Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964167839> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W1964167839 abstract "The glycoprotein quality control system exists in the endoplasmic reticulum to maintain protein homeostasis and prevent accumulation of aberrant glycoproteins. Folding sensor enzyme uridine diphosphate (UDP)glucose : glycoprotein glucosyltransferase (UGGT) plays an important role in this system through its ability to discriminate immature or misfolded glycoproteins from native ones. UGGT transfers a glucose residue to a glycoprotein containing Man9GlcNAc2 (M9; Man=mannose, GlcNAc=N-acetyl-D-glucosamine) N-glycan only when the glycoprotein has not attained a native form. We chemically prepared homogeneous glycoproteins containing M9 N-glycan in the native form as well as in misfolded forms and examined them as substrates of UGGT. Glucose transfer to misfolded glycoproteins was clearly observed by LC-MS, but glycoproteins in the native form were barely glucosylated. Furthermore, we constructed an in vitro glycoprotein folding system in the presence of UGGT and found out that all folding intermediates which appeared during folding were also glucosylated. Through these experiments, we demonstrated the usefulness of chemically synthesized homogeneous glycoproteins as probes to gain insights into the molecular basis of the glycoprotein quality control system." @default.
- W1964167839 created "2016-06-24" @default.
- W1964167839 creator A5026416439 @default.
- W1964167839 creator A5049594009 @default.
- W1964167839 creator A5078693517 @default.
- W1964167839 creator A5078891356 @default.
- W1964167839 date "2015-05-27" @default.
- W1964167839 modified "2023-09-27" @default.
- W1964167839 title "ChemInform Abstract: Chemical Synthesis of Homogeneous Glycoproteins for the Study of Glycoprotein Quality Control System" @default.
- W1964167839 cites W2951552939 @default.
- W1964167839 doi "https://doi.org/10.1002/chin.201524288" @default.
- W1964167839 hasPublicationYear "2015" @default.
- W1964167839 type Work @default.
- W1964167839 sameAs 1964167839 @default.
- W1964167839 citedByCount "0" @default.
- W1964167839 crossrefType "journal-article" @default.
- W1964167839 hasAuthorship W1964167839A5026416439 @default.
- W1964167839 hasAuthorship W1964167839A5049594009 @default.
- W1964167839 hasAuthorship W1964167839A5078693517 @default.
- W1964167839 hasAuthorship W1964167839A5078891356 @default.
- W1964167839 hasConcept C108625454 @default.
- W1964167839 hasConcept C119599485 @default.
- W1964167839 hasConcept C127413603 @default.
- W1964167839 hasConcept C158617107 @default.
- W1964167839 hasConcept C185592680 @default.
- W1964167839 hasConcept C206212055 @default.
- W1964167839 hasConcept C2775887612 @default.
- W1964167839 hasConcept C2776545253 @default.
- W1964167839 hasConcept C55493867 @default.
- W1964167839 hasConceptScore W1964167839C108625454 @default.
- W1964167839 hasConceptScore W1964167839C119599485 @default.
- W1964167839 hasConceptScore W1964167839C127413603 @default.
- W1964167839 hasConceptScore W1964167839C158617107 @default.
- W1964167839 hasConceptScore W1964167839C185592680 @default.
- W1964167839 hasConceptScore W1964167839C206212055 @default.
- W1964167839 hasConceptScore W1964167839C2775887612 @default.
- W1964167839 hasConceptScore W1964167839C2776545253 @default.
- W1964167839 hasConceptScore W1964167839C55493867 @default.
- W1964167839 hasLocation W19641678391 @default.
- W1964167839 hasOpenAccess W1964167839 @default.
- W1964167839 hasPrimaryLocation W19641678391 @default.
- W1964167839 hasRelatedWork W2000319181 @default.
- W1964167839 hasRelatedWork W2036934049 @default.
- W1964167839 hasRelatedWork W2045722793 @default.
- W1964167839 hasRelatedWork W2070750261 @default.
- W1964167839 hasRelatedWork W2072838264 @default.
- W1964167839 hasRelatedWork W2088293716 @default.
- W1964167839 hasRelatedWork W2106413711 @default.
- W1964167839 hasRelatedWork W2108496927 @default.
- W1964167839 hasRelatedWork W2128788229 @default.
- W1964167839 hasRelatedWork W2205218393 @default.
- W1964167839 hasRelatedWork W2274876903 @default.
- W1964167839 hasRelatedWork W2442589661 @default.
- W1964167839 hasRelatedWork W2462075350 @default.
- W1964167839 hasRelatedWork W2510142257 @default.
- W1964167839 hasRelatedWork W2570389843 @default.
- W1964167839 hasRelatedWork W277055403 @default.
- W1964167839 hasRelatedWork W2808934065 @default.
- W1964167839 hasRelatedWork W2903281315 @default.
- W1964167839 hasRelatedWork W2951552939 @default.
- W1964167839 hasRelatedWork W3094131322 @default.
- W1964167839 isParatext "false" @default.
- W1964167839 isRetracted "false" @default.
- W1964167839 magId "1964167839" @default.
- W1964167839 workType "article" @default.