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- W1964173876 abstract "Abstract The function of each kidney was assessed separately in a patient with predominantly unilateral renal involvement by Hodgkin's disease. Initially, the greatly enlarged diseased kidney exhibited diminished concentrating ability, and its glomerular filtration rate was only 6 per cent of the contralateral value. After a three month course of cytotoxic chemotherapy, utilizing a combination of four drugs, the size of the affected kidney decreased substantially. Although the glomerular filtration rates on both sides remained unchanged, concentrating ability improved markedly on the diseased side. In addition, the relative rates of uric acid and potassium excretion normalized, as compared to the contralateral kidney. These data imply that the renal concentrating mechanism in disease may be affected by intrarenal parameters extrinsic to the remaining functioning nephrons, possibly by such potentially reversible factors as cellular infiltrate, edema and elevated renal interstitial pressure." @default.
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- W1964173876 title "A reversible concentrating defect in predominantly unilateral renal Hodgkin's disease" @default.
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- W1964173876 doi "https://doi.org/10.1016/0002-9343(70)90068-9" @default.
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