965577 @default.
• W1964135958 cites W1491133830 @default.
• W1964135958 cites W1498191276 @default.
• W1964135958 cites W1543749345 @default.
• W1964135958 cites W1547482025 @default.
• W1964135958 cites W1559964610 @default.
• W1964135958 cites W1574422260 @default.
• W1964135958 cites W1587582488 @default.
• W1964135958 cites W1650427240 @default.
• W1964135958 cites W1658284067 @default.
• W1964135958 cites W17658529 @default.
• W1964135958 cites W1807028851 @default.
• W1964135958 cites W1820410290 @default.
• W1964135958 cites W1864025888 @default.
• W1964135958 cites W1867574205 @default.
• W1964135958 cites W1951469402 @default.
• W1964135958 cites W1964891797 @default.
• W1964135958 cites W1965170368 @default.
• W1964135958 cites W1965951315 @default.
• W1964135958 cites W1972087447 @default.
• W1964135958 cites W1973433961 @default.
• W1964135958 cites W1974004653 @default.
• W1964135958 cites W1975262546 @default.
• W1964135958 cites W1976410590 @default.
• W1964135958 cites W1977677201 @default.
• W1964135958 cites W1979975835 @default.
• W1964135958 cites W1980170591 @default.
• W1964135958 cites W1980878239 @default.
• W1964135958 cites W1985280444 @default.
• W1964135958 cites W1986377015 @default.
• W1964135958 cites W1989272963 @default.
• W1964135958 cites W1989895996 @default.
• W1964135958 cites W1990206995 @default.
• W1964135958 cites W1990723450 @default.
• W1964135958 cites W1990974385 @default.
• W1964135958 cites W1993377119 @default.
• W1964135958 cites W1993911495 @default.
• W1964135958 cites W2000051743 @default.
• W1964135958 cites W2003305241 @default.
• W1964135958 cites W2004142891 @default.
• W1964135958 cites W2004291513 @default.
• W1964135958 cites W2006724140 @default.
• W1964135958 cites W2009774095 @default.
• W1964135958 cites W2010427858 @default.
• W1964135958 cites W2011565603 @default.
• W1964135958 cites W2011815597 @default.
• W1964135958 cites W2011826075 @default.
• W1964135958 cites W2012271559 @default.
• W1964135958 cites W2012555459 @default.
• W1964135958 cites W2012714287 @default.
• W1964135958 cites W2015290597 @default.
• W1964135958 cites W2018304920 @default.
• W1964135958 cites W2020936966 @default.
• W1964135958 cites W2022153068 @default.
• W1964135958 cites W2022289732 @default.
• W1964135958 cites W2024829623 @default.
• W1964135958 cites W2026894454 @default.
• W1964135958 cites W2027445993 @default.
• W1964135958 cites W2028238691 @default.
• W1964135958 cites W2030457289 @default.
• W1964135958 cites W2030859870 @default.
• W1964135958 cites W2032681818 @default.
• W1964135958 cites W2036732403 @default.
• W1964135958 cites W2036984750 @default.
• W1964135958 cites W2039804937 @default.
• W1964135958 cites W2039908717 @default.
• W1964135958 cites W2047544887 @default.
• W1964135958 cites W2047708413 @default.
• W1964135958 cites W2051536602 @default.
• W1964135958 cites W2051639214 @default.
• W1964135958 cites W2054637678 @default.
• W1964135958 cites W2055336628 @default.
• W1964135958 cites W2057620040 @default.
• W1964135958 cites W2063112093 @default.
• W1964135958 cites W2065063131 @default.
• W1964135958 cites W2069060069 @default.
• W1964135958 cites W2071086763 @default.
• W1964135958 cites W2071903638 @default.
• W1964135958 cites W2073458761 @default.
• W1964135958 cites W2073660800 @default.
• W1964135958 cites W2075467523 @default.
• W1964135958 cites W2077621515 @default.
• W1964135958 cites W2079761742 @default.
• W1964135958 cites W2079812065 @default.
• W1964135958 cites W2083112939 @default.
• W1964135958 cites W2085041652 @default.
• W1964135958 cites W2086424922 @default.
• W1964135958 cites W2087742245 @default.
• W1964135958 cites W2088061719 @default.
• W1964135958 cites W2091306392 @default.
• W1964135958 cites W2091660788 @default.

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