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• W1964212933 abstract "lthough myelosuppression is considered to be the major dose-limiting toxic effect of :ytostatic chemotherapy, when patients are asked which adverse event affects them most lausea and vomiting is generally the most common reply (6). Chemotherapy most often nduces nausea and vomiting within 1 2 h of treatment and the acute emesis usually lasts or 24 h (15). Most studies of anti-emetic treatments have examined emesis control in this )eriod. The best treatment available betbre the advent of the 5-HT3 receptor antagonists, ligh-dose metoclopramide, is only partially effective in patients receiving highly emeto,~enic chemotherapy such as high-dose cisplatin even when used in combination with )ther agents. Complete anti-emetic control in the acute period is important. The main :onsequence of poor initial control is that 1-57°,, o of patients will suffer from anticipatory lausea, depending on the emetogenicity of their chemotherapy regimen, which may lead o refusal of further potentially curative courses of chemotherapy (3, 26, 27). The medical complications of persistent vomiting include: dehydration, electrolyte mbalance, metabolic alkalosis, decreased renal elimination of drugs, malnutrition, vitamin teficiencies, oesophageal tears, aspiration pneumonia and pathological fractures (21). In tddition, patients receiving monthly cycles of chemotherapy may experience delayed ~ausea and vomiting tbr up to 3 weeks out of every 4, and the effects of this on their tuality oflit~ include anxiety, depression, restriction of social life, job loss and even suicide 21, 34). Thus, there is clearly a need for anti-emetics which a~e not only effective tgainst vomiting, but also proved to be effective against nausea because the mechanisms mderlying the development of nausea may be substantially different from those involved n vomiting. The identification of such treatments will require a standardized, simple, ~ccurate and reproducible method tbr assessing the patient's experience of nausea and the mpact of anti-emetic treatment on it." @default.
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• W1964212933 creator A5062762491 @default.
• W1964212933 date "1991-06-01" @default.
• W1964212933 modified "2023-09-27" @default.
• W1964212933 title "How should nausea be assessed in patients receiving chemotherapy?" @default.
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• W1964212933 doi "https://doi.org/10.1016/0305-7372(91)90008-n" @default.
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