FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964144934> ?p ?o ?g. }

• W1964144934 endingPage "177" @default.
• W1964144934 startingPage "171" @default.
• W1964144934 abstract "The transmembrane collagenase MT1-MMP (membrane-type 1 matrix metalloproteinase), also known as MMP-14, has a critical function both in normal development and in cancer progression, and is subject to extensive controls at the post-translational level which affect proteinase activity. As zymogen activation is crucial for MT1-MMP activity, an alpha1-PI (alpha1-proteinase inhibitor)-based inhibitor was designed by incorporating the MT1-MMP propeptide cleavage sequence into the alpha1-PI reactive-site loop (designated alpha1-PI(MT1)) and this was compared with wild-type alpha1-PI (alpha1-PI(WT)) and the furin inhibitory mutant alpha1-PI(PDX). Alpha1-PI(MT1) formed an SDS-stable complex with furin and inhibited proMT1-MMP activation. A consequence of the loss of MT1-MMP activity was the activation of proMMP-2 and the inhibition of MT1-MMP-mediated collagen invasion. alpha1-PI(MT1) expression also resulted in the intracellular accumulation of a glycosylated species of proMT1-MMP that was retained in the perinuclear region, leading to significantly decreased cell-surface accumulation of proMT1-MMP. These observations suggest that both the subcellular localization and the activity of MT1-MMP are regulated in a coordinated fashion, such that proMT1-MMP is retained intracellularly until activation of its zymogen, then proMT1-MMP traffics to the cell surface in order to cleave extracellular substrates." @default.
• W1964144934 created "2016-06-24" @default.
• W1964144934 creator A5001372566 @default.
• W1964144934 creator A5034090671 @default.
• W1964144934 creator A5056768784 @default.
• W1964144934 creator A5063462261 @default.
• W1964144934 creator A5087149939 @default.
• W1964144934 creator A5087530743 @default.
• W1964144934 date "2007-09-25" @default.
• W1964144934 modified "2023-10-17" @default.
• W1964144934 title "Activation-coupled membrane-type 1 matrix metalloproteinase membrane trafficking" @default.
• W1964144934 cites W1534110607 @default.
• W1964144934 cites W1569326224 @default.
• W1964144934 cites W1578843331 @default.
• W1964144934 cites W1961749610 @default.
• W1964144934 cites W1974043792 @default.
• W1964144934 cites W1985504400 @default.
• W1964144934 cites W1990713423 @default.
• W1964144934 cites W1996347207 @default.
• W1964144934 cites W2006760268 @default.
• W1964144934 cites W2016484384 @default.
• W1964144934 cites W2023374250 @default.
• W1964144934 cites W2035143124 @default.
• W1964144934 cites W2035834978 @default.
• W1964144934 cites W2036877637 @default.
• W1964144934 cites W2051663130 @default.
• W1964144934 cites W2059196682 @default.
• W1964144934 cites W2059775810 @default.
• W1964144934 cites W2066071406 @default.
• W1964144934 cites W2073654276 @default.
• W1964144934 cites W2074187493 @default.
• W1964144934 cites W2088172329 @default.
• W1964144934 cites W2094842696 @default.
• W1964144934 cites W2107026123 @default.
• W1964144934 cites W2118523009 @default.
• W1964144934 cites W2125974759 @default.
• W1964144934 cites W2128049766 @default.
• W1964144934 cites W2132353833 @default.
• W1964144934 cites W2135081762 @default.
• W1964144934 cites W2146785334 @default.
• W1964144934 doi "https://doi.org/10.1042/bj20070552" @default.
• W1964144934 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2049019" @default.
• W1964144934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17650075" @default.
• W1964144934 hasPublicationYear "2007" @default.
• W1964144934 type Work @default.
• W1964144934 sameAs 1964144934 @default.
• W1964144934 citedByCount "13" @default.
• W1964144934 countsByYear W19641449342016 @default.
• W1964144934 countsByYear W19641449342022 @default.
• W1964144934 crossrefType "journal-article" @default.
• W1964144934 hasAuthorship W1964144934A5001372566 @default.
• W1964144934 hasAuthorship W1964144934A5034090671 @default.
• W1964144934 hasAuthorship W1964144934A5056768784 @default.
• W1964144934 hasAuthorship W1964144934A5063462261 @default.
• W1964144934 hasAuthorship W1964144934A5087149939 @default.
• W1964144934 hasAuthorship W1964144934A5087530743 @default.
• W1964144934 hasBestOaLocation W19641449342 @default.
• W1964144934 hasConcept C104317684 @default.
• W1964144934 hasConcept C109523444 @default.
• W1964144934 hasConcept C143065580 @default.
• W1964144934 hasConcept C1491633281 @default.
• W1964144934 hasConcept C153911025 @default.
• W1964144934 hasConcept C170493617 @default.
• W1964144934 hasConcept C181199279 @default.
• W1964144934 hasConcept C185592680 @default.
• W1964144934 hasConcept C189165786 @default.
• W1964144934 hasConcept C207583985 @default.
• W1964144934 hasConcept C24530287 @default.
• W1964144934 hasConcept C2777265534 @default.
• W1964144934 hasConcept C2778106830 @default.
• W1964144934 hasConcept C2778394429 @default.
• W1964144934 hasConcept C2778775115 @default.
• W1964144934 hasConcept C28406088 @default.
• W1964144934 hasConcept C55493867 @default.
• W1964144934 hasConcept C55728118 @default.
• W1964144934 hasConcept C79879829 @default.
• W1964144934 hasConcept C86803240 @default.
• W1964144934 hasConcept C95444343 @default.
• W1964144934 hasConceptScore W1964144934C104317684 @default.
• W1964144934 hasConceptScore W1964144934C109523444 @default.
• W1964144934 hasConceptScore W1964144934C143065580 @default.
• W1964144934 hasConceptScore W1964144934C1491633281 @default.
• W1964144934 hasConceptScore W1964144934C153911025 @default.
• W1964144934 hasConceptScore W1964144934C170493617 @default.
• W1964144934 hasConceptScore W1964144934C181199279 @default.
• W1964144934 hasConceptScore W1964144934C185592680 @default.
• W1964144934 hasConceptScore W1964144934C189165786 @default.
• W1964144934 hasConceptScore W1964144934C207583985 @default.
• W1964144934 hasConceptScore W1964144934C24530287 @default.
• W1964144934 hasConceptScore W1964144934C2777265534 @default.
• W1964144934 hasConceptScore W1964144934C2778106830 @default.
• W1964144934 hasConceptScore W1964144934C2778394429 @default.
• W1964144934 hasConceptScore W1964144934C2778775115 @default.
• W1964144934 hasConceptScore W1964144934C28406088 @default.
• W1964144934 hasConceptScore W1964144934C55493867 @default.
• W1964144934 hasConceptScore W1964144934C55728118 @default.
• W1964144934 hasConceptScore W1964144934C79879829 @default.
• W1964144934 hasConceptScore W1964144934C86803240 @default.

• next