Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964194803> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W1964194803 endingPage "462" @default.
- W1964194803 startingPage "459" @default.
- W1964194803 abstract "Cytochrome P450 2B6 (CYP2B6) is a potentially important enzyme for the metabolism of clinical drugs, and it exhibits genetic polymorphism. Thus far, 29 allelic variants of CYP2B6 (CYP2B6*1-CYP2B6*29) have been identified. This study aimed to investigate whether 26 of the variant alleles of CYP2B6 (CYP2B6*2-CYP2B6*21 and CYP2B6*23-CYP2B6*28) affect its kinetics in the metabolism of 7-ethoxy-4-trifluoromethylcoumarin (7-EFC) and selegiline. Wild-type CYP2B6.1 and the allelic variants were heterologously expressed in COS-7 cells. In-vitro kinetic analysis revealed that when compared with the wild-type protein CYP2B6.1, CYP2B6.10 and CYP2B6.14 exhibited significantly lower V(max)/K(m) values for selegiline N-demethylation. The kinetic parameters of CYP2B6.8, CYP2B6.11, CYP2B6.12, CYP2B6.13, CYP2B6.15, CYP2B6.18, CYP2B6.21, CYP2B6.24, and CYP2B6.28 could not be determined because these enzymes were inactive in the deethylation of 7-EFC and the N-demethylation/N-depropagylation of selegiline. These findings provide useful information for further genotype-phenotype studies on interindividual differences in the metabolism of CYP2B6 substrate drugs." @default.
- W1964194803 created "2016-06-24" @default.
- W1964194803 creator A5012209368 @default.
- W1964194803 creator A5013490553 @default.
- W1964194803 creator A5023757160 @default.
- W1964194803 creator A5055976986 @default.
- W1964194803 creator A5080010429 @default.
- W1964194803 creator A5090833783 @default.
- W1964194803 creator A5090905175 @default.
- W1964194803 date "2010-07-01" @default.
- W1964194803 modified "2023-09-30" @default.
- W1964194803 title "Functional characterization of 26 CYP2B6 allelic variants (CYP2B6.2–CYP2B6.28, except CYP2B6.22)" @default.
- W1964194803 cites W1967951091 @default.
- W1964194803 cites W199559419 @default.
- W1964194803 cites W2004689547 @default.
- W1964194803 cites W2037769618 @default.
- W1964194803 cites W2044894026 @default.
- W1964194803 cites W2072232675 @default.
- W1964194803 cites W2109808952 @default.
- W1964194803 cites W2128182429 @default.
- W1964194803 cites W2169136493 @default.
- W1964194803 cites W2755604 @default.
- W1964194803 doi "https://doi.org/10.1097/fpc.0b013e32833bba0e" @default.
- W1964194803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20517174" @default.
- W1964194803 hasPublicationYear "2010" @default.
- W1964194803 type Work @default.
- W1964194803 sameAs 1964194803 @default.
- W1964194803 citedByCount "36" @default.
- W1964194803 countsByYear W19641948032012 @default.
- W1964194803 countsByYear W19641948032013 @default.
- W1964194803 countsByYear W19641948032014 @default.
- W1964194803 countsByYear W19641948032015 @default.
- W1964194803 countsByYear W19641948032016 @default.
- W1964194803 countsByYear W19641948032017 @default.
- W1964194803 countsByYear W19641948032018 @default.
- W1964194803 countsByYear W19641948032019 @default.
- W1964194803 countsByYear W19641948032020 @default.
- W1964194803 countsByYear W19641948032021 @default.
- W1964194803 countsByYear W19641948032022 @default.
- W1964194803 crossrefType "journal-article" @default.
- W1964194803 hasAuthorship W1964194803A5012209368 @default.
- W1964194803 hasAuthorship W1964194803A5013490553 @default.
- W1964194803 hasAuthorship W1964194803A5023757160 @default.
- W1964194803 hasAuthorship W1964194803A5055976986 @default.
- W1964194803 hasAuthorship W1964194803A5080010429 @default.
- W1964194803 hasAuthorship W1964194803A5090833783 @default.
- W1964194803 hasAuthorship W1964194803A5090905175 @default.
- W1964194803 hasConcept C109650736 @default.
- W1964194803 hasConcept C185592680 @default.
- W1964194803 hasConcept C50605568 @default.
- W1964194803 hasConcept C526171541 @default.
- W1964194803 hasConcept C55493867 @default.
- W1964194803 hasConcept C62231903 @default.
- W1964194803 hasConcept C86803240 @default.
- W1964194803 hasConcept C98274493 @default.
- W1964194803 hasConceptScore W1964194803C109650736 @default.
- W1964194803 hasConceptScore W1964194803C185592680 @default.
- W1964194803 hasConceptScore W1964194803C50605568 @default.
- W1964194803 hasConceptScore W1964194803C526171541 @default.
- W1964194803 hasConceptScore W1964194803C55493867 @default.
- W1964194803 hasConceptScore W1964194803C62231903 @default.
- W1964194803 hasConceptScore W1964194803C86803240 @default.
- W1964194803 hasConceptScore W1964194803C98274493 @default.
- W1964194803 hasIssue "7" @default.
- W1964194803 hasLocation W19641948031 @default.
- W1964194803 hasLocation W19641948032 @default.
- W1964194803 hasOpenAccess W1964194803 @default.
- W1964194803 hasPrimaryLocation W19641948031 @default.
- W1964194803 hasRelatedWork W1977246230 @default.
- W1964194803 hasRelatedWork W2022934573 @default.
- W1964194803 hasRelatedWork W2055881556 @default.
- W1964194803 hasRelatedWork W2108765637 @default.
- W1964194803 hasRelatedWork W2515948156 @default.
- W1964194803 hasRelatedWork W2739123624 @default.
- W1964194803 hasRelatedWork W2803235181 @default.
- W1964194803 hasRelatedWork W2889903634 @default.
- W1964194803 hasRelatedWork W3133873564 @default.
- W1964194803 hasRelatedWork W4284669428 @default.
- W1964194803 hasVolume "20" @default.
- W1964194803 isParatext "false" @default.
- W1964194803 isRetracted "false" @default.
- W1964194803 magId "1964194803" @default.
- W1964194803 workType "article" @default.