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- W1964190904 abstract "A promising avenue in cancer therapy using liposomal formulations is the combination of site-specific delivery with triggered drug release. The use of trigger mechanisms in liposomes could be relevant for drugs susceptible to lysosomal hydrolytic/enzymatic degradation. Here, we propose a polymeric pH-sensitive liposome system that is designed to release its content inside the endosomes through a polymer structural change following receptor-mediated internalization. Specifically, pH-sensitive immunoliposomes (ILs) were obtained by including a terminally alkylated copolymer of N-isopropylacrylamide (NIPAM) in the liposome bilayer and by coupling the anti-CD33 monoclonal antibody to target leukemic cells. In vitro release of encapsulated fluorescent probes and cytosine arabinoside (ara-C) revealed that pH-sensitivity of the vector was retained in the presence of the antibody upon incubation in plasma. Flow cytometry and confocal microscopy analyses demonstrated that the pH-sensitive ILs were efficiently internalized by various CD33+ leukemic cell lines while limited interaction was found for liposomes decorated with an isotype-matched control antibody. Finally, the pH-sensitive ILs-CD33 formulation exhibited the highest cytotoxicity against HL60 cells, confirming the role of the NIPAM copolymer in promoting the escape of intact ara-C in the endosomes. These results suggest that this pH-sensitive liposomal formulation could be beneficial in the treatment of acute myeloid leukemia." @default.
- W1964190904 created "2016-06-24" @default.
- W1964190904 creator A5037568170 @default.
- W1964190904 creator A5065805582 @default.
- W1964190904 date "2009-11-01" @default.
- W1964190904 modified "2023-10-13" @default.
- W1964190904 title "pH-sensitive immunoliposomes specific to the CD33 cell surface antigen of leukemic cells" @default.
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- W1964190904 doi "https://doi.org/10.1016/j.ijpharm.2009.05.013" @default.
- W1964190904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19446624" @default.
- W1964190904 hasPublicationYear "2009" @default.
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