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• W1964185514 endingPage "6405" @default.
• W1964185514 startingPage "6401" @default.
• W1964185514 abstract "Murine cytotoxic T lymphocytes (CTL) and helper cells are H-2 antigen restricted in their specificity: recognition of foreign antigen by these cells requires the concomitant recognition of self-H-2 molecules. Which H-2 antigens T cells treat as self is determined by the particular H-2 antigens expressed on radioresistant cells of the thymus in which these T cells mature. Using tetraparental [(P1 + P2) leads to F1] radiation chimeras with in situ F1 thymuses, we have found that the H-2 genotype of the stem cells does not influence their H-2 restriction specificity. This has allowed us to use tetraparental chimeras that have been thymectomized and grafted with parental (P1, P2, or both) thymus lobes to study the requirements for H-2-restricted T--T interactions during CTL ontogeny and induction. In animals that have received thymus grafts of both parental origins, CTL display no preference for maturation within a syngeneic thymus graft, a finding that is not compatible with a suggested requirement for intrathymic H-2-restricted T--T interactions in the maturation of precursor CTL. We have also grafted thymectomized tetraparental radiation chimeras with thymus grafts from only one parent to compare the induction of P1 and P2 CTL in environments in which peripheral (extrathymic) T cell interactions are restricted to one H-2 haplotype. Again, we find no evidence for preferential induction of CTL precursors syngeneic to the thymus graft, contrary to expectation if CTL induction requires that T helper cells restricted to thymic H-2 antigens interact directly with precursor CTL. In those animals with one parental thymus graft, there is variability in the ratios of P1 and P2 cells induced with several antigens, a finding that may be indicative of an H-2-restricted suppression mechanism operating in the periphery." @default.
• W1964185514 created "2016-06-24" @default.
• W1964185514 creator A5036928658 @default.
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• W1964185514 date "1981-10-01" @default.
• W1964185514 modified "2023-09-25" @default.
• W1964185514 title "Influence of H-2 antigen expression on killer T cell specificity, differentiation, and induction." @default.
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• W1964185514 doi "https://doi.org/10.1073/pnas.78.10.6401" @default.
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